| 1. |
- Rask, Olof, et al.
(författare)
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Oestrogen treatment of constitutional tall stature in girls: is there a risk of thrombosis or bleeding?
- 2008
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Ingår i: Acta Pædiatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 97:3, s. 342-347
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To evaluate haemostatic effects and clinical outcome of oestrogen treatment of constitutionally tall stature in girls. Methods: We conducted a single-centre cohort study, 63 girls referred over a period of 15 years were investigated. The girls were given oestrogen treatment for constitutional tall stature at a median initial dose of 300 ug ethinyl estradiol/day and were consecutively examined for changes in coagulation. Medical records were retrospectively reviewed, additional data were collected at follow-up by blood sampling and interviews. Results: After 1 year of treatment, levels of antithrombin and von Willebrand factor (VWF) were significantly decreased (p < 0.001 and p = 0.015, respectively), whereas there was no significant change in levels of plasminogen inhibitor type 1. No venous thromboembolism (VTE) or major side effects were observed. Genetic risk factors for thrombosis were present, as was expected. The mean height reduction was 5.5 cm. The height-reducing effect was inversely correlated with chronological age (r =-0.44, p < 0.01) and bone age (r =-0.61, p < 0.01). Conclusions: Changes in coagulation parameters occurred both towards pro- and anticoagulation. Treatment with high-dose ethinyl estradiol can successfully limit final height, and it is most effective when started at a younger bone age.
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| 2. |
- Gustafsson, Åsa, et al.
(författare)
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Erfarenheter av logistik- och montageprocessen vid byggandet av höga flerbostadshus med trästomme : Del 2 : Faktorer som påverkat tidseffektiviteten vid projekt Limologen, Växjö 2007
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Föreliggande rapport är den andra av tre avrapporteringar kring erfarenheter av att bygga höga flerbostadshus med trästomme. Forskningsprojektet har sin empiriska bas i Midroc´s bygge av fyra åttavåningars hus för bostadsrätter vid Trummens strand i Växjö.Data samlades in under 2007 och analys och diskussion är gjord på detta material. De problem och förbättringsbehov som identifierats hänför sig alltså till det system som användes under 2007 och som i huvudsak kommer att användas för de efterföljande byggnaderna i kvarteret Limnologen. Erfarenheterna som gjorts under byggtiden har lett till att leverantören för kommande byggprojekt vidareutvecklat byggsystemet främst avseende en högre prefabriceringsnivå och ett effektivare och flexiblare system för väderskydd och traverslyft.Projektet är en del av insatser från Nationella Träbyggstrategin och Centrum för Byggande och Boende med Trä (CBBT) för att öka kunskapen om modernt stort träbyggande.Projektet har finansierats av Nationella Träbyggstrategin, CBBT, Växjö universitet och SP Trätek.
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| 3. |
- Helstad, Klara, 1977-
(författare)
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Managing timber procurement in Nordic purchasing sawmills
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Procurement of sawlogs to purchasing sawmills represents a basic strategic business process. The properties of inbound sawlogs are decisive for the output of sawn products and the cost of raw material contributes substantially to the cost of the final product. Increasing customer orientation and new demands from powerful customers in the building and retail sectors entail new or accentuated demands on management of procurement. Managing raw material procurement and communicating needs to suppliers and logging machine operators are vital issues for sawmills in order to be competitive.The purpose of the thesis is to explore how purchasing sawmills manage procurement of sawlogs. The results are based on 46 in-depth interviews with people involved in the procurement process at seven softwood sawmills in Denmark, Finland and Sweden. The thesis identifies various types of supply uncertainties as well as process improvement and buffer activities that reduce uncertainties. However, the major obstacle in the procurement process is the power/dependence balance in the relationships with suppliers. Beyond doubt, it restricts the manageability of procurement and particularly bucking. The results suggest that there are a number of ways to improve management of procurement, which are currently not fully employed. The thesis provides four key strategic dimensions of the procurement process and suggests a general conceptual model of wood procurement to purchasing sawmills.Further research within the subject can usefully explore the link between procurement management and procurement strategy as well as the relation to other functions' strategies and the corporate strategy. The importance of the identified strategic dimensions of the procurement process needs to be quantified in order to provide normative suggestions.
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| 4. |
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| 5. |
- Martin, Nathalie, 1972-
(författare)
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Studies on the regulation of the Napin napA promoter by ABI3, bZIP and bHLH transcription factors
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The B3-domain transcription factor ABI3 is a major regulator of gene expression of seed maturation during Arabidopsis embryogenesis. The napA gene encodes for a Brassica napus 2S storage protein specifically expressed in the embryo during the early and mid-maturation phase (MAT program).The napA promoter contains two essential cis-sequences; the B-box, which functions as an Abscisic acid-responsive element (ABRE) and the RY/G cluster. ABI3 is known to target both these cis-sequences. Several bZIP factors expressed during seed maturation, bZIP12, bZIP38 and bZIP66, as well as a heterodimer of ABI5 and bZIP67, can bind the B-box ABRE in a yeast one-hybrid assay. Amongst them ABI3 and bZIP67 are able to activate synergistically the two cis-elements in a transient protoplast assay. We also show that bZIP67 interacts directly with ABI3 in a yeast two-hybrid assay. Therefore, we hypothesize that i)ABI3 is recruited indirectly to napA through molecular interaction with bZIP67 bound to the B-box ABRE, ii) ABI3 binds directly to the RY-element and interacts with bZIP67 targeted to the adjacent G-box found in the napA RY/G-cluster.We also show that the RY/G cluster is responsible for repression of napA expression during the late maturation LEA program, and for repression of ABI3-mediated transactivation during germination. ABI3 from which the A1 activation domain had been removed, can bind to the napA RY-element in a yeast one-hybrid assay, in contrast to full-length ABI3, suggesting that ABI3 DNA-binding abilities are regulated by auto-inhibition. We propose that during late maturation ABI3 loses ability to bind RY, which results in repression of MAT genes but not of LEA genes that contain fewer RY-elements. In parallel, we show that the B3-domain VAL proteins bind to RY-elements and decrease ABI3-mediated transactivation of the napA RY/G and therefore act as active repressors maintaining silencing of MAT genes during vegetative growth.
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| 6. |
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| 7. |
- Rask, Olof, et al.
(författare)
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Lower incidence of procoagulant abnormalities during follow-up after creation of the Fontan circulation in children.
- 2009
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Ingår i: Cardiology in the Young. - 1467-1107. ; 19, s. 152-158
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe studied, prior to surgery, the coagulation profiles of a cohort of 28 children admitted for a modified Fontan operation, studying them again after a period of mean follow-up of 9.6 years. Median age at the time of final surgery was 18.5 months, with a range from 12 to 76 months. We compared generation of thrombin, and levels of the activated protein C-protein C inhibitor complex to controls at follow-up. Thrombophilia and clinical outcome were evaluated. RESULTS: At long-term follow-up, a lower incidence of procoagulant abnormalities was observed compared to that before surgery. Of 27 patients, 3 (11%), but none of 45 controls, had levels of activated protein C-protein C inhibitor complex above the reference range. There were no significant differences in generation of thrombin between patients and controls. No thrombotic events were recorded, and the patients were generally in good clinical condition. CONCLUSIONS: Overall, haemostasis appeared to be in balance, and less prothrombotic, after surgery. A subset of the cohort did show indications of activated coagulation. The current therapeutic approach seems to be sufficient to protect the majority of patient. New tests of global coagulation, nonetheless, may be helpful in improving identification of individuals at increased thrombotic risk.
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| 8. |
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| 9. |
- Rask, Olof
(författare)
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Thrombosis in Children
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aims: The general objective was to further elucidate thromboembolic disease in children and thereby help improve the care of these patients. More specific aims were as follows: to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins constitute a risk factor for childhood thrombosis; to study girls receiving estrogen treatment with regard to induced hemostatic changes and efficacy of the therapy; to investigate long-term effects on the hemostatic system in children subjected to heart surgery. Material and methods: Children with thrombosis (Papers I and II) and children at risk of thrombosis (Papers III and IV) were investigated. In the initial study, 128 children referred for a first thrombotic event were retrospectively evaluated. In a subsequent endeavor, 57 children with thrombosis were prospectively included and evaluated for thrombotic risk factors, and patients and controls were investigated for autoantibodies. Considering children at risk, 63 girls treated with high doses of ethinyl estradiol were studied. Furthermore, 28 children with congenital heart defects were evaluated before and after Fontan surgery, and the results of follow-up global coagulation tests in patients and controls were analyzed. Results and conclusions: The present studies showed a bimodal age distribution in pediatric thrombosis patients in Sweden, with peaks in frequency rates during the neonatal period and in adolescence. The girls:boys ratio was 2:1. Of the children with thrombosis, 84% had acquired risk factors and they showed a significantly increased prevalence of inherited thrombophilia. Also, autoantibodies against prothrombin were significantly more often detected than in controls, suggesting immunological pathogenesis. Pediatric thrombosis often seem to be elicited by a combination of risk factors. Girls receiving high-dose estrogen treatment exhibited both pro- and anticoagulation abnormalities; the estrogen therapy was most effective when started at a younger bone age, and the risk of thrombosis was <5% and considered a safe treatment in our cohort. Post-Fontan patients had a lower incidence of procoagulant abnormalities at long-term follow-up compared to before surgery, although a subset of the subjects showed evidence of elevated thrombin generation, identified by increases in APC-PCI, as compared to controls. The results indicate that prophylaxis to prevent thrombosis in these children should be individualized.
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| 10. |
- Stehn, Lars, et al.
(författare)
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Byggandet av flervåningshus i trä : erfarenhet efter tre års observation av träbyggandets utveckling
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I utredningen ”Mer trä i byggandet”, Ds 2004:01, som ledde fram till Nationella träbyggnadsstrategin slogs fast att: för att öka träbyggandet krävs utbildningsinsatser både av studenter och via fortbildning av yrkesverksamma ute i arbetslivet. Denna rapport är en sammanfattning av kunskaperna vunna ur de aktiviteter som genomfördes inom Nationella träbyggnadsstrategins fortbildningsprogram mellan 2006-2008. Kunskaper och resultat har även vävts in från flera FoU program riktat att stötta träbyggandet som utfördes parallellt med Nationella träbyggnadsstrategin. Fortbildningsprogrammet var ett samverkansprojekt mellanLuleå tekniska universitet, Växjö universitet, Högskolan Dalarna och SP Trätek I rapporten beskrivs: Teknik och kompetensutveckling inom träbyggandet, Systembeskrivningar av träbyggprojekt med fokus på objekt uppförda i Växjö, Falun och Skellefteå. Vidare ges vetenskapliga systembeskrivningar av industriellt träbyggande med definitioner byggsystem (tekniken), av aktörsroller, affärsmodeller och vad egentligen industriellt byggande handlar om (processen för industriellt byggande). Rapporten avslutas med en vägledning till byggandets aktörer: kommuner, arkitekter, leverantörer/entreprenörer.
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