The effect of ciprofloxacin injection on genetically absence prone (Wag/Rij) Rat's electroencephalogram characteristics

• Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

article

risk assessment

nonhuman

Absence epilepsy

animal model

4 aminobutyric acid metabolism

animal experiment

Wag/rij

rat

electroencephalography

male

electrode implant

magnesium

seizure susceptibility

controlled study

brain cortex

experimental rat

ECG abnormality

animal tissue

absence

Ciprofloxacin

neuropathology

pathophysiology

EEG

causal attribution

GABAergic system

neurotoxicity

spike wave

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)