| 1. |
- Arlat, Jean, et al.
(författare)
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Fourth workshop on dependable and secure nanocomputing
- 2010
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Ingår i: Proceedings of the International Conference on Dependable Systems and Networks; 2010 IEEE/IFIP International Conference on Dependable Systems and Networks, DSN 2010; Chicago, IL; 28 June 2010 through 1 July 2010. - 9781424475018 ; , s. 619-620
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Konferensbidrag (refereegranskat)abstract
- Nanocomputing technologies hold the promise for higher performance, lower power consumption as well as increased functionality. However, the dependability of these unprecedentedly small scale devices remains uncertain. The main sources of concern are: • Nanometer devices are expected to be highly sensitive to process variations. The guard-bands used today for avoiding the impact of such variations will not represent a feasible solution in the future. Thus, timing errors may occur more frequently. • New failure modes, specific to new materials, are expected to raise serious challenges to the design and test engineers. • Environment induced errors, like single event upsets (SED), are likely to occur more frequently than in the case of conventional semiconductor devices. • New hardware redundancy techniques are needed to enable development of energy efficient systems. • The increased complexity of the systems based on nanotechnology will require improved computer aided design (CAD) tools, as well as better validation techniques. • Security of nanocomputing systems may be threatened by malicious attacks targeting new vulnerable areas in the hardware. © 2010 IEEE.
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| 2. |
- Arlat, Jean, et al.
(författare)
-
Fourth workshop on dependable and secure nanocomputing
- 2010
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Ingår i: Proceedings of the International Conference on Dependable Systems and Networks; 2010 International Conference on Dependable Systems and Networks Workshops, DSN-W 2010; Chicago, IL; 28 June 2010 through 1 July 2010. - 9781424477302 ; , s. 93-94
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Konferensbidrag (refereegranskat)
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| 3. |
- Cherkaoui, Abdelkarim, et al.
(författare)
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New paradigms for access control in constrained environments
- 2014
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Ingår i: 2014 9th International Symposium on Reconfigurable and Communication-Centric Systems-on-Chip, ReCoSoC 2014. - : IEEE Computer Society. - 9781479958108
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Konferensbidrag (refereegranskat)abstract
- The Internet of Things (IoT) is here, more than 10 billion units are already connected and five times more devices are expected to be deployed in the next five years. Technological standarization and the management and fostering of rapid innovation by governments are among the main challenges of the IoT. However, security and privacy are the key to make the IoT reliable and trusted. Security mechanisms for the IoT should provide features such as scalability, interoperability and lightness. This paper addresses authentication and access control in the frame of the IoT. It presents Physical Unclonable Functions (PUF), which can provide cheap, secure, tamper-proof secret keys to authentify constrained M2M devices. To be successfully used in the IoT context, this technology needs to be embedded in a standardized identity and access management framework. On the other hand, Embedded Subscriber Identity Module (eSIM) can provide cellular connectivity with scalability, interoperability and standard compliant security protocols. The paper discusses an authorization scheme for a constrained resource server taking advantage of PUF and eSIM features. Concrete IoT uses cases are discussed (SCADA and building automation).
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| 4. |
- Reddy, B. K. Kishore, et al.
(författare)
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Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors
- 2014
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Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 58:6, s. 3312-3326
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Tidskriftsartikel (refereegranskat)abstract
- Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate kinase in Mycobacterium tuberculosis, and this vital information was then exploited to screen large libraries for identification of mechanistically different classes of PanK inhibitors. The present report summarizes the synthesis and expansion efforts to understand the structure-activity relationships leading to the optimization of enzyme inhibition along with antimycobacterial activity. Additionally, we report the progression of two distinct classes of inhibitors, the triazoles, which are ATP competitors, and the biaryl acetic acids, with a mixed mode of inhibition. Cocrystallization studies provided evidence of these inhibitors binding to the enzyme. This was further substantiated with the biaryl acids having MIC against the wild-type M. tuberculosis strain and the subsequent establishment of a target link with an upshift in MIC in a strain overexpressing PanK. On the other hand, the ATP competitors had cellular activity only in a M. tuberculosis knockdown strain with reduced PanK expression levels. Additionally, in vitro and in vivo survival kinetic studies performed with a M. tuberculosis PanK (MtPanK) knockdown strain indicated that the target levels have to be significantly reduced to bring in growth inhibition. The dual approaches employed here thus established the poor vulnerability of PanK in M. tuberculosis.
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| 5. |
- Shum, Anthony K., et al.
(författare)
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BPIFB1 Is a Lung-Specific Autoantigen Associated with Interstitial Lung Disease
- 2013
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 5:206, s. 206ra139-
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Tidskriftsartikel (refereegranskat)abstract
- Interstitial lung disease (ILD) is a complex and heterogeneous disorder that is often associated with autoimmune syndromes. Despite the connection between ILD and autoimmunity, it remains unclear whether ILD can develop from an autoimmune response that specifically targets the lung parenchyma. We examined a severe form of autoimmune disease, autoimmune polyglandular syndrome type 1 (APS1), and established a strong link between an autoimmune response to the lung-specific protein BPIFB1 (bactericidal/permeability-increasing fold-containing B1) and clinical ILD. Screening of a large cohort of APS1 patients revealed autoantibodies to BPIFB1 in 9.6% of APS1 subjects overall and in 100% of APS1 subjects with ILD. Further investigation of ILD outside the APS1 disorder revealed BPIFB1 autoantibodies present in 14.6% of patients with connective tissue disease-associated ILD and in 12.0% of patients with idiopathic ILD. The animal model for APS1, Aire(-/-) mice, harbors autoantibodies to a similar lung antigen (BPIFB9); these autoantibodies are a marker for ILD. We found that a defect in thymic tolerance was responsible for the production of BPIFB9 autoantibodies and the development of ILD. We also found that immunoreactivity targeting BPIFB1 independent of a defect in Aire also led to ILD, consistent with our discovery of BPIFB1 autoantibodies in non-APS1 patients. Overall, our results demonstrate that autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of ILD in patients with APS1 and in subsets of patients with non-APS1 ILD, demonstrating the role of lung-specific autoimmunity in the genesis of ILD.
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