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Sökning: WFRF:(Reda G) > (2021)

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  • Chatzikonstantinou, T, et al. (författare)
  • COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
  • 2021
  • Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:12, s. 3444-3454
  • Tidskriftsartikel (refereegranskat)abstract
    • Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
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  • Alouhmy, M., et al. (författare)
  • Effects of hydrogen implantation on the magnetocaloric properties of amorphous FeZr films
  • 2021
  • Ingår i: Vacuum. - : Elsevier. - 0042-207X .- 1879-2715. ; 186
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the effects of H-implantation on the magnetic and magnetocaloric properties of amorphous FeZr films. Arrott plots reveal a second order ferromagnetic to paramagnetic phase transition for the as-grown and H-implanted films, with an increase in T-C from 160 to 200 K upon implantation. The maximum change in magnetic entropy (-Delta S-M) increases from 0.66 to 0.77J/kgK for a field change mu 0 Delta H = 1.5T, as well as the relative cooling power (RCP) values were improved from 84.5 to 108.6J/kg. This improvement was attributed to the increase in magnetization and chemical inhomogeneity induced by the implantation process. The increase in the chemical inhomogeneity was supported by the determination of the local exponent n extracted from the slope of Ln(-Delta S-M) as a function of Ln(mu 0H), which is line with the simulated depth profile of hydrogen atoms through the FeZr film.
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