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Multimodal approach...
Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts.
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Arteaga-Marrero, N (författare)
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Rygh, C B (författare)
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Mainou-Gomez, J F (författare)
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Nylund, K (författare)
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Roehrich, D (författare)
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Heggdal, J (författare)
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Matulaniec, P (författare)
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Gilja, O H (författare)
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Reed, R K (författare)
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- Svensson, Lena M (författare)
- Lund University,Lunds universitet,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups
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- Lutay, Nataliya (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Olsen, D R (författare)
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(creator_code:org_t)
- 2015-05-26
- 2015
- Engelska.
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Ingår i: Contrast Media & Molecular Imaging. - : Wiley. - 1555-4317 .- 1555-4309. ; 10:6, s. 428-437
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo DCE-US and DCE-MRI were obtained 24 h pre- (day 0) and post- (day 2) radiation treatment with a single dose of 7.5 Gy. Characterization of the tumour vasculature was determined by Brix pharmacokinetic analysis of the time-intensity curves. Histogram analysis of voxels showed significant changes (p < 0.001) from day 0 to day 2 in both modalities for kep , the exchange rate constant from the extracellular extravascular space to the plasma, and kel , the elimination rate constant of the contrast. In addition, kep and kel values from DCE-US were significantly higher than those derived from DCE-MRI at day 0 (p < 0.0001) for both groups. At day 2, kel followed the same tendency for both groups, whereas kep showed this tendency only for the treated group in intermediate-enhancement regions. Regarding kep median values, longitudinal changes were not found for any modality. However, at day 2, kep linked to DCE-US was correlated to MVD in high-enhancement areas for the treated group (p = 0.05). In contrast, correlation to necrosis was detected for the control group in intermediate-enhancement areas (p < 0.1). Intratumoural heterogeneity and longitudinal changes in tumour vasculature were assessed for both modalities. Microvascular parameters derived from DCE-US seem to provide reliable biomarkers during radiotherapy as validated by histology. Furthermore, DCE-US could be a stand-alone or a complementary technique. Copyright © 2015 John Wiley & Sons, Ltd.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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Arteaga-Marrero, ...
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Rygh, C B
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Mainou-Gomez, J ...
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Nylund, K
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Roehrich, D
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Heggdal, J
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visa fler...
-
Matulaniec, P
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Gilja, O H
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Reed, R K
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Svensson, Lena M
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Lutay, Nataliya
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Olsen, D R
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visa färre...
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