Sökning: WFRF:(Remeseiro Silvia)
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Epigenetics, Enhanc...
Epigenetics, Enhancer Function and 3D Chromatin Organization in Reprogramming to Pluripotency
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- Hörnblad, Andreas (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Remeseiro, Silvia (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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(creator_code:org_t)
- 2022-04-21
- 2022
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 11:9
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Genome architecture, epigenetics and enhancer function control the fate and identity of cells. Reprogramming to induced pluripotent stem cells (iPSCs) changes the transcriptional profile and chromatin landscape of the starting somatic cell to that of the pluripotent cell in a stepwise manner. Changes in the regulatory networks are tightly regulated during normal embryonic development to determine cell fate, and similarly need to function in cell fate control during reprogramming. Switching off the somatic program and turning on the pluripotent program involves a dynamic reorganization of the epigenetic landscape, enhancer function, chromatin accessibility and 3D chromatin topology. Within this context, we will review here the current knowledge on the processes that control the establishment and maintenance of pluripotency during somatic cell reprogramming.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- 3D genome
- enhancer
- epigenetics
- iPSCs
- OSKM
- pluripotency
- reprogramming
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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