| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Isfort, I., et al.
(författare)
-
Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. Albeit knowledge on tumorigenesis in mesenchymal tumors is continuously increasing, specific insights on altered signaling pathways as a basis for molecularly targeted therapeutic strategies are still sparse. The aim of this study was to determine the involvement ofYAP1/TAZ-mediated signals in tumors of soft tissue and bone. Expression levels of YAP1 and TAZ were analyzed by immunohistochemistry in a large cohort of 486 tumor specimens, comprising angiosarcomas (AS), Ewing sarcomas, leiomyosarcomas, malignant peripheral nerve sheath tumors (MPNST), solitary fibrous tumors, synovial sarcomas (SySa), well-differentiated/dedifferentiated/ pleomorphic and myxoid liposarcomas (MLS). Moderate to strong nuclear staining ofYAP1 and TAZ was detected in 53% and 33%, respectively. YAP1 nuclear expression was most prevalent in MPNST, SySa and MLS, whereas nuclear TAZ was predominately detected in AS, MLS and MPNST. In a set of sarcoma cell lines, immunoblotting confirmed nuclear localization ofYAP1 and TAZ, corresponding to their transcriptionally active pool. Suppression ofYAP1/TAZ-TEAD mediated transcriptional activity significantly impaired sarcoma cell viability in vitro and in vivo. Our findings identify nuclear YAP1 and TAZ positivity as a common feature in subsets of sarcomas of soft tissue and bone and provide evidence ofYAP1/TAZ-TEAD signaling as a specific liability to be considered as a new target for therapeutic intervention. Nuclear YAP1/TAZ expression may represent a biomarker suited to identify patients that could benefit fromYAP1/TAZ-TEAD directed therapeutic approaches within future clinical trials.
|
|
| 6. |
|
|
| 7. |
- von Geibler, J., et al.
(författare)
-
Identifying business opportunities for green innovations: A quantitative foundation for accelerated micro-fuel cell diffusion in residential buildings
- 2018
-
Ingår i: Energy Reports. - : Elsevier BV. - 2352-4847. ; 4, s. 226-242
-
Tidskriftsartikel (refereegranskat)abstract
- Combined heat and power (CHP) production in buildings is one of the mitigation options available for achieving a considerable decrease in GHG emissions. Micro-CHP (mCHP) fuel cells are capable of cogenerating electricity and heat very efficiently on a decentralised basis. Although they offer clear environmental benefits and have the potential to create a systemic change in energy provision, the diffusion of mCHP fuel cells is rather slow. There are numerous potential drivers for the successful diffusion of fuel cell cogeneration units, but key economic actors are often unaware of them. This paper presents the results of a comprehensive analysis of barriers, drivers and business opportunities surrounding micro-CHP fuel-cell units (up to 5 kWel) in the German building market. Business opportunities have been identified based not only on quantitative data for drivers and barriers, but also on discussions with relevant stakeholders such as housing associations, which are key institutional demand-side actors. These business opportunities include fuel cell contracting as well as the development of a large lighthouse project to demonstrate the climate-neutral, efficient use of fuel cells in the residential building sector. The next step could involve the examination and development of more detailed options and business models. The approach and methods used in the survey may be applied on a larger scale and in other sectors.
|
|
