| 1. |
- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 2. |
- Bianco, Federica B., et al.
(författare)
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Presto-Color : A Photometric Survey Cadence for Explosive Physics and Fast Transients
- 2019
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Ingår i: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 131:1000
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Tidskriftsartikel (refereegranskat)abstract
- We identify minimal observing cadence requirements that enable photometric astronomical surveys to detect and recognize fast and explosive transients and fast transient features. Observations in two different filters within a short time window (e.g., g-and-i, or r-and-z, within <0.5 hr) and a repeat of one of those filters with a longer time window (e.g., >1.5 hr) are desirable for this purpose. Such an observing strategy delivers both the color and light curve evolution of transients on the same night. This allows the identification and initial characterization of fast transient-or fast features of longer timescale transients-such as rapidly declining supernovae, kilonovae, and the signatures of SN ejecta interacting with binary companion stars or circumstellar material. Some of these extragalactic transients are intrinsically rare and generally all hard to find, thus upcoming surveys like the Large Synoptic Survey Telescope (LSST) could dramatically improve our understanding of their origin and properties. We colloquially refer to such a strategy implementation for the LSST as the Presto-Color strategy (rapid-color). This cadence's minimal requirements allow for overall optimization of a survey for other science goals.
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| 3. |
- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 4. |
- de Oliveira, Tiago Elias Castelo, et al.
(författare)
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The Concept of Dynamic Hosting Capacity for Distributed Energy Resources : Analytics and Practical Considerations
- 2019
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Ingår i: Energies. - : MDPI. - 1996-1073. ; 12:13
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Tidskriftsartikel (refereegranskat)abstract
- The hosting capacity approach is presented as a planning, improving, and communication tool for electrical distribution systems operating under specific uncertainties, such as power quality issues, power stabilities, and reliability, among others. In other words, it is an important technique, when renewable sources are present, to answer the amount of power that is possible to supply to the system without trespassing power performance limits. However, the power flow in a distribution system, for instance, can change throughout time due to the penetration of distributed generation, as well as load consumption. Based on the dynamic nature existing in distribution grids nowadays, it is important to highlight that the hosting capacity should not be calculated in a specifically chosen time only, but must be analyzed throughout a period of time. Thus, this paper introduces an extended concept of hosting capacity in relation to an integrated impact of harmonic voltage distortion and voltage rise as a function of time for daily, weekly, monthly, or even yearly periods. This extended concept is named as Dynamic Hosting Capacity (DHC(t)). General aspects of DHC(t) are demonstrated via measured data on a photovoltaic system (PV) connected at a low-voltage (LV) side of a university building.
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| 5. |
- Deshmukh, Amol, et al.
(författare)
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An Empathic Robotic Tutor in a Map Application
- 2015
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Ingår i: Proceedings of the 2015 international conference on autonomous agents & multiagent systems (AAMAS'15). - New York : Association for Computing Machinery (ACM). - 9781450334136 ; , s. 1923-1924
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Konferensbidrag (refereegranskat)abstract
- In this demonstration, we describe a scenario developed in the EMOTE project [2]. The overall goal of the EMOTE project is to develop an empathic robot tutor for 11-13 year old school students in an educational setting. The pedagogical domain we demonstrate here is to assist students in learning and testing their map-reading skills typically learned as part of the geography curriculum in schools. We demonstrate this scenario with a NAO robot interacting with the students whilst performing map-reading tasks in the form of a game on a touch-screen device.
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| 6. |
- Dominguez-Perez, Dany, et al.
(författare)
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Proteomic Analyses of the Unexplored Sea Anemone Bunodactis verrucosa
- 2018
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Ingår i: Marine Drugs. - : MDPI. - 1660-3397. ; 16:2
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Tidskriftsartikel (refereegranskat)abstract
- Cnidarian toxic products, particularly peptide toxins, constitute a promising target for biomedicine research. Indeed, cnidarians are considered as the largest phylum of generally toxic animals. However, research on peptides and toxins of sea anemones is still limited. Moreover, most of the toxins from sea anemones have been discovered by classical purification approaches. Recently, high-throughput methodologies have been used for this purpose but in other Phyla. Hence, the present work was focused on the proteomic analyses of whole-body extract from the unexplored sea anemone Bunodactis verrucosa. The proteomic analyses applied were based on two methods: two-dimensional gel electrophoresis combined with MALDI-TOF/TOF and shotgun proteomic approach. In total, 413 proteins were identified, but only eight proteins were identified from gel-based analyses. Such proteins are mainly involved in basal metabolism and biosynthesis of antibiotics as the most relevant pathways. In addition, some putative toxins including metalloproteinases and neurotoxins were also identified. These findings reinforce the significance of the production of antimicrobial compounds and toxins by sea anemones, which play a significant role in defense and feeding. In general, the present study provides the first proteome map of the sea anemone B. verrucosa stablishing a reference for future studies in the discovery of new compounds.
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| 7. |
- Hall, Lynne, et al.
(författare)
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Map reading with an empathic robot tutor
- 2016
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Ingår i: ACMIEEE International Conference on Human-Robot Interaction. - Piscataway, NJ : IEEE. - 2167-2121. - 9781467383707
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Konferensbidrag (refereegranskat)
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| 8. |
- Jugend, Daniel, et al.
(författare)
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The role of cross-functional integration in new product development : Differences between incremental and radical innovation projects
- 2018
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Ingår i: Innovation: Organization & Management. - : Taylor & Francis. - 1447-9338 .- 2204-0226. ; 20:1, s. 42-60
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Tidskriftsartikel (refereegranskat)abstract
- The literature on new product development (NPD) contains several studies of management practices involved in different types of innovation. However, few studies focus on how cross-functional integration affects incremental and radical innovation product projects. The purpose of this study is to explore this aspect, from a qualitative perspective, through case studies of four high-tech firms in Brazil. Eight NPD projects were studied. The findings suggest that radical and incremental innovation NPD projects require different management practices in the studied cases. In incremental NPD projects, greater integration efforts may not be necessary. However, the following practices should be adopted in projects involving radical innovation product projects: intense involvement of technical teams, flexibility in the early stages of NPD, and geographical separation between the development team and other departments of the firm. Moreover, the application of these same practices in projects of incremental innovation in NPD may not bring positive results.
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| 9. |
- Ribeiro-Barros, Ana I., et al.
(författare)
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An integrated approach to understand the mechanisms underlying salt stress tolerance in Casuarina glauca and its relation with nitrogen-fixing Frankia Thr
- 2016
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Ingår i: Symbiosis. - : Springer Science and Business Media LLC. - 0334-5114 .- 1878-7665. ; 70:1, s. 111-116
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Tidskriftsartikel (refereegranskat)abstract
- Salinity is one of the most wide spread abiotic stresses affecting agricultural productivity, with an impact on more than 800 million hectares worldwide. A promising solution for the recovery of saline soils encompasses the use of actinorhizal plants, a group of perennial dicotyledonous angiosperms including species highly resilient to extreme environmental conditions. These plants are able to establish root-nodule symbiosis with N-2-fixing actinobacteria of the genus Frankia. In this review, we discuss the main physiological and biochemical mechanisms underlying salt tolerance in the model Casuarina glauca supplemented with chemical nitrogen or obtaining it from symbiotic Frankia. In the first part, an overview of the impact of increasing NaCl concentrations in photosynthesis, antioxidative system and membrane integrity is presented. The second part addresses the effect of salt stress in the symbiosis between C. glauca and Frankia strain Thr. Preliminary results from analyses of the branchlets proteome and nodule metabolome are presented as well.
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| 10. |
- Ribeiro, Tiago, et al.
(författare)
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Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
- 2017
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- Portoamides are cyclic peptides produced and released by the cyanobacterial strain Phormidium sp. presumably to interfere with other organisms in their ecosystems (" allelopathy"). Portoamides were previously demonstrated to have an antiproliferative effect on human lung carcinoma cells, but the underlying mechanism of this activity has not been described. In the present work, the effects of portoamides on proliferation were examined in eight human cancer cell lines and two non-carcinogenic cell lines, and major differences in sensitivities were observed. To generate hypotheses with regard to molecular mechanisms of action, quantitative proteomics using 2D gel electrophoresis and MALDI-TOF/ TOF were performed on the colon carcinoma cell line HT-29. The expression of proteins involved in energy metabolism (mitochondrial respiratory chain and pentose phosphate pathway) was found to be affected. The hypothesis of altered energy metabolism was tested in further experiments. Exposure to portoamides resulted in reduced cellular ATP content, likely due to decreased mitochondrial energy production. Mitochondrial hyperpolarization and reduced mitochondrial reductive capacity was observed in treated cells. Furthermore, alterations in the expression of peroxiredoxins (PRDX4, PRDX6) and components of proteasome subunits (PSB4, PSA6) were observed in portoamide-treated cells, but these alterations were not associated with detectable increases in oxidative stress. We conclude that the cytotoxic activity of portoamides is associated with disturbance of energy metabolism, and alterations in mitochondrial structure and function.
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