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Tissue viscoelastic...
Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone – An experimental and finite element study
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- Ojanen, X. (författare)
- University of Eastern Finland
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- Tanska, P. (författare)
- University of Eastern Finland
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- Malo, M. K.H. (författare)
- University of Eastern Finland
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- Isaksson, H. (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
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- Väänänen, S. P. (författare)
- Kuopio University Hospital,University of Eastern Finland
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- Koistinen, A. P. (författare)
- University of Eastern Finland
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- Grassi, L. (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Magnusson, S. P. (författare)
- University of Copenhagen,Bispebjerg Hospital
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- Ribel-Madsen, S. M. (författare)
- University of Copenhagen
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- Korhonen, R. K. (författare)
- University of Eastern Finland,Kuopio University Hospital
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- Jurvelin, J. S. (författare)
- University of Eastern Finland
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- Töyräs, J. (författare)
- Kuopio University Hospital,University of Eastern Finland
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska 10 s.
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Ingår i: Journal of Biomechanics. - : Elsevier BV. - 0021-9290. ; 65, s. 96-105
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Trabecular bone is viscoelastic under dynamic loading. However, it is unclear how tissue viscoelasticity controls viscoelasticity at the apparent-level. In this study, viscoelasticity of cylindrical human trabecular bone samples (n = 11, male, age 18–78 years) from 11 proximal femurs were characterized using dynamic and stress-relaxation testing at the apparent-level and with creep nanoindentation at the tissue-level. In addition, bone tissue elasticity was determined using scanning acoustic microscope (SAM). Tissue composition and collagen crosslinks were assessed using Raman micro-spectroscopy and high performance liquid chromatography (HPLC), respectively. Values of material parameters were obtained from finite element (FE) models by optimizing tissue-level creep and apparent-level stress-relaxation to experimental nanoindentation and unconfined compression testing values, respectively, utilizing the second order Prony series to depict viscoelasticity. FE simulations showed that tissue-level equilibrium elastic modulus (Eeq) increased with increasing crystallinity (r = 0.730, p =.011) while at the apparent-level it increased with increasing hydroxylysyl pyridinoline content (r = 0.718, p =.019). In addition, the normalized shear modulus g1 (r = −0.780, p =.005) decreased with increasing collagen ratio (amide III/CH2) at the tissue-level, but increased (r = 0.696, p =.025) with increasing collagen ratio at the apparent-level. No significant relations were found between the measured or simulated viscoelastic parameters at the tissue- and apparent-levels nor were the parameters related to tissue elasticity determined with SAM. However, only Eeq, g2 and relaxation time τ1 from simulated viscoelastic values were statistically different between tissue- and apparent-levels (p <.01). These findings indicate that bone tissue viscoelasticity is affected by tissue composition but may not fully predict the macroscale viscoelasticity in human trabecular bone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Collagen crosslink
- Composition
- Finite element modeling
- Trabecular bone
- Viscoelasticity
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ojanen, X.
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Tanska, P.
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Malo, M. K.H.
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Isaksson, H.
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Väänänen, S. P.
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Koistinen, A. P.
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visa fler...
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Grassi, L.
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Magnusson, S. P.
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Ribel-Madsen, S. ...
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Korhonen, R. K.
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Jurvelin, J. S.
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Töyräs, J.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Fysiologi
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
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Journal of Biome ...
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Lunds universitet