Sökning: WFRF:(Ribera F)
> (2005-2009) >
Mitochondrial tissu...
Mitochondrial tissue specificity of substrates utilization in rat cardiac and skeletal muscles
-
- Ponsot, Elodie, 1973- (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France; Hôpital Civil de Strasbourg, Serv. Explorations Fonctionnelles R., 1 place de l'hôpital, Strasbourg Cedex, France
-
- Zoll, J (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France
-
- N'guessan, B (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France
-
visa fler...
-
- Ribera, F (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France
-
- Lampert, E (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France
-
- Richard, R (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France
-
- Veksler, V (författare)
- Service de Cardiologie, Hôpitaux Civils de Colmar, Colmar Cedex, France
-
- Ventura-Clapier, R (författare)
- U-446 INSERM, Faculté de Pharmacie, Châtenay-Malabry, France
-
- Mettauer, B (författare)
- Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France; Service de Cardiologie, Hôpitaux Civils de Colmar, Colmar Cedex, France
-
visa färre...
-
Serv Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France; Hôpital Civil de Strasbourg, Serv. Explorations Fonctionnelles R., 1 place de l'hôpital, Strasbourg Cedex, France Serv. Explorations Fonctionnelles R., Département de Physiologie, Strasbourg, France (creator_code:org_t)
- 2005
- 2005
- Engelska.
-
Ingår i: Journal of Cellular Physiology. - Hoboken, USA : John Wiley & Sons. - 0021-9541 .- 1097-4652. ; 203:3, s. 479-86
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- As energetic metabolism is crucial for muscles, they develop different adaptations to respond to fluctuating demand among muscle types. Whereas quantitative characteristics are known, no study described simultaneously quantitative and qualitative differences among muscle types in terms of substrates utilization patterns. This study thus defined the pattern of substrates preferential utilization by mitochondria from glycolytic gastrocnemius (GAS) and oxidative soleus (SOL) skeletal muscles and from heart left ventrical (LV) in rats. We measured in situ, ADP (2 mM)-stimulated, mitochondrial respiration rates from skinned fibers in presence of increasing concentrations of pyruvate (Pyr) + malate (Mal), palmitoyl-carnitine (Palm-C) + Mal, glutamate (Glut) + Mal, glycerol-3-phosphate (G3-P), lactate (Lact) + Mal. Because the fibers oxygen uptake (Vs) followed Michaelis-Menten kinetics in function of substrates level we determined the Vs and Km, representing maximal oxidative capacity and the mitochondrial sensibility for each substrate, respectively. Vs were in the order GAS < SOL < LV for Pyr, Glu, and Palm-C substrates, whereas in the order SOL = LV < GAS with G3-P. Moreover, the relative capacity to oxidize Palm-C is extremely higher in LV than in SOL. Vs was not stimulated by the Lact substrate. The Km was equal for Pyr among muscles, but much lower for G3-P in GAS and lower for Palm-C in LV. These results demonstrate qualitative mitochondrial tissue specificity for metabolic pathways. Mitochondria of glycolytic muscle fibers are well adapted to play a central role for maintaining a satisfactory cytosolic redox state in these fibers, whereas mitochondria of LV developed important capacities to use fatty acids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Idrottsvetenskap
- Sports Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ponsot, Elodie, ...
-
Zoll, J
-
N'guessan, B
-
Ribera, F
-
Lampert, E
-
Richard, R
-
visa fler...
-
Veksler, V
-
Ventura-Clapier, ...
-
Mettauer, B
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Idrottsvetenskap
- Artiklar i publikationen
-
Journal of Cellu ...
- Av lärosätet
-
Örebro universitet