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- Caberlotto, L, et al.
(författare)
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Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases
- 2019
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 3965-
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Tidskriftsartikel (refereegranskat)abstract
- Evidence is accumulating that the main chronic diseases of aging Alzheimer’s disease (AD) and type-2 diabetes mellitus (T2DM) share common pathophysiological mechanisms. This study aimed at applying systems biology approaches to increase the knowledge of the shared molecular pathways underpinnings of AD and T2DM. We analysed transcriptomic data of post-mortem AD and T2DM human brains to obtain disease signatures of AD and T2DM and combined them with protein-protein interaction information to construct two disease-specific networks. The overlapping AD/T2DM network proteins were then used to extract the most representative Gene Ontology biological process terms. The expression of genes identified as relevant was studied in two AD models, 3xTg-AD and ApoE3/ApoE4 targeted replacement mice. The present transcriptomic data analysis revealed a principal role for autophagy in the molecular basis of both AD and T2DM. Our experimental validation in mouse AD models confirmed the role of autophagy-related genes. Among modulated genes, Cyclin-Dependent Kinase Inhibitor 1B, Autophagy Related 16-Like 2, and insulin were highlighted. In conclusion, the present investigation revealed autophagy as the central dys-regulated pathway in highly co-morbid diseases such as AD and T2DM allowing the identification of specific genes potentially involved in disease pathophysiology which could become novel targets for therapeutic intervention.
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| 2. |
- Chiesa, Marco, 1987-, et al.
(författare)
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PrIXP : Preserving the privacy of routing policies at Internet eXchange Points
- 2017
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Ingår i: Proceedings of the IM 2017 - 2017 IFIP/IEEE International Symposium on Integrated Network and Service Management. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 435-441
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Konferensbidrag (refereegranskat)abstract
- Internet eXchange Points (IXPs) serve as landmarks where many network service providers meet to obtain reciprocal connectivity. Some of them, especially the largest, offer route servers as a convenient technology to simplify the setup of a high number of bi-lateral peerings. Due to their potential to support a quick and easy interconnection among the networks of multiple providers, IXPs are becoming increasingly popular and widespread, and route servers are exploited increasingly often. However, in an ever-growing level of market competition, service providers are pushed to develop concerns about many aspects that are strategic for their business, ranging from commercial agreements with other members of an IXP to the policies that are adopted in exchanging routing information with them. Although these aspects are notoriously sensitive for network service providers, current IXP architectures offer no guarantees to enforce the privacy of such business-critical information. We re-design a traditional route server and propose an approach to enforce the privacy of peering relationships and routing policies that it manages. Our proposed architecture ensures that nobody, not even a third party, can access such information unless it is the legitimate owner (i.e., the IXP member that set up the policy), yet allowing the route server to apply the requested policies and each IXP member to verify that such policies have been correctly deployed. We implemented the route server and tested our solutions in a simulated environment, tracking and analyzing the number of exchanged control plane messages.
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