| 1. |
- Janczewska, Izabella, et al.
(författare)
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Clinical application of the multigene analysis test in discriminating between ulcerative colitis and Crohn's disease : a retrospective study
- 2012
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Ingår i: Scandinavian journal of gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 47:2, s. 162-9
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Methods. The newly described - multigene analysis test (DiBiCol) identifying 7 inflammatory bowel disease (IBD)-specific genes in colonic mucosal biopsy differentiating between ulcerative colitis (UC) and Crohn's disease (CD) with active inflammation - is a new addition to existing methods with a higher stated sensitivity and specificity. Method biopsy material from 78 patients with a complicated course diagnosed as most probably UC in 38, CD in 18 and inflammatory bowel disease unclassified (IBDU) in 22 were investigated by DiBiCol. Results. DiBiCol showed a pattern consistent with CD in 13 patients with UC and led to change of diagnosis in 3 patients and a strong suggestion of CD in 8 patients. A total of 2 patients remained as UC. DiBiCol showed a pattern of UC in 4 patients of 18 with CD leading to a changing of diagnosis to UC in 3 patients, but the fourth remained as CD. In 22 patients with IBDU DiBiCol showed a pattern consistent with UC in 7 cases and with CD in 13 cases. A new evaluation 1 year after the DiBiCol allowed the assessment of clinical diagnosis in 10 patients confirmed in 9 of 10 patients by DiBiCol. In patients with acute flare of colitis the clinical diagnosis corresponded in 10 of 12 UC and in 5 of 6 CD cases. Summary. Adopting the DiBiCol test led to a change of the primary diagnosis in a significant number of patients with the initial diagnosis of UC and CD and suggested a clinically probable diagnosis in most of the patients with IBDU and in those with an acute flare of colitis.
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| 2. |
- Jeppsson, B, et al.
(författare)
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Kirurgi.
- 2010
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Bok (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Öberg, Helena, 1974-, et al.
(författare)
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A diatom record of recent environmental change in Lake Duluti, northern Tanzania
- 2012
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Ingår i: Journal of Paleolimnology. - : Springer Science and Business Media LLC. - 0921-2728 .- 1573-0417. ; 48:2, s. 401-416
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Tidskriftsartikel (refereegranskat)abstract
- Lake Duluti is a small, topographically closed crater lake located on the flanks of Mt Meru, northern Tanzania. Analyses of diatoms in three short sediment cores and four modern samples from Lake Duluti were used to infer past environmental changes. 210Pb and 137Cs activity profiles combined with AMS 14C dates provide the chronological framework. Weak agreement between the 210Pb and 14C records, together with dating uncertainty, precludes construction of precise age models. The modern diatom flora, from plankton and three periphytic habitats, is dominated by Aulacoseira ambigua (Grunow) Simonsen, Gomphonema parvulum (Kützing) Grunow and Nitzschia amphibia Grunow. All three cores display similar stratigraphic succession, but the relative ratio of habitats represented by the diatoms varies substantially between cores. Diatoms indicate that the oldest part of the record is characterized by relatively low lake level and swampy vegetation. In the late nineteenth or early twentieth century there was a rapid lake level rise and the swamp turned into an open-water lake. High lake levels have prevailed since that time.
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| 4. |
- Öberg, Helena, et al.
(författare)
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Environmental variability in northern Tanzania from AD 1000 to 1800, as inferred from diatoms and pollen in Lake Duluti
- 2013
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182 .- 1872-616X. ; 374, s. 230-241
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Tidskriftsartikel (refereegranskat)abstract
- Fossil pollen and diatoms have been analyzed in a sediment sequence from a topographically closed crater lake in northern Tanzania (Lake Duluti), with the aim to reconstruct past changes in lake level and vegetation dynamics. The results provide a new paleoenvironmental record from equatorial Africa covering the period c. AD 1000 to AD 1800. Overall, the pollen and diatom records generate comparable stories of dry and wet periods. Dry conditions are inferred at c. AD 1040-1470, c. AD 1510-1640 and C. AD 1650-1670 with the lowest lake levels at c. AD 1260-1290 and AD 1600-1640. Wetter conditions occurred c. AD 1640-1650 and c. AD 1670-1790. The chronology is based on combined analyses of Pb-210 activity and AMS C-14 on bulk sediment, and a Bayesian model was applied to establish the age-depth relationship. The hydroclimatic record from Lake Duluti shows good correlation with several East African lakes in a centennial time perspective, although comparison of high frequency variability in the region is hampered by dating uncertainties.
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