| 1. |
- Rodrigues, Mariana Teixeira, et al.
(författare)
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Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer
- 2023
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Ingår i: Pharmaceuticals. - : MDPI. - 1424-8247. ; 16:12
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Tidskriftsartikel (refereegranskat)abstract
- Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise. Therefore, this study aimed to explore the antineoplastic effects of lysicamine in papillary TC (BCPAP) and ATC (HTH83 and KTC-2) cells. Lysicamine treatment reduced cell viability, motility, colony formation, and AKT activation while increasing the percentage of necrotic cells. The absence of caspase activity confirmed apoptosis-independent cell death. Necrostatin-1 (NEC-1)-mediated necrosome inhibition reduced lysicamine-induced necrosis in KTC-2, suggesting necroptosis induction via a reactive oxygen species (ROS)-independent mechanism. Additionally, in silico analysis predicted lysicamine target proteins, particularly those related to MAPK and TGF-beta signaling. Our study demonstrated lysicamine's potential as an antineoplastic compound in ATC cells with a proposed mechanism related to inhibiting AKT activation and inducing cell death.
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| 2. |
- Guo, Zhiwei, et al.
(författare)
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Deep Federated Learning Enhanced Secure POI Microservices for Cyber-Physical Systems
- 2022
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Ingår i: IEEE wireless communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1284 .- 1558-0687. ; 29:2, s. 22-29
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Tidskriftsartikel (refereegranskat)abstract
- An essential consideration in cyber-physical systems (CPS) is the ability to support secure communication services, such as points of interest (POI) microservices. Existing approaches to support secure POI microservices generally rely on anonymity and/or differential privacy technologies. There are, however, a number of known limitations with such approaches. Hence, this work presents a deep-federated-learning-based framework for securing POI microservices in CPS. In order to enhance data security, the system architecture is designed to isolate the cloud center from accessing user data on edge nodes, and an interactive training mechanism is introduced between the cloud center and edge nodes. Specifically, edge nodes pre-train reliable deep-learning-based models for users, and the cloud server coordinates parameter updating via federated learning. The connected and isolated structure between cloud center and edges facilitates deep federated learning. Finally, we implement and evaluate the performance of our proposed approach using two real-world POI-related datasets. The results show that our proposed approach achieves optimal scheduling performance and demonstrates its practical utility.
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| 3. |
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| 4. |
- Memon, Shuaib K., et al.
(författare)
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A survey on 802.11 MAC protocols industrial standards, architecture elements for providing QoS guarantee, supporting emergency traffic, and security : Future directions
- 2021
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Ingår i: Journal of Industrial Information Integration. - : Elsevier BV. - 2467-964X .- 2452-414X. ; 24:Dec 2021
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Tidskriftsartikel (refereegranskat)abstract
- The IEEE 802.11-based Wireless Local Area Network (WLAN) has become a ubiquitous networking technology deployed around the world. IEEE 802.11 WLAN are now widely used for real-time multimedia applications (e.g. voice and video streaming) and distributed emergency services such as telemedicine, healthcare, and disaster recovery. Both time-sensitive applications and emergency traffic are not only characterized by their high bandwidth requirements, but also impose severe restrictions on end-to-end packet delays (i.e. response time), jitter (i.e. delay variance) and packet losses. In other words, time-sensitive applications and emergency services require a strict Quality of Service (QoS) guarantee. Medium Access Control (MAC) protocol is one of the key factors that influence the performance of WLANs. The IEEE 802.11e working group enhanced the 802.11 MAC to provide QoS support in WLANs. However, recent studies have shown that 802.11e Enhanced Distributed Channel Access (EDCA) standard has limitations and it neither supports strict QoS guarantee nor emergency traffic. Providing a strict QoS guarantee as well as supporting emergency traffic under high traffic loads is really a challenging task in WLANs. A thorough review of literature on QoS MAC protocols reveals that most QoS schemes have focused on either network throughput enhancement or service differentiation by adjusting Contention Window (CW) or Inter-Frame Spaces (IFS). Therefore, a research on developing techniques to provide a strict QoS guarantee as well as support for emergency traffic is required in such systems. To achieve this objective, a general understanding of WLANs is required. This paper aims introduce various key concepts of WLANs that are necessary for design, model and develop such framework. Our main contribution in this paper is the QoS for IEEE 802.11 WLAN and MAC protocols for supporting industrial emergency traffic over network and future directions.
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| 5. |
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| 6. |
- Sodhro, Ali Hassan, et al.
(författare)
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Link Optimization in Software Defined IoV driven Autonomous Transportation System
- 2021
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Ingår i: IEEE Transactions on Intelligent Transportation Systems. - : IEEE. - 1524-9050 .- 1558-0016. ; 22:6, s. 3511-3520
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Tidskriftsartikel (refereegranskat)abstract
- Due to the high mobility, dynamic nature, and legacy vehicular networks, the seamless connectivity and reliability become a new challenge in software-defined internet of vehicles based intelligent transportation systems (ITS). Thus, effieicnt optimization of the link with proper monitoring of the high speed of vehicles in ITS is very vital to promote the error-free and trustable platform. Key issues related to reliability, connectivity and stability optimization for vehicular networks are addressed. Thus, this study proposes a novel reliable connectivity framework by developing a stable, and scalable link optimization (SSLO) algorithm, state-of-the-art system model. In addition, a Use-case of smart city with stable and reliable connectivity is proposed by examining the importance of vehicular networks. The numerical experimental results are extracted from software defined-Internet of Vehicle (SD-IoV) platform which shows high stability and reliability of the proposed SSLO under different test scenarios, such as vehicle to vehicle (V2V), vehicle to infrastructure (V2I) and vehicle to anything (V2X). The proposed SSLO and Baseline algorithms are compared in terms of performance metrics e.g. packet loss ratio, transmission power (i.e., stability), average throughput, and average delay transfer. Finally, the validated results reveal that SSLO algorithm optimizes connectivity (95%), energy efficiency (67%), throughput (4Kbps) and delay (3 sec).
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| 7. |
- Ursing, Johan, et al.
(författare)
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High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children
- 2020
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Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 64:3
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Tidskriftsartikel (refereegranskat)abstract
- Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10 mg/kg of chloroquine twice daily for 2 days and 5 mg/kg twice daily on the third day. Fifteen additional children were given 5 mg/kg twice daily for 2 more days. Chloroquine concentrations, blood pressure, electrocardiograms (ECGs), parasite density, and adverse events were assessed until day 28. Both dosages were well tolerated, and symptoms resolved by day 3 in parallel with increasing chloroquine concentrations. The median corrected QT (QTc) interval was 12 to 26 ms higher at expected peak concentrations than at day 0 (P < 0.001). Pfcrt 76T was associated with delayed parasite clearance. Day 28 clinical and parasitological responses against P. falciparum with pfcrt 76T were 57% (4/7) and 67% (4/6) after treatment with 50 and 70 mg/kg, respectively. Dosages were well tolerated, and no severe cardiac adverse events occurred. The QTc interval increase was similar to that found in adults taking 25 mg/kg of chloroquine.
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