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- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 2. |
- Vissers, Gregal J. M., et al.
(författare)
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Non-LTE inversions of a confined X2.2 flare I. The vector magnetic field in the photosphere and chromosphere
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 645
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Tidskriftsartikel (refereegranskat)abstract
- Context. Obtaining an accurate measurement of magnetic field vector in the solar atmosphere is essential for studying changes in field topology during flares and reliably modelling space weather.Aims. We tackle this problem by applying various inversion methods to a confined X2.2 flare that occurred in NOAA AR 12673 on 6 September 2017 and comparing the photospheric and chromospheric magnetic field vector with the results of two numerical models of this event.Methods. We obtained the photospheric magnetic field from Milne-Eddington and (non-)local thermal equilibrium (non-LTE) inversions of Hinode SOT/SP FeI 6301.5 angstrom and 6302.5 angstrom. The chromospheric field was obtained from a spatially regularised weak-field approximation (WFA) and non-LTE inversions of CaII 8542 angstrom observed with CRISP at the Swedish 1 m Solar Telescope. We investigated the field strengths and photosphere-to-chromosphere shear in the field vector.Results. The LTE- and non-LTE-inferred photospheric magnetic field components are strongly correlated across several optical depths in the atmosphere, with a tendency towards a stronger field and higher temperatures in the non-LTE inversions. For the chromospheric field, the non-LTE inversions correlate well with the spatially regularised WFA, especially in terms of the line-of-sight field strength and field vector orientation. The photosphere exhibits coherent strong-field patches of over 4.5 kG, co-located with similar concentrations exceeding 3 kG in the chromosphere. The obtained field strengths are up to two to three times higher than in the numerical models, while the photosphere-to-chromosphere shear close to the polarity inversion line is more concentrated and structured.Conclusions. In the photosphere, the assumption of LTE for FeI line formation does not yield significantly different magnetic field results in comparison to the non-LTE case, while Milne-Eddington inversions fail to reproduce the magnetic field vector orientation where FeI is in emission. In the chromosphere, the non-LTE-inferred field is excellently approximated by the spatially regularised WFA. Our inversions confirm the locations of flux rope footpoints that have been predicted by numerical models. However, pre-processing and lower spatial resolution lead to weaker and smoother field in the models than what our data indicate. This highlights the need for higher spatial resolution in the models to better constrain pre-eruptive flux ropes.
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