| 1. |
- Anneling, Roger, et al.
(författare)
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Höga upplagstryck
- 1990
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Rapport (refereegranskat)
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| 2. |
- Berg, Roger, et al.
(författare)
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Time-resolved tranillumination imaging
- 1993
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Ingår i: Medical Optical Tomography: Functional Imaging and Monitoring. ; , s. 397-424
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Bokkapitel (refereegranskat)
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| 3. |
- Franzén, Lars, et al.
(författare)
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Fractionated-irradiation and late changes in rat parotid-gland : effects on the number of acinar-cells, potassium efflux, and amylase secretion
- 1993
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 64:1, s. 93-101
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Tidskriftsartikel (refereegranskat)abstract
- Irradiation of head- and neck cancer commonly results in oral dryness and discomfort for the patients due to salivary gland damage. The exact mechanisms behind the inherent radiosensitivity of salivary glands remain to be elucidated. In the present study, we used different in vitro secretory models and quantitative morphological characterization of rat parotid gland following fractionated unilateral irradiation to one gland on a 5-day fraction schedule (Monday-Friday) with 6 MV photons (total dose 30, 35, 40 and 45 Gy) or a two-fractions regimen in 5 days (Monday and Friday) with total dose of 24 and 32 Gy. The contralateral shielded gland served as control, and parallel analyses of irradiated and control glands were performed 180 days following the last irradiation treatment. The relative noradrenaline stimulated electrolyte secretion (rubidium-86 tracer for potassium) was decreased in the irradiated compared with control glands. The noradrenaline-stimulated exocytotic amylase release was not significantly affected by irradiation, but the gland content of amylase was decreased dose-dependently. The quantitative morphological analysis revealed a dose-dependent decline in the number of acinar cells, whereas the other parenchymal cells (intercalated, striated- and excretory duct cells) were un-, affected by the irradiation compared with control glands.
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| 4. |
- Karlsson, Roger, et al.
(författare)
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A chicken beta-actin gene can complement a disruption of the Saccharomyces cerevisiae ACT1 gene
- 1991
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Ingår i: Molecular and Cellular Biology. - : American Society for Microbiology. - 0270-7306 .- 1098-5549. ; 11:1, s. 213-217
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Tidskriftsartikel (refereegranskat)abstract
- Recently it was demonstrated that beta-actin can be produced in Saccharomyces cerevisiae by using the expression plasmid pY beta actin (R. Karlsson, Gene 68:249-258, 1988), and several site-specific mutants are now being produced in a protein engineering study. To establish a system with which recombinant actin mutants can be tested in vivo and thus enable a correlation to be made with functional effects observed in vitro, a yeast strain lacking endogenous yeast actin and expressing exclusively beta-actin was constructed. This strain is viable but has an altered morphology and a slow-growth phenotype and is temperature sensitive to the point of lethality at 37 degrees C.
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| 5. |
- Warkentin, Siegbert, et al.
(författare)
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Redistribution of blood flow in the cerebral cortex of normal subjects during head-up postural change
- 1992
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Ingår i: Clinical autonomic research : official journal of the Clinical Autonomic Research Society. ; 2:2, s. 119-24
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Tidskriftsartikel (refereegranskat)abstract
- Regional cerebral blood flow was measured in 21 normotensive subjects during supine rest and during head-up tilt to 70 degrees. The results showed significant and consistent regional cerebral blood flow changes in the frontal areas with lower relative flow distribution values (percentage of mean flow) during head-up tilt than during supine rest. The lower frontal flow distribution values during tilt were not related to habituation, to repeated measurements, or to the estimated level of arterial CO2 which was derived from expired end-tidal CO2 levels. None of the subjects had orthostatic hypotension and there was no significant difference in mean hemispheric blood flow between lying down and standing up. There was no significant gender difference in regional cerebral blood flow, although female subjects tended to have higher mean hemispheric flow than males in both postures. It remains to be established whether the flow decreases in the frontal cortex are caused by cerebral functional factors or by haemodynamic mechanisms.
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