Search: WFRF:(Rogge Barbara P.)
> (2018) >
Natural variation i...
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
-
- Patin, Etienne (author)
- Pasteur Institute
-
- Hasan, Milena (author)
- Pasteur Institute
-
- Bergstedt, Jacob (author)
- Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,Pasteur Institute
-
show more...
-
- Rouilly, Vincent (author)
- Pasteur Institute
-
- Libri, Valentina (author)
- Pasteur Institute
-
- Urrutia, Alejandra (author)
- Pasteur Institute,Genentech, Inc
-
- Alanio, Cécile (author)
- Pasteur Institute
-
- Scepanovic, Petar (author)
- Swiss Federal Institute of Technology,Swiss Institute for Bioinformatics (SIB)
-
- Hammer, Christian (author)
- Swiss Institute for Bioinformatics (SIB),Swiss Federal Institute of Technology
-
- Jönsson, Friederike (author)
- Swiss Federal Institute of Technology
-
- Beitz, Benoît (author)
- Pasteur Institute
-
- Quach, Helene (author)
- Pasteur Institute
-
- Lim, Yoong Wearn (author)
- Genentech, Inc
-
- Hunkapiller, Julie (author)
- Genentech, Inc
-
- Zepeda, Magge (author)
- Genentech, Inc
-
- Green, Cherie (author)
- Genentech, Inc
-
- Piasecka, Barbara (author)
- Pasteur Institute
-
- Leloup, Claire (author)
- Genentech, Inc
-
- Rogge, Lars (author)
- Pasteur Institute
-
- Huetz, François (author)
- Paris Descartes University,Pasteur Institute
-
- Peguillet, Isabelle (author)
- Curie Institute, Paris
-
- Lantz, Olivier (author)
- Curie Institute, Paris
-
- Fontes, Magnus (author)
- Lund University,Lunds universitet,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH,Pasteur Institute
-
- Santo, James P. (author)
- Pasteur Institute
-
- Thomas, Stéphanie (author)
- Pasteur Institute
-
- Fellay, Jacques (author)
- Swiss Federal Institute of Technology,Genentech, Inc
-
- Duffy, Darragh (author)
- Pasteur Institute
-
- Quintana-Murci, Lluis (author)
- Pasteur Institute
-
- Albert, Matthew L (author)
- Pasteur Institute,Genentech, Inc
-
show less...
-
(creator_code:org_t)
-
- 2018-02-23
- 2018
- English.
-
In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 19, s. 302-314
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://hal-pasteur....
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Patin, Etienne
-
Hasan, Milena
-
Bergstedt, Jacob
-
Rouilly, Vincent
-
Libri, Valentina
-
Urrutia, Alejand ...
-
show more...
-
Alanio, Cécile
-
Scepanovic, Peta ...
-
Hammer, Christia ...
-
Jönsson, Frieder ...
-
Beitz, Benoît
-
Quach, Helene
-
Lim, Yoong Wearn
-
Hunkapiller, Jul ...
-
Zepeda, Magge
-
Green, Cherie
-
Piasecka, Barbar ...
-
Leloup, Claire
-
Rogge, Lars
-
Huetz, François
-
Peguillet, Isabe ...
-
Lantz, Olivier
-
Fontes, Magnus
-
Santo, James P.
-
Thomas, Stéphani ...
-
Fellay, Jacques
-
Duffy, Darragh
-
Quintana-Murci, ...
-
Albert, Matthew ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Nature Immunolog ...
- By the university
-
Lund University