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- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 2. |
- Cavero Olguin, Victor Hugo, et al.
(författare)
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Stress induced biofilm formation in Propionibacterium acidipropionici and use in propionic acid production.
- 2019
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Ingår i: World Journal of Microbiology and Biotechnology. - : Springer Science and Business Media LLC. - 0959-3993 .- 1573-0972. ; 35:101
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Tidskriftsartikel (refereegranskat)abstract
- Propionibacterium acidipropionici produces propionic acid from different sugars and glycerol; the production can be improved by high cell density fermentations using immobilized cells that help to overcome the limitations of the non-productive lag phase and product inhibition. In this study, the use of stress factors to induce P. acidipropionici to form biofilm and its use as an immobilization procedure in fermentations in bioreactors for producing propionic acid was investigated. Citric acid and sodium chloride increased exopolysaccharide production, biofilm capacity index and trehalose production. Analysis of the expression of trehalose synthesis-related genes otsA and treY by RT-qPCR showed significantly increased expression of only treY during log phase with citric acid, while FISH analysis showed expression of treY and luxS under the influence of both stress factors. The stress factors were then used for development of microbial biofilms as immobilization procedure on Poraver® and AnoxKaldnes® carriers in recycle batch reactors for propionic acid production from 20 g/L glycerol. Highest productivities of 0.7 and 0.78 g/L/h were obtained in Poraver® reactors, and 0.39 and 0.43 g/L/h in AnoxKaldnes® reactors with citric acid and NaCl, respectively.
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| 3. |
- Romero Fernández, Alejandro, et al.
(författare)
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¿Crisis de la ciencia o crisis civilizatoria?
- 2018
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Ingår i: Crisis de mundo: Perspectivas filosóficas (preliminar title). - 9789875749870
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- En este trabajo planteamos cuales son las formas particulares que toma en ciencia la crisis de la civilización. Formas que no siempre son fáciles de advertir. Crisis de la ciencia que es causa y consecuencia de la crisis civilizatoria. Partimos de observaciones realizadas dentro del campo científico que indican un fuerte retroceso de la razón crítica en ciencia quedando vigente solamente la razón instrumental y en ocasiones menos aún: un empirismo sin razón. Exponemos el proceso de extinción de la ciencia en su continua y activa metamorfosis como tecnociencia, próxima ya a emerger en la forma pura de tecnología. Es decir, el abandono del saber (episteme) por el saber hacer (techné). El abandono del ideal del cosmos o de la unidad de la razón por la noción de éxito como principio orientador de la labor de los pensadores. Señalamos asimismo las formas sociales por las que se reproduce la tecnociencia y la mutilación de la razón. Finalmente proponemos mínimas acciones para frenar o revertir este proceso.
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