| 1. |
- Back, Par-Erik, et al.
(författare)
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Hållbarhetsanalys i avhjälpandeprocessen för förorenade områden - Principer och lärdomar från forskningsprojektet SAFIRE
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Forskningsprojektet SAFIRE genomfördes under åren 2015–2018. Projektets övergripande syfte var att utvärdera hur hållbarhetsbedömningar kan förbättra effektiviteten vid avhjälpande av föroreningsskador vid förorenade områden i Sverige. Bakgrunden till projektet var bland annat den låga saneringstakten i landet, de ofta höga kostnaderna för avhjälpande åtgärder samt åtgärdernas negativa effekter. Ett viktigt moment i avhjälpandeprocessen är att identifiera det åtgärdsalternativ som är bäst och det är rimligt att denna bedömning baseras på hållbarhet, vilket är det synsätt som tillämpats i forskningsprojektet. I arbetspaketet WP3, Incorporation of sustainability assessment in the remediation process, har lärdomarna från bland annat fallstudier använts för att utvärdera hållbarhetsanalysernas roll i avhjälpandeprocessen. Resultatet av detta arbete presenteras i denna rapport. En viktig slutsats är att arbetet med hållbarhetsanalyser måste komma in tidigt i avhjälpandeprocessen, redan i inledningen av huvudstudien, och hållbarhetsaspekterna bör återspeglas i de övergripande åtgärdsmål som formuleras. Som exempel måste de övergripande åtgärdsmålen lägga en grund för återfyllnadsmassornas kvalitet vid schaktsaneringar, så att en fungerande markmiljö återskapas. En annan slutsats är att det krävs ett iterativt arbetssätt för att en hållbarhetsanalys ska bli framgångsrik. Det innebär att det kan vara nödvändigt att backa till tidigare moment för att modifiera åtgärdsalternativ och samla in kompletterande information. Utgångspunkten i arbetet ska vara att den riskreduktion som krävs ska uppnås på ett så hållbart sätt som möjligt. Det gäller att vara observant på att samtliga efterbehandlingsalternativ verkligen uppfyller kravet på riskreduktion. För flera moment i huvudstudien behöver vägledningar tas fram, med fokus på hållbarhet. Detta gäller bland annat hur övergripande åtgärdsmål formuleras och hur en åtgärdsutredning bör utformas. Tydligare vägledning i dessa och liknande frågor kan i förlängningen bidra till mer hållbara efterbehandlingsåtgärder.
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| 2. |
- Backman, Sofia, et al.
(författare)
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Reduced EEG montage has a high accuracy in the post cardiac arrest setting
- 2020
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Ingår i: Clinical Neurophysiology. - : Elsevier BV. - 1388-2457. ; 131:9, s. 2216-2223
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To study if comatose cardiac arrest patients can be assessed with a reduced number of EEG electrodes. Methods: 110 routine EEGs from 67 consecutive patients, including both hypothermic and normothermic EEGs were retrospectively assessed by three blinded EEG-experts using two different electrode montages. A standard 19-electrode-montage was compared to the reduced version of the same EEGs, down-sampled to six electrodes (F3, T3, P3, F4, T4, P4). We used intra-rater and inter-observer statistics to assess the reliability of the reduced montage for background features and discharges. Results: The reduced montage had almost perfect performance for background continuity (κ 0.80–0.88), including identification of highly malignant backgrounds (burst-suppression/suppression) (κ 0.85–0.94) and benign backgrounds (continuous/nearly continuous) (κ 0.85–0.91). We found substantial performance for identifying rhythmic/periodic discharges (κ 0.79–0.86). The reduced montage had high accuracy for assessment of both highly malignant (sensitivity 91–95%, specificity 94–99%) and benign (sensitivity 89–98%, specificity 91–96%) backgrounds, and periodic/rhythmic patterns (sensitivity 79–100%, specificity 89–99%), compared to the full montage. The inter-observer variability was not increased by the reduced montage. Conclusion: Reduced EEG had high performance for classifying important background and discharge patterns in this post cardiac arrest cohort. Significance: Our results support the use of reduced EEG-montage for monitoring comatose cardiac arrest patients.
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| 3. |
- Billing, Erik, PhD, 1981-, et al.
(författare)
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Language Models for Human-Robot Interaction
- 2023
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Ingår i: HRI '23. - New York, NY, USA : ACM Digital Library. - 9781450399708 ; , s. 905-906
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Konferensbidrag (refereegranskat)abstract
- Recent advances in large scale language models have significantly changed the landscape of automatic dialogue systems and chatbots. We believe that these models also have a great potential for changing the way we interact with robots. Here, we present the first integration of the OpenAI GPT-3 language model for the Aldebaran Pepper and Nao robots. The present work transforms the text-based API of GPT-3 into an open verbal dialogue with the robots. The system will be presented live during the HRI2023 conference and the source code of this integration is shared with the hope that it will serve the community in designing and evaluating new dialogue systems for robots.
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| 4. |
- Blom, Kerstin, et al.
(författare)
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An investigation and replication of sleep-related cognitions, acceptance and behaviours as predictors of short- and long-term outcome in cognitive behavioural therapy for insomnia
- 2021
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Ingår i: Journal of Sleep Research. - : John Wiley & Sons. - 0962-1105 .- 1365-2869. ; 30:5
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Tidskriftsartikel (refereegranskat)abstract
- The objectives were to investigate the potential for sleep-related behaviours, acceptance and cognitions to predict outcome (insomnia severity) of cognitive behavioural therapy for insomnia (CBT-I). Baseline and outcome data from four randomised controlled trials (n = 276) were used. Predictors were the Dysfunctional Beliefs and Attitudes about Sleep-10 (DBAS-10), Sleep-Related Behaviours Questionnaire (SRBQ), and Sleep Problems Acceptance Questionnaire (SPAQ), and empirically derived factors from a factor analysis combining all items at baseline (n = 835). Baseline values were used to predict post-treatment outcome, and pre-post changes in the predictors were used to predict follow-up outcomes after 3-6 months, 1 year, or 3-10 years, measured both as insomnia severity and as better or worse long-term sleep patterns. A majority (29 of 52) of predictions of insomnia severity were significant, but when controlling for insomnia severity, only two (DBAS-10 at short-term and SRBQ at mid-term follow-up) of the 12 predictions using established scales, and three of the 40 predictions using empirically derived factors, remained significant. The strongest predictor of a long-term, stable sleep pattern was insomnia severity reduction during treatment. Using all available predictors in an overfitted model, 21.2% of short- and 58.9% of long-term outcomes could be predicted. We conclude that although the explored constructs may have important roles in CBT-I, the present study does not support that the DBAS-10, SRBQ, SPAQ, or factors derived from them, would be unique predictors of outcome.
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| 5. |
- Charlton, Jennifer R., et al.
(författare)
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Beyond the tubule : pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease
- 2020
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Ingår i: American Journal of Physiology - Renal Physiology. - : AMER PHYSIOLOGICAL SOC. - 1931-857X .- 1522-1466. ; 319:6, s. F988-F999
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Tidskriftsartikel (refereegranskat)abstract
- Pathogenic variants in the LRP2 gene, encoding the multiligand receptor megalin, cause a rare autosomal recessive syndrome: Donnai-Barrow/Facio-Oculo-Acoustico-Renal (DB/FOAR) syndrome. Because of the rarity of the syndrome, the long-term consequences of the tubulopathy on human renal health have been difficult to ascertain, and the human clinical condition has hitherto been characterized as a benign tubular condition with asymptomatic low-molecularweight proteinuria. We investigated renal function and morphology in a murine model of DB/FOAR syndrome and in patients with DB/FOAR. We analyzed glomerular filtration rate in mice by FETC-inulin clearance and clinically characterized six families, including nine patients with DB/FOAR and nine family members. Urine samples from patients were analyzed by Western blot analysis and biopsy materials were analyzed by histology. In the mouse model, we used histological methods to assess nephrogenesis and postnatal renal structure and contrast-enhanced magnetic resonance imaging to assess glomerular number. In megalin-deficient mice, we found a lower glomerular filtration rate and an increase in the abundance of injury markers, such as kidney injury molecule-1 and N-acetyl-11-n-glucosaminidase. Renal injury was validated in patients, who presented with increased urinary kidney injury molecule-1, classical markers of chronic kidney disease, and glomerular proteinuria early in life. Megalin-deficient mice had normal nephrogenesis, but they had 19% fewer nephrons in early adulthood and an increased fraction of nephrons with disconnected glomerulotubular junction. In conclusion, megalin dysfunction, as present in DB/FOAR syndrome, confers an increased risk of progression into chronic kidney disease.
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| 6. |
- Gyldenkerne, Christine, et al.
(författare)
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Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients : PROSPECT II
- 2023
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Ingår i: Circulation. - : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 147:6, s. 469-481
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content.METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segment elevation underwent 3-vessel quantitative coronary angiography and coregistered near-infrared spectroscopy and intravascular ultrasound imaging after successful percutaneous coronary intervention. Subsequent MACEs were adjudicated to either treated culprit lesions or untreated nonculprit lesions. This substudy stratified patients by diabetes status and assessed baseline culprit and nonculprit prevalence of high-risk plaque characteristics defined as maximum plaque burden ≥70% and maximum lipid core burden index ≥324.7. Separate covariate-adjusted multivariable models were performed to identify whether diabetes was associated with nonculprit lesion-related MACEs and high-risk plaque characteristics.RESULTS: Diabetes was present in 109 of 898 patients (12.1%). During a median 3.7-year follow-up, MACEs occurred more frequently in patients with versus without diabetes (20.1% versus 13.5% [odds ratio (OR), 1.94 (95% CI, 1.14-3.30)]), primarily attributable to increased risk of myocardial infarction related to culprit lesion restenosis (4.3% versus 1.1% [OR, 3.78 (95% CI, 1.12-12.77)]) and nonculprit lesion-related spontaneous myocardial infarction (9.3% versus 3.8% [OR, 2.74 (95% CI, 1.25-6.04)]). However, baseline prevalence of high-risk plaque characteristics was similar for patients with versus without diabetes concerning culprit (maximum plaque burden ≥70%: 90% versus 93%, P=0.34; maximum lipid core burden index ≥324.7: 66% versus 70%, P=0.49) and nonculprit lesions (maximum plaque burden ≥70%: 23% versus 22%, P=0.37; maximum lipid core burden index ≥324.7: 26% versus 24%, P=0.47). In multivariable models, diabetes was associated with MACEs in nonculprit lesions (adjusted OR, 2.47 [95% CI, 1.21-5.04]) but not with prevalence of high-risk plaque characteristics (adjusted OR, 1.21 [95% CI, 0.86-1.69]).CONCLUSIONS: Among patients with recent myocardial infarction, both treated and untreated lesions contributed to the diabetes-associated ≈2-fold increased MACE rate during the 3.7-year follow-up. Diabetes-related plaque characteristics that might underlie this increased risk were not identified by multimodality imaging.
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| 7. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- 2022
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 79:3, s. 228-243
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Tidskriftsartikel (refereegranskat)abstract
- One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
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| 8. |
- Jernelöv, Susanna, et al.
(författare)
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Very long-term outcome of cognitive behavioral therapy for insomnia : one- and ten-year follow-up of a randomized controlled trial
- 2022
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Ingår i: Cognitive Behaviour Therapy. - : Taylor & Francis Group. - 1650-6073 .- 1651-2316. ; 51:1, s. 72-88
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Tidskriftsartikel (refereegranskat)abstract
- Insomnia is a common and chronic disorder, and cognitive behavioral therapy (CBT) is the recommended treatment. Very long-term follow-ups of CBT are very rare, and this study aimed to investigate if improvements were stable one and ten years after CBT for insomnia (CBT-i). Based on a three-armed randomized controlled trial of bibliotherapeutic CBT-i, participants received an insomnia-specific self-help book and were randomized to therapist guidance, no guidance, or a waitlist receiving unguided treatment after a delay. Six weeks of treatment was given to 133 participants diagnosed with insomnia disorder. After one and ten years, participants were assessed with self-reports and interviews. Improvements were statistically significant and well maintained at one- and ten-year follow-ups. Average Insomnia Severity Index score [95%CI] was 18.3 [17.7-18.8] at baseline, 10.1 [9.3-10.9] at post-treatment, 9.2 [8.4-10.0] at one- and 10.7 [9.6-11.8] at ten-year follow-up, and 64% and 66% of participants no longer fulfilled criteria for an insomnia diagnosis at one and ten years, respectively. Positive effects of CBT were still present after ten years. Insomnia severity remained low, and two-thirds of participants no longer fulfilled criteria for an insomnia diagnosis. This extends previous findings of CBT, further confirming it as the treatment of choice for insomnia.
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| 9. |
- Johansson, Erik, et al.
(författare)
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Coupling of lattice dynamics and configurational disorder in metal deficient Al1-delta B2 from first-principles
- 2021
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 130:1
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the role metal vacancies play in the phase stability and properties of Al1-delta B2 using first-principles calculations, alloy theory simulations, phonon calculations, and experimental in situ x-ray diffraction measurements of thermal expansion. The relevant concentrations and configurations of metal vacancies are analyzed using cluster expansion and special quasirandom structure methods combined with vibrational free energy calculations within the quasiharmonic approximation for ordered and disordered phases. We find that electronic structure effects stabilize Al1-delta B2 in a narrow composition range of 0.073 < delta < 0.096 depending only weakly on temperature while they destabilize ideal stoichiometric AlB2. This composition corresponds to the narrow range 0:311 <= x <= 0.317 in the formulation of AlxB1-x, which can explain the appearance of this phase as a line compound with the ideal AlB2 stoichiometry in most phase diagrams. The ordered structures of vacancies found at low temperature are destabilized and disordered already at a low temperature of similar to 200 K. Our experiments observe linear thermal expansion coefficients alpha(a) = 4.8 x 10(-6) K-1 and alpha(c) = 10.85 x 10(-6) K-1 at room temperature. Only thermal expansion calculations of disordered phases compare well with these measurements, and, in particular, stoichiometric vacancy-free AlB2 shows dramatic overestimations of the experimental thermal expansion. These results highlight the importance of disordered Al vacancies on both stability and vibrational properties of Al1-delta B2. (c) 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license
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| 10. |
- Johansson, Erik, et al.
(författare)
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The effect of strain and pressure on the electron-phonon coupling and superconductivity in MgB2-Benchmark of theoretical methodologies and outlook for nanostructure design
- 2022
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 131:6
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Tidskriftsartikel (refereegranskat)abstract
- Different theoretical methodologies are employed to investigate the effect of hydrostatic pressure and anisotropic stress and strain on the superconducting transition temperature ( T-c) of MgB2. This is done both by studying Kohn anomalies in the phonon dispersions alone and by explicit calculation of the electron-phonon coupling. It is found that increasing pressure suppresses T-c in all cases, whereas isotropic and anisotropic strain enhances the superconductivity. In contrast to trialed epitaxial growth that is limited in the amount of achievable lattice strain, we propose a different path by co-deposition with ternary diborides that thermodynamically avoid mixing with MgB2. This is suggested to promote columnar growth that can introduce strain in all directions.
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