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| 2. |
- Willer, Cristen J., et al.
(författare)
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 25-34
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Tidskriftsartikel (refereegranskat)abstract
- Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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| 3. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 4. |
- Casolino, M., et al.
(författare)
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Launch of the space experiment PAMELA
- 2008
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Ingår i: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948. ; 42:3, s. 455-466
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature in a wide energy range (protons 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50 MeV-270 GeV) and search for antimatter with a precision of the order of 10-8. The experiment, housed on board the Russian Resurs-DK I satellite, was launched on June 15th, 2006 in a 350 x 600 km orbit with all inclination of 70'. The detector is composed of a series of scintillator counters arranged at the extremities of a permanent magnet spectrometer to provide charge, time-of-flight, and rigidity information. Lepton/hadron identification is performed by a silicon-tungsten calorimeter and a neutron detector placed at the bottom of the device. An anticounter system is used offline to reject false triggers coming from the satellite. In self-trigger mode the calorimeter, the neutron detector, and a shower tail catcher are capable of an independent measure of the lepton component up to 2 TeV. In this work we describe the experiment, its scientific objectives, and the performance in the first months after launch.
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| 5. |
- Adriani, O., et al.
(författare)
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The PAMELA space mission
- 2008
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Ingår i: Astroparticle, Part. Space Phys., Detect. Med. Phys. Appl. - Proc. Conf.. - : WORLD SCIENTIFIC. - 9812819088 - 9789812819086 ; , s. 858-864
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Konferensbidrag (refereegranskat)abstract
- The PAMELA (a Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics) experiment, is a satellite-borne particle spectrometer. It was launched on 15th June 2006 from the Baikonur cosmodrome in Kazakhstan, is installed into the Russian Resurs-DK1 satellite. PAMELA is composed of a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. Among the PAMELA major objectives are the study of charged particles in the cosmic radiation, the investigation of the nature of dark matter, by mean of the measure of the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved. PAMELA has been in a nearly continuous data taking mode since llth July 2006. The status of the apparatus and performances will be presented.
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| 6. |
- Boezio, M., et al.
(författare)
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The first year in orbit of the pamela experiment
- 2007
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Ingår i: Proceedings of the 30th International Cosmic Ray Conference, ICRC 2007. - : Universidad Nacional Autonoma de Mexico. ; , s. 99-102
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Konferensbidrag (refereegranskat)abstract
- On the 15th of June 2006, the PAMELA experiment mounted on the Resurs DK1 satellite, was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. PAMELA is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, to investigate the nature of dark matter, measuring the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved, and to search for antinuclei with unprecedented sensitivity. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. We will present the status of the apparatus after one year in orbit. Furthermore, we will discuss the PAMELA in-flight performances.
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| 7. |
- Boezio, M., et al.
(författare)
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The PAMELA space experiment : First year of operation
- 2008
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Ingår i: Journal of Physics, Conference Series. - : Institute of Physics Publishing (IOPP). - 1742-6588 .- 1742-6596. ; 110:6
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Tidskriftsartikel (refereegranskat)abstract
- On the 15th of June 2006 the PAMELA experiment, mounted on the Resurs DK1 satellite, was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. PAMELA is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, to investigate the nature of dark matter, measuring the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved, and to search for antinuclei with unprecedented sensitivity. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows charged particle identification over a wide energy range. © 2008 IOP Publishing Ltd.
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| 8. |
- Casolino, M., et al.
(författare)
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Magnetospheric and solar physics observations with the PAMELA experiment
- 2008
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 588:1-2, s. 243-246
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satellite-borne experiment designed to make long duration measurements of the cosmic radiation in Low Earth Orbit. It is devoted to the detection of the cosmic-ray spectra in the 100 MeV-300 GeV range with primary scientific goal the measurement of antiproton and positron spectra over the largest energy range ever achieved. Other tasks include the search for antinuclei with unprecedented sensitivity and the measurement of the light nuclear component of cosmic rays. In addition, PAMELA can investigate phenomena connected with solar and Earth physics. The apparatus consists of: a Time of Flight system, a magnetic spectrometer, an electromagnetic imaging calorimeter, a shower tail catcher scintillator, a neutron detector and an anticoincidence system. In this work we present some measurements of galactic, secondary and trapped particles performed in the first months of operation.
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| 9. |
- Galper, A. M., et al.
(författare)
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International Russian-Italian mission "Rim-Pamela
- 2009
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Ingår i: Proceedings of the 13th Lomonosov Conference on Elementary Particle Physics. - : WORLD SCIENTIFIC. - 9812837582 - 9789812837585 ; , s. 199-206
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Konferensbidrag (refereegranskat)abstract
- The successful launch of spacecraft "RESURS DK" 1 with precision magnetic spectrometer "PAMELA" onboard was executed at Baikonur cosmodrome 15 June 2006. The primary phase of realization of International Russian-Italian Project "RIM-PAMELA" with German and Swedish scientists' participation has begun since the launch of instrument "PAMELA" that has mainly been directed to investigate the fluxes of galactic cosmic rays. This report contains the main scientific Project's tasks and the conditions of science program's implementation after one year since exploration has commenced.
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| 10. |
- Pearce, Mark, et al.
(författare)
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PAMELA : a payload for antimatter matter exploration and light-nuclei astrophysics - status and first results
- 2007
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Ingår i: 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11. - 9781424409228 ; , s. 42-47
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Konferensbidrag (refereegranskat)abstract
- PAMELA is a satellite-borne experiment designed for precision studies of the charged cosmic radiation. The primary scientific goal is the study of the antimatter component of the cosmic radiation (antiprotons, 80 MeV - 190 GeV; and positrons, 50 MeV - 270 GeV) in order to search for evidence of dark matter particle annihilations. PAMELA will also search for primordial antinuclei (in particular, anti-helium), and test cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and studies of light nuclei and their isotopes. Concomitant goals include a study of solar physics and solar modulation during the 24th solar minimum by investigating low energy particles in the cosmic radiation; and a reconstruction of the cosmic ray electron energy spectrum up to several TeV thereby allowing a possible contribution from local sources to be studied. PAMELA is housed on-board the Russian Resurs-DK1 satellite, which was launched on June 15th 2006 in an elliptical (350-600 km altitude) orbit with an inclination of 70 degrees. PAMELA consists of a permanent magnet spectrometer, to provide rigidity and charge sign information; a Time-of-Flight and trigger system, for velocity and charge determination; a silicon-tungsten calorimeter, for lepton/hadron discrimination; and a neutron detector. An anticoincidence system is used offline to reject false triggers. In this article the PAMELA experiment and its status are reviewed. A preliminary discussion of data recorded in-orbit is also presented.
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