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- Govind, Satish C., et al.
(författare)
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Differing myocardial response to a single session of hemodialysis in end-stage renal disease with and without type 2 diabetes mellitus and coronary artery disease
- 2006
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Ingår i: Cardiovascular Ultrasound. - : Springer Science and Business Media LLC. - 1476-7120. ; 4:9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Though hemodialysis (HD) acutely improves cardiac function, the impact of background diseases like coronary artery disease (CAD) and Type 2 diabetes (DM) in the setting of end-stage renal disease (ESRD) is not known. Tissue velocity echocardiography (TVE) offers a fast choice to follow changes in myocardial function after HD in ESRD with concomitant DM and/or CAD. Methods: 46 subjects (17 with ESRD, Group 1; 15 with DM, Group 2; 14 with DM+CAD, Group 3) underwent standard and TVE prior to and shortly after HD. Besides standard Doppler variables, regional myocardial systolic and diastolic velocities, as well as systolic strain rate were post processed. Results: Compared with pre-HD, post-HD body weight (kg) significantly decreased in all the three groups (51 ± 9 vs. 48 ± 8, 62 ± 10 vs.59 ± 10, and 61 ± 9 vs. 58 ± 9 respectively; all p < 0.01). Left ventricular end diastolic dimensions (mm) also decreased post- HD (46 ± 5 vs. 42 ± 7, 53 ± 7 vs. 50 ± 7, 51 ± 7 vs. 47 ± 8 respectively; all p < 0.01). Regional longitudinal peak systolic velocity in septum (cm/s) significantly increased post-HD in Group 1(5.7 ± 1.6 vs. 7.2 ± 2.3; p < 0.001) while remained unchanged in the other two groups. Similar trends were noted in other left ventricular walls. When the myocardial velocities (cm/s) were computed globally, the improvement was seen only in Group 1 (6.3 ± 1.5 vs. 7.9 ± 2.0; p < 0.001). Global early regional diastolic velocity (cm/s) improved in Group 1, remained unchanged in Group 2, while significantly decreased in Group 3(-5.9 ± 1.3 vs. -4.1 ± 1.8; p < 0.01). Global systolic strain rate (1/sec) increased in the first 2 Groups but remained unchanged (-0.87 ± 0.4 vs. -0.94 ± 0.3; p = ns) in Group 3. Conclusion: A single HD session improves LV function only in ESRD without coexistent DM and/or CAD. The present data suggest that not only dialysis-dependent changes in loading conditions but also co-existent background diseases determine the myocardial response to HD.
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| 2. |
- Lind, Britta, et al.
(författare)
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Longitudinal isovolumic displacement of the left ventricular myocardium assessed by tissue velocity echocardiography in healthy individuals
- 2006
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Ingår i: Journal of the American Society of Echocardiography. - : Elsevier BV. - 0894-7317 .- 1097-6795. ; 19:3, s. 255-265
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Tidskriftsartikel (refereegranskat)abstract
- Rapid myocardial isovolumic motions are reportedly involved in the left ventricular reshaping process and may contribute to total systolic myocardial shortening. in this study, the qualitative and quantitative analysis of longitudinal myocardial isovolumic displacement was performed in 49 healthy individuals (23 men and 26 women) in age groups 21 to 49 and 50 to 76 years using tissue velocity echocardiography. The obtained isovolumic contraction and relaxation displacement curves were biphasic and displayed a significant regional heterogeneity most probably reflecting active presystolic and post-systolic reshaping of left ventricular cavity. Besides some sex difference in younger individuals, there was an age-dependent lengthening of the isovolumic relaxation time and their motion components. Even if being of short duration, the longitudinal myocardial isovolumic displacement may accounted for as much as 14% of the total longitudinal myocardial shortening, a fact which should be taken into consideration when assessing left ventricular systolic function.
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