| 1. |
- Holloway-Attaway, Lissa, et al.
(författare)
-
Designing Postdigital Curators : Establishing an Interdisciplinary Games and Mixed Reality Cultural Heritage Network
- 2018
-
Ingår i: Advances in Digital Cultural Heritage. - Cham : Springer-Verlag New York. - 9783319757889 - 9783319757896 ; , s. 162-173
-
Bokkapitel (refereegranskat)abstract
- As digital technologies have become more integrated in museum and cultural heritage contexts over the past decade, digital museums enter a new phase of coming into their own. This opens up opportunities for the incorporation of cutting-edge multiplayer gaming technologies and immersive mixed reality (MR) systems. To support nuanced and original engagement with the newly pervasive nature of the digital in museums, an interdisciplinary group of international researchers, designers, and museum professionals have established a new network: the Designing Digital Heritage Network (DDHN). The network operates to support research, design production, interdisciplinary collaboration, and the development of innovative new pedagogies and programs to ‘design’ the postdigital curators of the future. This paper outlines the mission and vision of the DDHN, and suggests initial directions for future research in the postdigital heritage field focused on interdisciplinary, performative, and game design approaches to production and exhibition. © 2018, Springer International Publishing AG, part of Springer Nature.
|
|
| 2. |
- Rouse, Rebecca, et al.
(författare)
-
Re-Engineering Computational Curricula with Postdigital Heritage, Critical Humanities, and Community Engagement
- 2018
-
Ingår i: Proceedings of the2018 3rd Digital Heritage International Congress (DigitalHERITAGE) held jointly with the 2018 24th International Conference on Virtual Systems & Multimedia (VSMM 2018). - : IEEE. - 9781728102931 - 9781728102924
-
Konferensbidrag (refereegranskat)abstract
- The field of Digital Heritage is ideal for re-engineering computational curricula by integrating critical humanities and community engagement approaches with computer science practices to address the deep entanglement of digital technologies and culture in tension today. This paper will present a series of brief case studies to share lessons learned from the development of Digital Heritage curriculum design. In analyzing these case studies, we identify a set of best practices in Digital Heritage curricular design.
|
|
| 3. |
- Tordo, Julie, et al.
(författare)
-
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
- 2018
-
Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 141:7, s. 2014-2031
-
Tidskriftsartikel (refereegranskat)abstract
- Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are low transduction rates and inefficient distribution of the vector. To overcome these hurdles, a variety of capsid engineering methods have been utilized to generate capsids with improved transduction properties. Here we describe an alternative approach to capsid engineering, which draws on the natural evolution of the virus and aims to yield capsids that are better suited to infect human tissues. We generated an AAV capsid to include amino acids that are conserved among natural AAV2 isolates and tested its biodistribution properties in mice and rats. Intriguingly, this novel variant, AAV-TT, demonstrates strong neurotropism in rodents and displays significantly improved distribution throughout the central nervous system as compared to AAV2. Additionally, sub-retinal injections in mice revealed markedly enhanced transduction of photoreceptor cells when compared to AAV2. Importantly, AAV-TT exceeds the distribution abilities of benchmark neurotropic serotypes AAV9 and AAVrh10 in the central nervous system of mice, and is the only virus, when administered at low dose, that is able to correct the neurological phenotype in a mouse model of mucopolysaccharidosis IIIC, a transmembrane enzyme lysosomal storage disease, which requires delivery to every cell for biochemical correction. These data represent unprecedented correction of a lysosomal transmembrane enzyme deficiency in mice and suggest that AAV-TT-based gene therapies may be suitable for treatment of human neurological diseases such as mucopolysaccharidosis IIIC, which is characterized by global neuropathology.
|
|
