| 1. |
- Pfaller, M.A., et al.
(författare)
-
Twelve years of fluconazole in clinical practice : Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
- 2004
-
Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 10:SUPPL. 1, s. 11-23
-
Tidskriftsartikel (refereegranskat)abstract
- We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
|
|
| 2. |
- Stanoiu, M., et al.
(författare)
-
Study of neutron rich carbon and oxygen nuclei up to drip line
- 2004
-
Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474 .- 1873-1554. ; 746, s. 135C-139C
-
Tidskriftsartikel (refereegranskat)abstract
- In-beam gamma-spectroscopy using fragmentation reactions of radioactive beams have been performed in order to study the structure of excited states in neutron rich oxygen and carbon isotopes. For the produced fragments, gamma-ray energies, intensities and gamma-gamma coincidences have been measured. The experiment was performed at GANIL. New gamma-lines have been identified and placed in level schemes for C17-20. The non observation of any gamma-ray in O-23,O-24 suggests that their first excited states lie above the neutron threshold. These results are discussed in the framework of shell model calculations.
|
|
| 3. |
- Stanoiu, M., et al.
(författare)
-
Study of drip line nuclei through two-step fragmentation
- 2004
-
Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 20:1, s. 95-96
-
Tidskriftsartikel (refereegranskat)abstract
- We have studied the structure of light neutron-rich nuclei around N = 16 by employing the in-beam gamma-ray spectroscopy technique using the fragmentation of secondary beams of Ne-25,Ne-26, Na-27,Na-28 and Mg-29,Mg-30 isotopes. This secondary-beam cocktail was obtained by the fragmentation of a 36 S beam at 77.5 MeV.A by the SISSI/GANIL facility. By a second-step fragmentation, we have measured gamma-ray-residue coincidences in C17-20 and O-23,O-24 and described the obtained levels in the framework of the shell model.
|
|
| 4. |
|
|
| 5. |
|
|
