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Clinical spectrum o...
Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study
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- Majidi, Fatemeh (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Martino, Samuela (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Kondakci, Mustafa (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Antke, Christina (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Haase, Matthias (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Chortis, Vasileios (author)
- Birmingham Hlth Partners, England; Univ Birmingham, England
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- Arlt, Wiebke (author)
- Birmingham Hlth Partners, England; Univ Birmingham, England
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- Ronchi, Cristina L. (author)
- Univ Birmingham, England; Univ Wurzburg, Germany
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- Fassnacht, Martin (author)
- Univ Wurzburg, Germany
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- Laurent, Claire (author)
- Univ Hosp Dijon, France
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- Petit, Jean-Michel (author)
- Univ Hosp Dijon, France
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- Casasnovas, Olivier (author)
- Univ Hosp Djion, France
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- Habra, Amir Mouhammed (author)
- Univ Texas MD Anderson Canc Ctr, TX 77030 USA
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- Kanji, Aleem (author)
- Baylor Coll Med, TX 77030 USA
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- Salvatori, Roberto (author)
- Johns Hopkins Univ, MD USA
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- Nhat Ho, An Thi (author)
- Medstar Harbor Hosp, MD USA
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- Spyroglou, Ariadni (author)
- Univ Spital Zurich, Switzerland
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- Beuschlein, Felix (author)
- Univ Spital Zurich, Switzerland; Ludweig Maximilians Univ Munchen, Germany
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- Villa, Diego (author)
- BC Canc Ctr Lymphoid Canc, Canada; Univ British Columbia, Canada
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- Limvorapitak, Wasithep (author)
- BC Canc Ctr Lymphoid Canc, Canada; Univ British Columbia, Canada; Thammasat Univ, Thailand
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- Wahlin, Bjoern Engelbrekt (author)
- Karolinska Institutet
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- Gimm, Oliver (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Rudelius, Martina (author)
- Ludweig Maximilians Univ Munchen, Germany
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- Schott, Matthias (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Germing, Ulrich (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Haas, Rainer (author)
- Heinrich Heine Univ Dusseldorf, Germany
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- Gattermann, Norbert (author)
- Heinrich Heine Univ Dusseldorf, Germany
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(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2020
- 2020
- English.
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In: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 183:4, s. 453-462
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency. Methods: Ninety-seven patients from 14 centers in Europe, Canada and the United States were included in this retrospective analysis between 1994 and 2017. Results: Of the 81 patients with imaging data, 19 (23%) had isolated adrenal involvement (iPAL), while 62 (77%) had additional extra-adrenal involvement (PAL+). Among patients who had both CT and PET scans, 18FDG-PET revealed extra-adrenal involvement not detected by CT scan in 9/18 cases (50%). The most common clinical manifestations were B symptoms (55%), fatigue (45%), and abdominal pain (35%). Endocrinological assessment was often inadequate. With a median follow-up of 41.6 months, 3-year progression-free (PFS) and overall (OS) survival rates in the entire cohort were 35.5% and 39.4%, respectively. The hazard ratios of iPAL for PFS and OS were 40.1 (95% CI: 2.63-613.7, P = 0.008) and 2.69 (95% CI: 0.61-11.89, P = 0.191), respectively. PFS was much shorter in iPAL vs PAL+ (median 4 months vs not reached, P = 0.006), and OS also appeared to be shorter (median 16 months vs not reached), but the difference did not reach statistical significance (P = 0.16). Isolated PAL was more frequent in females (OR = 3.81; P = 0.01) and less frequently associated with B symptoms (OR = 0.159; P = 0.004). Conclusion: We found unexpected heterogeneity in the clinical spectrum of PAL. Further studies are needed to clarify whether clinical distinction between iPAL and PAL+ is corroborated by differences in molecular biology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Majidi, Fatemeh
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Martino, Samuela
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Kondakci, Mustaf ...
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Antke, Christina
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Haase, Matthias
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Chortis, Vasilei ...
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show more...
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Arlt, Wiebke
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Ronchi, Cristina ...
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Fassnacht, Marti ...
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Laurent, Claire
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Petit, Jean-Mich ...
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Casasnovas, Oliv ...
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Habra, Amir Mouh ...
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Kanji, Aleem
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Salvatori, Rober ...
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Nhat Ho, An Thi
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Spyroglou, Ariad ...
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Beuschlein, Feli ...
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Villa, Diego
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Limvorapitak, Wa ...
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Wahlin, Bjoern E ...
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Gimm, Oliver
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Rudelius, Martin ...
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Schott, Matthias
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Germing, Ulrich
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Haas, Rainer
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Gattermann, Norb ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Karolinska Institutet