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Träfflista för sökning "WFRF:(Rudenstam Carl Magnus 1930) srt2:(1994)"

Sökning: WFRF:(Rudenstam Carl Magnus 1930) > (1994)

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Numrering	Referens	Omslagsbild	Hitta
1.	Hellstrand, Kristoffer, 1956, et al. (författare) Histamine in immunotherapy of advanced melanoma: a pilot study. 1994 Ingår i: Cancer immunology, immunotherapy : CII. - 0340-7004. ; 39:6, s. 416-9 Tidskriftsartikel (refereegranskat)abstract Sixteen patients with advanced metastatic malignant melanoma were treated with a high-dose infusion of interleukin-2 (IL-2; 18 x 10(6) IU/m-2 day-1) together with daily subcutaneous (s.c.) injections of interferon alpha (IFN alpha; 3 x 10(6) U/m-2 day-1) in 5-day cycles. Nine of these patients were given histamine (1 mg s.c.) twice daily during treatment with IL-2 and IFN alpha. In the seven patients who did not receive histamine, one partial response (that is a reduction of more than 50% in the total tumour burden) was observed in a patient with skin and lymph node melanoma. In the eight histamine-treated patients evaluable for response, four partial responses were observed. Two other patients showed regression at one site of metastasis but tumours remained unchanged at other sites. Two histamine-treated patients showed complete resolution of extensive liver metastasis. Sites of response in histamine-treated patients also included the subcutis, lymph nodes, skeleton, spleen and muscle. Lung melanoma did not respond to histamine/IL-2/IFN alpha. Three patients with lung tumours responded with significant (more than 50%) reduction of the volume of soft-tissue tumours, suggesting that the response to histamine may be organotropic. Survival was significantly prolonged in patients receiving histamine. Our data suggest that treatment with histamine may improve the antitumour efficacy of immunotherapy in metastatic melanoma.
2.	Naredi, Peter, 1955, et al. (författare) Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha. 1994 Ingår i: The European journal of surgery = Acta chirurgica. - 1102-4151. ; 160:2, s. 67-75 Tidskriftsartikel (refereegranskat)abstract To correlate changes in whole body resting energy expenditure and protein breakdown with the production of stress hormones, excretion of polyamines, and circulating concentrations of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in patients undergoing treatment with high doses of interleukin-2 (IL-2) and interferon-alpha (IFN-alpha).

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Naredi, Peter, 1955 (2); Lundholm, Kent, 1945 (2); Rudenstam, Carl-Magn ... (2); Hafström, Lars-Olof, ... (2); Hellstrand, Kristoff ... (1); Asztely, Mats (1); visa fler...; Lindner, Per, 1956 (1); Hermodsson, Svante, ... (1); Zachrisson, H (1); visa färre...

Lärosäte: Göteborgs universitet (2)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År: 1994 (2)Ta bort avgränsningen

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