| 1. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 2. |
- Goswami, Aruna, et al.
(författare)
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A high-resolution spectral analysis of three carbon-enhanced metal-poor stars
- 2006
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 372:1, s. 343-356
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Tidskriftsartikel (refereegranskat)abstract
- We present results of an analysis of high-resolution spectra (R similar to 50 000), obtained with the Subaru Telescope High Dispersion Spectrograph, of two carbon-enhanced metal-poor (CEMP) stars selected from the Hamburg/European Southern Observatory prism survey, HE 1305+0007 and HE 1152-0355, and of the classical CH star HD 5223. All these stars have relatively low effective temperatures (4000-4750 K) and high carbon abundances, which result in the presence of very strong molecular carbon bands in their spectra. The stellar atmospheric parameters for these stars indicate that they all have surface gravities consistent with a present location on the red giant branch, and metallicities of [Fe/H] = -2.0 (HE 1305+0007, HD 5223) and [Fe/H] = -1.3 (HE 1152-0355). In addition to their large enhancements of carbon ([C/Fe] = +1.8, +1.6, and +0.6, respectively), all three stars exhibit strong enhancements of the s-process elements relative to iron. HE 1305+0007 exhibits a large enhancement of the third-peak s-process element, lead, with [Pb/Fe] = +2.37, as well as a high abundance of the r-process element europium, [Eu/Fe] = +1.97. The second-peak s-process elements, Ba, La, Ce, Nd and Sm, are found to be more enhanced than the first-peak s-process elements Zr, Sr and Y. Thus, HE 1305+0007 joins the growing class of the so-called 'Lead stars', and also the class of objects that exhibit the presence of both r- and s-process elements, the CEMP-r/s stars. The large enhancements of neutron-capture (n-capture) elements exhibited by HE 1152-0355 and HD 5223 are more consistent with the abundance patterns generally noticed in CH stars, essentially arising from pure s-process nucleosynthesis. The elemental abundance distributions observed in these stars are discussed in light of existing theories of CH star formation, as well as the suggested formation scenarios of the CEMP-r/s group.
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| 3. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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