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- Berger, Karoline, 1991, et al.
(författare)
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Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer
- 2021
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranulin, via its receptor sortilin, drives breast cancer stem cell propagation in vitro and increases metastasis formation in an in vivo breast cancer xenograft model. In this retrospective biomarker analysis, we aimed to determine whether tumor co-expression of progranulin and sortilin has prognostic and treatment predictive values for breast cancer patients. Methods We explored how co-expression of progranulin and sortilin was associated with established clinical markers by analyzing a tissue microarray including 560 randomized premenopausal breast cancer patients receiving either 2 years of tamoxifen treatment or no adjuvant treatment, with a median follow-up time of 28 years. Breast cancer-specific survival was analyzed using Kaplan-Meier and Cox Proportional Hazards regression models to assess the prognostic and predictive value of progranulin and sortilin in relation to known clinical markers. Results Co-expression of progranulin and sortilin was observed in 20% of the breast cancer samples. In untreated patients, prognostic considerations could be detailed separately from treatment prediction and the high progranulin and sortilin expressing subgroup was significantly associated with breast cancer-specific death in multivariable analyses (HR=2.188, CI: 1.317-3.637, p=0.003) along with tumor size, high tumor grade and lymph node positivity. When comparing the untreated patients with tamoxifen treated patients in the ER alpha positive subgroup, co-expression of progranulin and sortilin was not linked to tamoxifen resistance. Conclusion Data suggest that co-expression of progranulin and its receptor sortilin is a novel prognostic biomarker combination identifying a highly malignant subgroup of breast cancer. Importantly, this subpopulation could potentially be targeted with anti-sortilin based therapies.
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| 3. |
- Jansson, Måns, Filosofie doktor, 1986-, et al.
(författare)
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Improving Swedish Steelmaking : Circulation and Localized Knowledge-Making in Early Modernity
- 2023
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Ingår i: Technology and culture. - : Johns Hopkins University Press. - 0040-165X .- 1097-3729. ; 64:2, s. 515-542
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the multicentered processes that transformed artisanal metalworking in early modern Europe. It does so through an in-depth analysis of the attempts to improve steelmaking in eighteenth-century Sweden. Scholarship has traditionally focused on progress in the British steel industry, but the quest for improvement in Sweden's expanding steel sector, integrating various forms of cross-border mobility, illustrates a more spatially and temporally diverse history of technological development. This case study underlines the need to consider a wider group of actors and practices in metallurgical advances and elucidates the interaction between statecraft, scientific inquiry, and artisanal work, thereby highlighting the work-related foundations for novel perceptions of economic and industrial progress.
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| 5. |
- Jansson, Måns, Filosofie doktor, 1986-, et al.
(författare)
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The œconomia of iron and steel : Material transformations, manual skills, and technical improvement in early modern Sweden
- 2023
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Ingår i: The knowledge economy. - Florens : Firenze University Press. - 9791221500912 - 9791221500929 ; , s. 237-262
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Bokkapitel (refereegranskat)abstract
- Sweden was a major exporter of iron during the early-modern period, but there was also an important domestic steelmaking. We analyse the Swedish iron and steel trade in a long perspective in a European context. Our approach departs from recent discussions on industrial and scientific developments, in which the spheres of “Hand” and “Mind” are brought together, and where artisanal skills and natural resources are highlighted. We emphasise how the migration of people, and movements of materials and knowledge, influenced a process of gradual change. A key feature was the ongoing interactions between working people and educated savants. Our conclusion points to the perseverance of artisanal skills well into the nineteenth century, but also towards new links between work, technology, and markets.
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| 6. |
- Larsson, Liss Elin, et al.
(författare)
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Association of sarcopenia and its defining components with the degree of cognitive impairment in a memory clinic population
- 2023
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 96:2, s. 777-788
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sarcopenia and cognitive impairment are two leading causes of disabilities.Objective: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.Methods:368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer’s disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0–3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.Results: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06–0.90) and AD (OR: 0.12, 95% CI: 0.03–0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45–11.92).Conclusion: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.
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| 7. |
- Rydén, Göran, 1959-
(författare)
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Afterword
- 2020
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Ingår i: Globalized Peripheries<em></em>. - Woodbridge : Boydell & Brewer. - 9781783274758
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Rydén, Göran, 1959-
(författare)
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Making iron, producing space! How coerced work defined a Swedish early modern ironmaking region
- 2023
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Ingår i: Labor history. - : Taylor & Francis Group. - 0023-656X .- 1469-9702. ; 64:6, s. 706-719
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Tidskriftsartikel (refereegranskat)abstract
- Swedish ironmaking took place in mines, forests and rationally structured ironmaking communities (bruk), merging different forms of labour and coercion, wage labour, household labour and corvée labour often in the form of transport duties, as well as leases paid in kind. The aim is to analyse this diverse structure from an angle of motion, movement and mobility, and see how subordinated ironmaking artisanal and peasant households set the limits for the regions in which they were living while undertaking that work. It is essential to link this work to the owners’ ambition to control production, the workers and the tasks they were set to do. It meant to supervise production at the workshops, but more importantly, it meant to monitor the movement of raw material, grain and commodities, between these sites and markets outside the region. I use an extensive accounting material from one region to unravel patterns of work, and the owners’ ambitions to keep track of subordinated artisans and peasants. These patterns of work and supervision were, together with legal structures, a crucial element in the making of the spatial structuring of Swedish ironmaking.
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