| 1. |
- Hellström, Ulrika, 2000, et al.
(författare)
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Carbohydrates act as receptors for the periodontitis-associated bacterium Porphyromonas gingivalis: a study of bacterial binding to glycolipids.
- 2004
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Ingår i: Glycobiology. - : Oxford University Press (OUP). - 0959-6658 .- 1460-2423. ; 14:6, s. 511-9
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Tidskriftsartikel (refereegranskat)abstract
- In this study we show for the first time the use of carbohydrate chains on glycolipids as receptors for the periodontitis-associated bacterium Porphyromonas gingivalis. Previous studies have shown that this bacterium has the ability to adhere to and invade the epithelial lining of the dental pocket. Which receptor(s) the adhesin of P. gingivalis exploit in the adhesion to epithelial cells has not been shown. Therefore, the binding preferences of this specific bacterium to structures of carbohydrate origin from more than 120 different acid and nonacid glycolipid fractions were studied. The bacteria were labeled externally with (35)S and used in a chromatogram binding assay. To enable detection of carbohydrate receptor structures for P. gingivalis, the bacterium was exposed to a large number of purified total glycolipid fractions from a variety of organs from different species and different histo-blood groups. P. gingivalis showed a preference for fractions of human and pig origin for adhesion. Both nonacid and acid glycolipids were used by the bacterium, and a preference for shorter sugar chains was noticed. Bacterial binding to human acid glycolipid fractions was mainly obtained in the region of the chromatograms where sulfated carbohydrate chains usually are found. However, the binding pattern to nonacid glycolipid fractions suggests a core chain of lactose bound to the ceramide part as a tentative receptor structure. The carbohydrate binding of the bacterium might act as a first step in the bacterial invasion process of the dental pocket epithelium, subsequently leading to damage to periodontal tissue and tooth loss.
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| 2. |
- Holmgren, Daniel, et al.
(författare)
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Syncope--an unusual presentation of ventricle dysfunction in a patient with Fontan circulation.
- 2003
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Ingår i: Clinical physiology and functional imaging. - 1475-0961. ; 23:2, s. 120-2
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Tidskriftsartikel (refereegranskat)abstract
- We report a case of recurrent syncope in association with moderate ventricular dysfunction and mild AV-valve regurgitation in an 18-year-old girl, 4 years after she underwent total cavopulmonary connection surgery. Cardiac catheterization revealed a transpulmonary gradient of 1-2 mmHg. During exercise, a dramatic fall in blood pressure and blood oxygenation was observed, paralleled by an increase in heart rate and central venous pressure. Although a slight increase in pulmonary vascular resistance could not be excluded, the reaction was interpreted in terms of an extremely low transpulmonary gradient in association with ventricular dysfunction. Five months after heart transplantation, the patient has been completely free from syncope. Fontan circulation usually involves a delicate haemodynamic situation which may necessitate haemodynamic re-evaluations, including dynamic measurements of the central venous pressure during exercise. Also a moderate ventricular dysfunction may result in compromised pulmonary circulation which in turn may lead to syncope during exercise as a result of insufficient systemic circulation.
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| 3. |
- Rydberg, Annika, et al.
(författare)
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Heart rate variability in children with Fontan circulation.
- 2004
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Ingår i: Pediatric Cardiology. - New York : Springer-Verlag. - 0172-0643 .- 1432-1971. ; 25:4, s. 365-369
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Tidskriftsartikel (refereegranskat)abstract
- Heart rate variability (HRV) can be used to study cardiovascular autonomic control. This study examines HRV in children with Fontan circulation and its change over time. Thirty-four children in two groups were examined. Group A consisted of 10 patients who had undergone total cavopulmonary connection. Group B consisted of 24 healthy children/adolescents matched for gender, height, and weight. To analyze HRV parameters, all examinations included echocardiography and 24-hour ambulatory electrocardiogram. Comparing all patients and controls, there were no significant differences in HRV parameters. Analyzing subgroups of patients younger than 10 years old, two of the HRV parameters were significantly different compared to controls. For the group of patients older than 10 years, eight of the HRV parameters were significantly reduced. Most significant differences were found regarding low-frequency range (p < 0.008) and high-frequency range p < 0.008. This study confirms the finding of earlier studies that patients with Fontan circulation have a reduced HRV, and our findings indicate that there is a progressive reduction of HRV over time.
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| 4. |
- Stecksen-Blicks, Christina, et al.
(författare)
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Dental caries experience in children with congenital heart disease : a case-control study
- 2004
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Ingår i: International Journal of Paediatric Dentistry. - 0960-7439 .- 1365-263X. ; 14:2, s. 94-100
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To compare the dental health in a group of children with complex congenital heart disease with age and gender matched healthy controls. Design: Case-control study. Setting: Faculty of Medicine and Odontology/ Pediatric cardiology and Pedodontics, Umeå university, Sweden Sample and Methods: All the cases and their controls lived in the county of Västerbotten in northern Sweden. Each group comprised 41 children with a mean age of 6.5 years. Data were collected from medical and dental records. All bitewing radiographs were read separately by one of the authors. Results: Children with congenital heart disease had significantly more caries in their primary teeth than the control group. The mean dmfs-value was 5.2 + 7.0 in the cardiac group compared to 2.2 + 3.5 in the control group (p < 0.05). Twenty-six of the children had all four 6-year molars, and their mean DMFS-values were 0.9 + 1.9 in the cardiac group compared to 0.3 + 0.6 in the control group (p > 0.05). The children with congenital heart disease had received more caries prevention based on the use of fluorides than the control group. There was a significant correlation between the number of fluoride varnish treatments and the dmfs value of the child (r = 0.411, p < 0.01). Fifty-two per cent of the children in the cardiac group were prescribed fluoride tablets on one or more occasions compared to 17% in the control group (p < 0.01). Number of month on digoxin medication and the dmfs-value had a significant correlation (r = 0.368, p < 0.05). Ten of the children had been on digoxin medication between 6 and 87 months and they had a mean dmfs-value of 10.1 + 8.5. Conclusion: Swedish children with complex congenital heart disease have poorer dental health than healthy age and gender matched controls in spite of intensified preventive efforts. In many cases, intervention had been given when caries were present. A closer cooperation between paediatric cardiology and paediatric dentistry is needed.
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