| 1. |
- Eriksson, s, et al.
(författare)
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Surgical treatment of epilepsy--clinical, radiological and histopathological findings in 139 children and adults.
- 1999
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Ingår i: Acta neurologica Scandinavica. - 0001-6314. ; 99:1, s. 8-15
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Tidskriftsartikel (refereegranskat)abstract
- The present study relates clinical and radiological data to histopathological diagnoses in the first 139 patients (children and adults) in the G?teborg Epilepsy Surgery series. Temporal lobe resections were most common (54.0%) followed by frontal lobe (18.0%) and multilobar resections (11.5%). All histopathological specimens were re-evaluated in connection with this study. Parenchymal malformations and atrophic-gliotic lesions were the most common histopathological findings. Microdysgenesis was more common than major malformations (24.5% versus 11.5%). When the MRI scans were blindly re-evaluated the MRI findings correlated with histopathological diagnosis in all of the vascular malformations, in 77.8% of the tumours, in 76.5% of the cases with hippocampal sclerosis but only in 28.6% of the major cortical development malformations. Hemispherectomies carried the best seizure outcome prognosis followed by temporal lobe resections (75.0% versus 57.3% seizure free 2 years after surgery). Vascular malformations carried the best, and microdysgenesis the worst prognosis (76.9% versus 39.4% seizure free).
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| 2. |
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| 3. |
- Naredi, Silvana, 1953, et al.
(författare)
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Vasogenic edema and brain trauma.
- 1999
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Ingår i: Intensive Care Medicine. - 0342-4642 .- 1432-1238. ; 25, s. 244-245
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Forskningsöversikt (refereegranskat)
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| 4. |
- Nordborg, Claes, 1946, et al.
(författare)
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Microdysgenesis in surgical specimens from patients with epilepsy: occurrence and clinical correlations.
- 1999
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Ingår i: Journal of neurology, neurosurgery, and psychiatry. - 0022-3050. ; 67:4, s. 521-4
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Tidskriftsartikel (refereegranskat)abstract
- Malformations of cortical development are commonly associated with epilepsy. In the first 139 consecutive patients in the G?teborg epilepsy surgery series, parenchymal malformations were found in 56. 1% of the children and in 23.1% of the adults. Microdysgenesis (MDG), which was the most common parenchymal malformation, was found in 35. 1% of the children and in 16.7% of the adults. The aim of this study was to identify clinical characteristics of patients with MDG. Mental retardation was found to be significantly more common in patients with major parenchymal malformations and in patients with MDG compared with patients without parenchymal malformations. Patients with major parenchymal malformations as well as patients with MDG also had a significantly earlier onset of seizures than patients without parenchymal malformations, also when adjusting for mental retardation. Patients with MDG were in these clinical aspects shown to closely resemble patients with major malformations. These findings suggest that MDG is a pathoanatomical entity of clinical relevance, with implications both in mental retardation and in epileptogenesis.
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