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- Ditta, L. A., et al.
(författare)
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The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels
- 2019
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Ingår i: European Polymer Journal. - : Elsevier. - 0014-3057 .- 1873-1945. ; 114, s. 164-175
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Tidskriftsartikel (refereegranskat)abstract
- Nanogels are very promising biomedical nanodevices. The classic “radiation chemistry-based” approach to synthetize nanogels consists in the irradiation with pulsed electron beams of dilute, N 2 O-saturated, aqueous solutions of water-soluble polymers of the “crosslinking type”. Nanogels with controlled size and properties are produced in a single irradiation step with no recourse to initiators, organic solvents and surfactants. This paper combines experimental syntheses, performed with two e-beam irradiation setups and dose-ranges, starting from poly(N-vinyl pyrrolidone) solutions of various concentrations, both in N 2 O-saturated and air-saturated initial conditions, with the numerical simulations of the radiation chemistry of aqueous solutions of a radical scavanger exposed to the same irradiation conditions used in the experiments. This approach provides a methodology to predict the impact of system and irradiation conditions on the water radiation chemistry, which in turn affect the nanogel features in terms of molecular and physico-chemical properties. In particular, the crucial role of initial and transient concentration of molecular oxygen is revealed. This work also proposes a very simple and effective methodology to quantitatively measure the double bonds formed in the systems from disporportionation and chain scission reactions, competing with inter-/intra-molecular crosslinking.
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- Occhiuzzi, C., et al.
(författare)
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RFID epidermal sensor including hydrogel membranes for wound monitoring and healing
- 2015
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Ingår i: 2015 IEEE International Conference on RFID, RFID 2015. - : IEEE conference proceedings. - 9781479919376 ; , s. 182-188
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Konferensbidrag (refereegranskat)abstract
- This contribution experimentally demonstrates for the first time the feasibility of joint application of passive UHF RFID technology and hydrogel membranes to fabricate smart plasters able to gather and remotely transmit information on the conditions of human skin. In particular, this intelligent plaster is sensitive to temperature and fluid uptake/release and could open interesting scenarios in wound healing monitoring and drug delivery.
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- Picone, P., et al.
(författare)
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Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer’s disease
- 2016
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Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 80, s. 179-194
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Tidskriftsartikel (refereegranskat)abstract
- A growing body of evidence shows the protective role of insulin in Alzheimer’s disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer’s Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated. The insulin conjugated to the NG (NG-In) is protected by protease degradation and able to bind to insulin receptor (IR), as demonstrated by immunofluorescence measurements showing colocalization of NG-InFITC with IR. Moreover, after binding to the receptor, NG-In is able to trigger insulin signaling via AKT activation. Neuroprotection of NG-In against dysfunction induced by amyloid β (Aβ), a peptide mainly involved in AD, is verified. Finally, the potential of NG-In to be efficiently transported across the Blood Brain Barrier (BBB) is demonstrated. All together these results indicate that the synthesized NG-In is a suitable vehicle system for insulin deliver in biomedicine and a very promising tool to develop new therapies for neurodegenerative diseases.
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