| 1. |
- Sabri, M. H. M., et al.
(författare)
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Initial electric field changes of lightning flashes in tropical thunderstorms and their relationship to the lightning initiation mechanism
- 2019
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Ingår i: Atmospheric research. - : ELSEVIER SCIENCE INC. - 0169-8095 .- 1873-2895. ; 226, s. 138-151
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the key finding is that all the examined first classic Initial Breakdown (IB) pulses in tropical flashes within the reversal distance were found to be initiated by a clearly detectable Initial E-field Change or IEC (45 -CG, 32 normal IC, and 3 IC initiated by +NBE). The durations of IECs for both -CG and IC flashes in tropical storms were longer than in Florida storms. On the other hand, for the magnitudes of the E-change, the values were smaller compared to Florida storms with averages of 0.30 V/m compared to 1.65 V/m for -CG flashes, and -0.81 V/m compared to -6.30 V/m for IC flashes. The IEC process of lightning flashes in tropical regions took longer to increase the local electric field in order to produce the first IB pulse because of the smaller magnitude of E-change. On the other hand, in Florida storms, the IEC process took a shorter time to increase the local electric field to produce the first IB pulse because of the larger magnitude of E-change. We found that very high frequency (VHF) pulses for tropical thunderstorms started sometime prior to the onset of the IECs. They started between 12.69 and 251.60 mu s before the initiation of the IEC for two normal IC flashes. The first two VHF pulses were detected alone without narrow IB pulses (fast antenna and slow antenna records) or any pulses from the B-field and dE/dt records. Furthermore, the VHF pulses for three IC flashes initiated by + NBEs were also detected before the onset of the IEC. The IEC started immediately after the detection of the + NBE. It is clear that the IEC is initiated by VHF pulses. It can be suggested that lightning is initiated by Fast Positive Breakdowns or FPBs (which emit strong VHF pulses and large + NBEs) and is followed by several negative breakdowns (weak VHF pulses and/or weak NBE-type pulses) before the IEC started. For the case of normal IC flashes, several weaker VHF pulses (mean values of 41.97 mV and 46.4 mV compared to the amplitudes of the VHF pulses of + NBEs of around 800 mV) were detected before the onset of the IEC. As FPBs can occur with a wide range of VHF strengths and E-change amplitudes, it can be suggested these weak VHF pulses accompanied by narrow IB pulses or weak NBE-type pulses detected before the onset of IEC are actually FPBs followed by negative breakdowns or several attempted FPBs.
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| 2. |
- Kreins, AY, et al.
(författare)
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Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
- 2015
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 212:10, s. 1641-1662
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Tidskriftsartikel (refereegranskat)abstract
- Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, and staphylococcal abscesses. We identified seven other TYK2-deficient patients from five families and four different ethnic groups. These patients were homozygous for one of five null mutations, different from that seen in P1. They displayed mycobacterial and/or viral infections, but no HIES. All eight TYK2-deficient patients displayed impaired but not abolished cellular responses to (a) IL-12 and IFN-α/β, accounting for mycobacterial and viral infections, respectively; (b) IL-23, with normal proportions of circulating IL-17+ T cells, accounting for their apparent lack of mucocutaneous candidiasis; and (c) IL-10, with no overt clinical consequences, including a lack of inflammatory bowel disease. Cellular responses to IL-21, IL-27, IFN-γ, IL-28/29 (IFN-λ), and leukemia inhibitory factor (LIF) were normal. The leukocytes and fibroblasts of all seven newly identified TYK2-deficient patients, unlike those of P1, responded normally to IL-6, possibly accounting for the lack of HIES in these patients. The expression of exogenous wild-type TYK2 or the silencing of endogenous TYK2 did not rescue IL-6 hyporesponsiveness, suggesting that this phenotype was not a consequence of the TYK2 genotype. The core clinical phenotype of TYK2 deficiency is mycobacterial and/or viral infections, caused by impaired responses to IL-12 and IFN-α/β. Moreover, impaired IL-6 responses and HIES do not appear to be intrinsic features of TYK2 deficiency in humans.
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| 3. |
- Baharin, S. A. S., et al.
(författare)
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Wavelet Analysis of the Onset of VHF and Microwave Radiation Emitted by Lightning
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 297-300
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Konferensbidrag (refereegranskat)abstract
- Lightning flash is an electrical discharge in air (dielectric breakdown) which emits electromagnetic (FM) fields across very wide spectra from a few Hertz up to visible wavelength. Electrical breakdown process is an important event that initiates lightning. For electrical breakdown process to occur, it must fulfill two conditions which are at least has one free electron and the electric field region is more than 3 MV/m. This process starts with electron avalanche in millimeter scale then grows into streamer in centimeter scale. Lastly, from streamer it will grow into leader in meter scale. It has already established that streamer emits intensely at Very High Frequency (VHF) band as it's already proven both theoretically and experimentally. A study by Cooray, theoretically proved that emission of electron avalanche peaks at microwave band. Air-gap parallel plate antenna which could operate at 1 GHz with remote sensing is designed and simulated to measure the microwave radiation emitted by lightning. Both temporal and wavelet analyses are used to compare the onset of microwave radiation and VHF radiation in both time and frequency domains to determine electron avalanche appears at which electromagnetic band.
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| 4. |
- Bailey, D. L., et al.
(författare)
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Combined PET/MRI : Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tubingen, Germany
- 2018
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Ingår i: Molecular Imaging and Biology. - : SPRINGER. - 1536-1632 .- 1860-2002. ; 20:1, s. 4-20
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Forskningsöversikt (refereegranskat)abstract
- The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tubingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how best to characterise the tumour microenvironment, optimise the complementary information available from PET and MRI, and how advanced data mining and bioinformatics, as well as information from liquid biomarkers (circulating tumour cells and nucleic acids) and pathology, can be integrated to give a more complete characterisation of disease phenotype. Some issues that have dominated previous meetings, such as the accuracy of MR-based attenuation correction (AC) of the PET scan, were finally put to rest as having been adequately addressed for the majority of clinical situations. Likewise, the ability to standardise PET systems for use in multicentre trials was confirmed, thus removing a perceived barrier to larger clinical imaging trials. The meeting openly questioned whether PET/MRI should, in all cases, be used as a whole-body imaging modality or whether in many circumstances it would best be employed to give an in-depth study of previously identified disease in a single organ or region. The meeting concluded that there is still much work to be done in the integration of data from different fields and in developing a common language for all stakeholders involved. In addition, the participants advocated joint training and education for individuals who engage in routine PET/MRI. It was agreed that PET/MRI can enhance our understanding of normal and disrupted biology, and we are in a position to describe the in vivo nature of disease processes, metabolism, evolution of cancer and the monitoring of response to pharmacological interventions and therapies. As such, PET/MRI is a key to advancing medicine and patient care.
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| 5. |
- Seah, B. Y., et al.
(författare)
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The Performance Evaluation of Capacitive Antenna with Various Structures and Permittivity Values
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 457-460
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Konferensbidrag (refereegranskat)abstract
- This paper evaluates the capacitive antenna performance as a lightning sensor. The performance is evaluated by looking at two aspects, antenna structures and the background permittivity value of the antenna. Two experiments were carried out, Experiment A using two different structure antennas, one with its Bayonet Neill-Concelman (BNC) connector's core direct touching the top plate (DBNC) while the other was connected via single core wires (WBNC), capturing the electric field (E-field) generated by the small spark at a distance of 1 meter away from both antennas. Furthermore, both capacitive antennas with top plates directly soldered to their BNC cores were used to study their performance with and without being covered by plastic (dielectric constant of 2.25) during Experiment B. The result from Experiment A showed that WBNC has different onset polarity and significant decreased in amplitude of the signals captured compared to DBNC (mean ratio is 1.095 with range between 0.5838 and 4.528). Meanwhile, Experiment B shows that a comparable average ratio of 0.7835 and 0.7447 during the measurement where antenna A(wc) with and without the presence of plastic cover respectively.
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| 6. |
- Jansen, Willemijn J, et al.
(författare)
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Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
- 2018
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Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 75:1, s. 84-95
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.
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| 7. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
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Ingår i: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
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| 8. |
- Ong, J. Y., et al.
(författare)
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Performance Analysis of Stacked Capacitive Antenna for Lightning Remote Sensing
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 305-308
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Konferensbidrag (refereegranskat)abstract
- Antennas are the important elements in the lightning detection system. To improve performance of the lightning detection system, it is so necessary to improve the efficiency of the antennas. There are two types of antennas used in the system which are capacitive antenna for electric field sensing and loop antenna for magnetic field sensing Pi. Both of these antennas arc big in size and causing inconvenient during set up. Thus, small and portable antennas are designed. It is so important to remain or improve the sensitivity of the antennas even though it is small in size. Stacking method is used in capacitive antenna by increase copper plate layer in between the parallel plate antenna. After prototype the multi stacked capacitive antenna, performance analysis is carried out. Performances of the antennas are compared using CST simulation and hardware set up. Multi-stacked capacitive antenna is compared with the single plate antenna and found that the performance of the antenna increases as the stacked number increases.
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| 9. |
- Sabri, M. H. M., et al.
(författare)
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VHF Emissions Prior to the Onset of Initial Electric Field Changes of Intracloud Flashes
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 301-304
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Konferensbidrag (refereegranskat)abstract
- We present the observation of VHF impulses electric (E) field emissions found in two normal intracloud (IC) flashes accompanied by initial electric field changes (LECs) in a tropical thunderstorm. The data was collected on November 23rd, 2017 (within reversal distance) to our lightning sensor in Malacca, Malaysia. The durations from the onset of IECs to the first initial breakdown (IB) pulse are range between 0.68 and 0.69 ms and the magnitudes of IECs are range between 0.18 and 0.50 V/m. Besides that, before the onset of LECs there is small pulses was detected for IC flash (Nov_67) same with the VHF impulse for both IC flash. It was detected earlier before the onset of IEC by 12.69 and 251.60 mu s for the VHF impulse.
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| 10. |
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