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Polybrominated Dibe...
Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls : Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds
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- van den Berg, Martin (author)
- Institute for Risk Assessment Sciences (IRAS) and WHO Collaborating Centre for Environmental Health Risk Assessment, Utrecht University, Utrecht, The Netherlands
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- Denison, Michael S (author)
- Department of Environmental Toxicology, University of California, Davis CA, USA,Veterinary Physiology and Pharmacology, Texas A&M University, College Station TX, USA
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- Birnbaum, Linda S (author)
- National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park NC, USA
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- DeVito, Michael J (author)
- Environmental Health Sciences, Research Triangle Park NC, USA
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- Fiedler, Heidelore, 1953- (author)
- United Nations Environment Programme (UNEP), Geneva, Switzerland
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- Falandysz, Jerxy (author)
- University of Gdańsk, Gdańsk, Poland
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- Rose, Martin (author)
- Food and Environment Research Agency, York, United Kingdom
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- Schrenk, Dieter (author)
- Department of Food Chemistry & Environmental Toxicology, Technische Universität Kaiserslautern, Kaiserslautern, Germany
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Safe, Stephen (author)
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- Tohyama, Chiharu (author)
- Laboratory of Environmental Health Sciences, University of Tokyo, Tokyo, Japan
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- Tritscher, Angelika (author)
- Department of Food Safety and Zoonoses, World Health Organization (WHO), Geneva, Switzerland
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- Tysklind, Mats (author)
- Umeå universitet,Kemiska institutionen,Department of Chemistry, Umeå University, Umeå, Sweden
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- Peterson, Richard E (author)
- Department of Pharmaceutical Sciences, University of Wisconsin, Madison WI, USA
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(creator_code:org_t)
- 2013-03-14
- 2013
- English.
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In: Toxicological Sciences. - Oxfors, United Kingdom : Oxford University Press. - 1096-6080 .- 1096-0929. ; 133:2, s. 197-208
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Abstract
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- In 2011 a joint World Health Organization (WHO) and United Nations Environment Programme (UNEP) expert consultation took place, during which the possible inclusion of brominated analogues of the dioxin-like compounds in the WHO Toxicity Equivalency Factor (TEF) scheme were evaluated. The expert panel concluded that polybrominated dibenzo-p-dioxins (PBDDs), dibenzofurans (PBDFs), and some dioxin-like biphenyls (dl-PBBs) may contribute significantly in daily human background exposure to the total dioxin toxic equivalencies (TEQs). These compounds are also commonly found in the aquatic environment. Available data for fish toxicity were evaluated for possible inclusion in the WHO-UNEP TEF scheme (Van den Berg et al., 1998). Because of the limited database it was decided not to derive specific WHO-UNEP TEFs for fish, but for ecotoxicological risk assessment the use of specific relative effect potencies (REPs) from fish embryo assays is recommended. Based on the limited mammalian REP database for these brominated compounds, it was concluded that sufficient differentiation from the present TEF values of the chlorinated analogues (Van den Berg et al., 2005) was not possible. However, the REPs for PBDDs, PBDFs, and non-ortho dl-PBBs in mammals closely follow those of the chlorinated analogues, at least within one order of magnitude. Therefore, the use of similar interim TEF values for brominated and chlorinated congeners for human risk assessment is recommended, pending more detailed information in the future.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- dioxin
- halogenated hydrocarbon
- persistent organic chemicals
- polychlorinated biphenyls
- regulatory/policy
- biomarkers
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van den Berg, Ma ...
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Denison, Michael ...
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Birnbaum, Linda ...
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DeVito, Michael ...
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Fiedler, Heidelo ...
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Falandysz, Jerxy
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Rose, Martin
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Schrenk, Dieter
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Safe, Stephen
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Tohyama, Chiharu
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Tritscher, Angel ...
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Tysklind, Mats
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Peterson, Richar ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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MEDICAL AND HEAL ...
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Toxicological Sc ...
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Umeå University
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Örebro University