| 1. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 2. |
- Fernie, A. R., et al.
(författare)
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Perspectives on plant photorespiratory metabolism
- 2013
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Ingår i: Plant Biology. - : Wiley-Blackwell. - 1435-8603 .- 1438-8677. ; 15:4, s. 748-753
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Forskningsöversikt (refereegranskat)abstract
- Being intimately intertwined with (C3) photosynthesis, photorespiration is an incredibly high flux-bearing pathway. Traditionally, the photorespiratory cycle was viewed as closed pathway to refill the Calvin-Benson cycle with organic carbon. However, given the network nature of metabolism, it hence follows that photorespiration will interact with many other pathways. In this article, we review current understanding of these interactions and attempt to define key priorities for future research, which will allow us greater fundamental comprehension of general metabolic and developmental consequences of perturbation of this crucial metabolic process.
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| 3. |
- Fragopoulou, A., et al.
(författare)
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Scientific panel on electromagnetic field health risks : Consensus points, recommendations, and rationales
- 2010
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Ingår i: Reviews on Environmental Health. - 0048-7554. ; 25:4, s. 307-317
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Tidskriftsartikel (refereegranskat)abstract
- In November, 2009, a scientific panel met in Seletun, Norway, for three days of intensive discussion on existing scientific evidence and public health implications of the unprecedented global exposures to artificial electromagnetic fields (EMF). EMF exposures (static to 300 GHz) result from the use of electric power and from wireless telecommunications technologies for voice and data transmission, energy, security, military and radar use in weather and transportation. The Scientific Panel recognizes that the body of evidence on EMF requires a new approach to protection of public health; the growth and development of the fetus, and of children; and argues for strong preventative actions. New, biologically-based public exposure standards are urgently needed to protect public health worldwide.
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| 4. |
- Kokjohn, Sage L., et al.
(författare)
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Modeling Charge Preparation And Combustion In Diesel Fuel, Ethanol, And Dual-Fuel PCCI Engines
- 2011
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Ingår i: Atomization and Sprays. - 1936-2684. ; 21:2, s. 107-119
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Tidskriftsartikel (refereegranskat)abstract
- In this work, multi-dimensional computational fluid dynamics modeling predictions are compared for three different methods of achieving high-efficiency, low NOT, and soot premixed charge compression ignition (PCCI) combustion. The first method is early injection, highly dilute (i.e., low oxygen concentration), diesel fuel PCCI operation. In this method, the oxygen concentration is reduced to extend the ignition delay to allow adequate time for mixing prior to autoignition. The second method is early injection PCCI operation using neat ethanol. In this method, the fuel reactivity is sufficiently low such that PCCI combustion can be achieved without using external dilution. The final method, dual-fuel reactivity controlled compression ignition (RCCI) combustion, blends fuels with different ignition qualities in the combustion chamber to tailor the auto-ignition properties of the mixture for the specific operating condition. In this study, RCCI operation was investigated using in-cylinder fuel blending of diesel fuel and gasoline as well as diesel fuel and an E85 blend (i.e., 85% ethanol and 15% gasoline). It was found that the modeling approach used in this work is capable of capturing the bulk combustion characteristics (e.g., cylinder pressure) as well as the details of the injection event (e.g., liquid penetration) and ignition processes. The simulations were shown to provide accurate predictions of the differences in combustion characteristics of diesel fuel, ethanol, and fuel blends (i.e., gasoline + diesel fuel and E85 + diesel fuel). It was found that the ethanol PCCI and dual-fuel (gasoline + diesel fuel and E85 + diesel fuel) RCCI cases have significantly reduced rates of energy release compared to neat diesel fuel PCCI operation. The reduced energy release rates of the ethanol PCCI and dual-fuel RCCI cases may allow these modes of PCCI combustion to achieve higher engine loads than that of neat diesel PCCI.
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| 5. |
- Peterhansel, C., et al.
(författare)
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Engineering photorespiration : current state and future possibilities
- 2013
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Ingår i: Plant Biology. - : Wiley-Blackwell. - 1435-8603 .- 1438-8677. ; 15:4, s. 754-758
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Forskningsöversikt (refereegranskat)abstract
- Reduction of flux through photorespiration has been viewed as a major way to improve crop carbon fixation and yield since the energy-consuming reactions associated with this pathway were discovered. This view has been supported by the biomasses increases observed in model species that expressed artificial bypass reactions to photorespiration. Here, we present an overview about the major current attempts to reduce photorespiratory losses in crop species and provide suggestions for future research priorities.
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| 6. |
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