| 1. |
- Carlborg, Fredrik, et al.
(författare)
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RAPID PERMANENT HYDROPHILIC AND HYDROPHOBIC PATTERNING OF POLYMER SURFACES VIA OFF-STOICHIOMETRY THIOL-ENE (OSTE) PHOTOGRAFTING
- 2012
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Ingår i: Proceedings Micro Total Analysis Systems (muTAS) 2012. ; , s. 677-679
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Konferensbidrag (refereegranskat)abstract
- In this work we have developed a simple and robust method to permanently pattern alternating hydrophobic and hydrophilic surfaces in off-stoichiometry thiol-ene (OSTE) polymer microchannels. By being able to tune the number of unreacted thiol surface groups of the OSTE Thiol polymers and by taking advantage of spatially photo-controlled surface grafting of methacrylate monomers we achieve defined areas with contact angles from 20° to 115° within one single channel. The surface modification remains stable after storage in air (>2 months) or water (>24h).
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| 2. |
- Karlsson (Hillmering), Mikael, 1982-, et al.
(författare)
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High-resolution micropatterning of off-stochiometric thiol-enes (OSTE) via a novel lithography mechanism
- 2012
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Ingår i: 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2012). ; , s. 225-227
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Konferensbidrag (refereegranskat)abstract
- We present an entirely novel, self-limiting photolithography mechanism in off-stoichiometry thiol-ene (OSTE) polymers enabling high-resolution and high-aspect ratio features. The OSTE polymers have previously been shown to be promising materials for fabrication of microfluidic devices with tailored surface modifications and mechanical properties. We here introduce direct lithography for micropatterning of OSTE as an alternative to mechanical machining or casting, resulting in a simple and reliable fabrication method of self-bonding photopatterned multilayer microfluidic devices.
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| 3. |
- Pierer, Jörg, et al.
(författare)
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Photonic sensing of food allergy : integration and miniaturization
- 2012
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Ingår i: Smart Systems Integration.
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Konferensbidrag (refereegranskat)abstract
- Food allergies can provoke severe clinical reactions. Within the FP7 project POSITIVE a Lab-on-a-Chip platform for label-free quantitative allergen testing is under development. The system integrates fluidic handling, optical interrogation and a porous Silicon based bio sensor cartridge. Optical and fluidic concepts have been derived and partially tested with positive results on lab bench level. Further effort has to be spent on higher system integration and miniaturization of the components as well as signal processing and data evaluation. Model tests based on the immobilization of allergens and molecular recognition by specific antibodies have been established proofing the pre-treated porous Silicon membranes bio assay suitability.
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| 4. |
- Saharil, Farizah, et al.
(författare)
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Biocompatible "click" wafer bonding for microfluidic devices
- 2012
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Ingår i: Lab on a Chip. - : RSC Publishing. - 1473-0197 .- 1473-0189. ; 12:17, s. 3032-3035
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a novel dry wafer bonding concept designed for permanent attachment of micromolded polymer structures to surface functionalized silicon substrates. The method, designed for simultaneous fabrication of many lab-on-chip devices, utilizes a chemically reactive polymer microfluidic structure, which rapidly bonds to a functionalized substrate via "click" chemistry reactions. The microfluidic structure consists of an off-stoichiometry thiol-ene (OSTE) polymer with a very high density of surface bound thiol groups and the substrate is a silicon wafer that has been functionalized with common bio-linker molecules. We demonstrate here void free, and low temperature (<37 degrees C) bonding of a batch of OSTE microfluidic layers to a silane functionalized silicon wafer.
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| 5. |
- Saharil, Farizah, et al.
(författare)
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Dry Transfer Bonding of Porous Silicon Membranes to OSTE(+) Polymer Microfluidic Devices
- 2012
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Ingår i: Proceedings IEEE International Conference on Micro Electro MechanicalSystems (MEMS). - : IEEE. - 9781467303255 - 9781467303248 ; , s. 232-234
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Konferensbidrag (refereegranskat)abstract
- We present low temperature transfer bonding of porous silicon membranes to polymeric microfluidic devices, using neither adhesives nor bond surface treatment. The transfer is enabled by a novel dual cure ternary monomer system containing thiolene and epoxy. The ability of the epoxy to react with almost any dry substrate provides a very versatile fabrication method. We characterize the two stage curing mechanism, describe the device fabrication, and evaluate the bond strength.
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| 6. |
- Saharil, Farizah, 1976-, et al.
(författare)
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SUPERIOR DRY BONDING OF OFF-STOICHIOMETRY THIOL-ENEEPOXY (OSTE(+)) POLYMERS FOR HETEROGENEOUS MATERIALLABS-ON-CHIP
- 2012
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Ingår i: Proceedings Micro Total Analysis Systems (muTAS) 2012. - 9780979806452 ; , s. 1831-1833
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Konferensbidrag (refereegranskat)abstract
- We demonstrate biocompatible bonding to a multitude of LoC substrates using OSTE(+), a novel polymer formulation with a unique dual cure system developed specifically for microfluidic applications. OSTE(+) allows for soft lithography microstructuring, strong biocompatible dry bonding to almost any substrate during LoCmanufacturing, while simultaneously mimicking the mechanical properties found in thermoplastic polymers, hence allowing for true prototyping of commercial LoCs. In this work, we describe the simple micropatterning process, curing mechanisms and show leak-free dry bonding to nine different substrate materials. Uniquely, strong bonding is achieved to COC, the thermoplastic of choice for microfluidics, which opens up the possibility of hybrid thermoplastic/OSTE(+) LoCs. In this work, we demonstrate bonding to nine different untreated substrates at 37°C and room temperature to demonstrate good bonding properties even at lower temperature. We also show the high resilience of the epoxy bond by immersing an aluminum substrate with a bonded OSTE(+) layer into boiling water while simultaneously subjecting the assembly to pressurized air.
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