| 1. |
- Lindholm, Anna, et al.
(författare)
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Utvärdering av förståelse på skriftlig tentamen
- 2011
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Konferensbidrag (refereegranskat)abstract
- I tidigare studier har det visats att examinationen i hög grad styr hur studenterna kommer att studera under en kurs. Därför är det viktigt att examinationen inte bara testar ytliga kunskaper och beräkningsförmåga, utan även förståelse. I denna artikel diskuteras olika sätt att utvärdera studenternas förståelse genom att analysera resultaten på skriftliga tentamina. En fallstudie på Institutionen för reglerteknik vid Lunds tekniska högskola presenteras och möjliga åtgärder för att öka förståelsen hos studenterna diskuteras.
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| 2. |
- Bang, Charlotte Sahlberg, 1967-, et al.
(författare)
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Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).
- 2014
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Ingår i: Microbial Pathogenesis. - London : Elsevier. - 0882-4010 .- 1096-1208. ; 66, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- Carbon monoxide (CO) releasing molecules (CO-RMs) have been shown to inhibit growth of commensal Escherichia coli (E. coli). In the present study we examined the effect of CORM-2 on uropathogenic E. coli (UPEC) that produces extended-spectrum β-lactamase (ESBL). Viability experiments showed that CORM-2 inhibited the growth of several different ESBL-producing UPEC isolates and that 500 μM CORM-2 had a bactericidal effect within 4 h. The bactericidal effect of CORM-2 was significantly more pronounced than the effect of the antibiotic nitrofurantoin. CORM-2 demonstrated a low level of cytotoxicity in eukaryotic cells (human bladder epithelial cell line 5637) at the concentrations and time-points where the antibacterial effect was obtained. Real-time RT-PCR studies of different virulence genes showed that the expression of capsule group II kpsMT II and serum resistance traT was reduced and that some genes encoding iron acquisition systems were altered by CORM-2. Our results demonstrate that CORM-2 has a fast bactericidal effect against multiresistant ESBL-producing UPEC isolates, and also identify some putative UPEC virulence factors as targets for CORM-2. CO-RMs may be candidate drugs for further studies in the field of finding new therapeutic approaches for treatment of uropathogenic ESBLproducing E. coli.
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| 3. |
- Bang, Charlotte Sahlberg, 1967-, et al.
(författare)
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The antibacterial effect of nitric oxide against ESBL-producing uropathogenic E-coli is improved by combination with miconazole and polymyxin B nonapeptide
- 2014
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Ingår i: BMC Microbiology. - London : BioMed Central. - 1471-2180. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nitric oxide (NO) is produced as part of the host immune response to bacterial infections, including urinary tract infections. The enzyme flavohemoglobin, coded by the hmp gene, is involved in protecting bacterial cells from the toxic effects of NO and represents a potentially interesting target for development of novel treatment concepts against resistant uropathogenic bacteria. The aim of the present study was to investigate if the in vitro antibacterial effects of NO can be enhanced by pharmacological modulation of the enzyme flavohemoglobin.Results: Four clinical isolates of multidrug-resistant extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli were included in the study. It was shown that the NO-donor substance DETA/NO, but not inactivated DETA/NO, caused an initial growth inhibition with regrowth noted after 8 h of exposure. An hmp-deficient strain showed a prolonged growth inhibition in response to DETA/NO compared to the wild type. The imidazole antibiotic miconazole, that has been shown to inhibit bacterial flavohemoglobin activity, prolonged the DETA/NO-evoked growth inhibition. When miconazole was combined with polymyxin B nonapeptide (PMBN), in order to increase the bacterial wall permeability, DETA/NO caused a prolonged bacteriostatic response that lasted for up to 24 h.Conclusion: An NO-donor in combination with miconazole and PMBN showed enhanced antimicrobial effects and proved effective against multidrug-resistant ESBL-producing uropathogenic E. coli.
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| 4. |
- Borggren, Jesper, et al.
(författare)
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Temperature imaging in low-pressure flames using diode lasers
- 2014
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Ingår i: Imaging and Applied Optics - Laser Applications to Chemical, Security and Environmental Analysis, LACSEA 2014. - Washington, D.C. : OSA. - 2162-2701. - 9781557523082 - 9781557523082
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Konferensbidrag (refereegranskat)abstract
- We present a calibration free technique for spatially resolved imaging of flame temperature. Its application is demonstrated in a low pressure premixed methane flame seeded with indium. Temperature measurements over a range of equivalence ratios are investigated.
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| 5. |
- Hogstedt, Lasse, et al.
(författare)
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Low-noise mid-IR upconversion detector for improved IR-degenerate four-wave mixing gas sensing
- 2014
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Ingår i: Optics Letters. - 0146-9592. ; 39:18, s. 5321-5324
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Tidskriftsartikel (refereegranskat)abstract
- We compare a nonlinear upconversion detector with a conventional cryogenic InSb detector for the detection of coherent infrared light showing near-shot-noise-limited performance in the upconversion system. The InSb detector is limited by dark noise, which results in a 500 times lower signal-to-noise ratio. The two detectors are compared for the detection of a coherent degenerate four-wave mixing (DFWM) signal in the mid-infrared, and applied to measure trace-level acetylene in a gas flow at atmospheric pressure, probing its fundamental rovibrational transitions. In addition to lower noise, the upconversion system provides image information of the signal, thus adding new functionality compared to standard point detection methods. We further show that the upconversion detector system can be implemented as a simple replacement of the cryogenic detector. (C) 2014 Optical Society of America
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| 6. |
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| 7. |
- Sahlberg, Anna-Lena, et al.
(författare)
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Upconversion imager improves IR gas sensing
- 2014
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Ingår i: Laser Focus World. - 1043-8092. ; 50:11, s. 51-53
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A nonlinear upconversion detector shows near-shot-noise-limited performance and compares favorably-while adding additional imaging information-to conventional cryogenic detectors in the measurement of tracelevel gases at atmospheric pressure.
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| 8. |
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| 9. |
- Sahlberg-Blom, Eva, et al.
(författare)
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Assistant nurses’ descriptions of signs of dying among older people in nursing homes
- 2013
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Ingår i: Vård i Norden. - : SAGE Publications. - 0107-4083 .- 1890-4238. ; 33:3, s. 20-24
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Tidskriftsartikel (refereegranskat)abstract
- Background: In Sweden, assistant nurses are the group of professionals who have a great deal of contact with older, dying persons in nursing homes. They have substantial experience in this area. It is therefore important that their voices are heard about their experience of how they identify that an older person is dying.Aim: The purpose was to describe assistant nurses’ experiences of signs of dying among older people in nursing homes.Method: A qualitative manifest content analysis was used. Four interviews were performed with eight experienced assistant nurses, individually or in groups, from two nursing homes.Findings: The result is characterized by the assistant nurses’ descriptions of both subtle and manifest signs that an older person is dying. The analysis led to two categories: “the older person expresses insight” and “the older person’s body changes”. The first of these mainly involved observations of psychosocial changes, while the second mainly contained observations of bodily changes.Conclusion: The clinical experiences as the assistant nurses achieve give valuable incitements for creating good palliative care. The assistant nurses must be seen as a significant part of the care team. They should be offered continuous education and support regarding palliative care in order to develop their skills and practical knowledge.
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