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Graft-versus-Host D...
Graft-versus-Host Disease Prophylaxis with PostTransplantation Cyclophosphamide in Chronic Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplantation from an Unrelated or Mismatched Related Donor : A Comparative Study from the Chronic Malignancies Working Party of the EBMT (CMWP-EBMT)
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- Ortí, Guillermo (författare)
- Vall dHebron Univ Hosp, Vall dHebron Inst Oncol, Dept Hematol, Barcelona, Spain.
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- Gras, Luuk (författare)
- EBMT Stat Unit, Leiden, Netherlands.
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- Koster, Linda (författare)
- EBMT Leiden Study Unit, Leiden, Netherlands.
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- Kulagin, Aleksander (författare)
- Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia.
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- Byrne, Jenny (författare)
- Univ Nottingham, Nottingham, England.
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- Apperley, Jane F. (författare)
- Imperial Coll, London, England.
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- Halaburda, Kazimierz (författare)
- Inst Hematol & Transfus Med, Warsaw, Poland.
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- Blau, Igor Wolfgang (författare)
- Charite Univ Med Berlin, Berlin, Germany.
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- Clark, Andrew (författare)
- Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland.
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- Kröger, Nicolaus (författare)
- Univ Hosp Eppendorf, Hamburg, Germany.
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- Griskevicius, Laimonas (författare)
- Vilnius Univ Hosp, Vilnius, Lithuania.
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- Carlson, Kristina (författare)
- Univ Hosp, Uppsala, Sweden
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- Collin, Matthew (författare)
- Northern Ctr Bone Marrow Transplantat, Newcastle Upon Tyne, Tyne & Wear, England.
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- Bloor, Adrian (författare)
- Christie NHS Trust Hosp, Manchester, Lancs, England.
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- Raiola, Anna Maria (författare)
- IRCCS Osped Policlin San Martino, Genoa, Italy.
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- Blaise, Didier (författare)
- Programme Transplantat & Therapie Cellulaire, Marseille, France.
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- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia.
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- López-Corral, Lucia (författare)
- Hosp Univ Salamanca, Dept Hematol, IBSAL, CIBERONC, Salamanca, Spain.
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- Sakellari, Ioanna (författare)
- George Papanicolaou Gen Hosp, Thessaloniki, Greece.
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- Beguin, Yves (författare)
- Univ Liege, Liege, Belgium.;CHU Liege, Liege, Belgium.
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- Wrobel, Tomasz (författare)
- Wroclaw Med Univ, Wroclaw, Poland.
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- de Rosa, Luca (författare)
- Osped S Camillo Forlanini, Rome, Italy.
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- de Lavallade, Hughes (författare)
- Guys & St Thomas NHS Fdn Trust, London, England.
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- Hayden, Patrick J. (författare)
- Trinity Coll Dublin, St Jamess Hosp, Dublin, Ireland.
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- McLornan, Donal (författare)
- Univ Coll Hosp, London, England.
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- Chalandon, Yves (författare)
- Univ Geneva, Hop Univ Geneva, Div Hematol, Geneva, Switzerland.;Univ Geneva, Hop Univ Geneve, Fac Med, Geneva, Switzerland.
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- Yakoub-Agha, Ibrahim (författare)
- Univ Lille, CHU Lille, INSERM, U1286,Infinite, F-59000 Lille, France.
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Vall dHebron Univ Hosp, Vall dHebron Inst Oncol, Dept Hematol, Barcelona, Spain EBMT Stat Unit, Leiden, Netherlands. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 30:1, s. 93.e1-93.e12
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Outcomes following allogeneic hematopoietic cell transplantation (allo-HCT) for chronic myeloid leukemia (CML) with post-transplantation cyclophosphamide (PTCy) using an unrelated donor (UD) or a mismatched related donor (MMRD) remain unknown. We report a retrospective comparison of PTCy-based allo-HCT from a UD, non-PTCy allo-HCT from a UD, and PTCy allo-HCT from an MMRD. Inclusion criteria were adult patients with CML undergoing first allo-HCT between 2012 and 2019 from a UD with either PTCy or non-PTCy graft-versus-host disease (GVHD) prophylaxis or from an MMRD using PTCy. The primary endpoint was GVHD-free/relapse-free survival (GRFS). A total of 1341 patients were included (82% in the non-PTCy UD cohort). With a median follow-up of 34.9 months, the 3-year GRFS was 43% in the non-PTCy cohort, 37% in the PTCy-UD cohort, and 39% PTCy-MMRD cohort (P = .15). Multivariable analyses revealed no significant differences among the 3 cohorts in terms of overall survival (OS), progression-free survival, RI, and nonrelapse mortality. Factors independently associated with worse OS in the overall cohort were Karnofsky Performance Status <90 (hazard ratio [HR], 1.86; 95% confidence interval [CI], 1.41 to 2.45; P < .001), older age (HR, 1.24, 95% CI, 1.11 to 1.38; P < .001), and disease stage (compared to chronic phase [CP] 1): blast phase (HR, 2.25; 95% CI, 1.60 to 3.16; P < .001), accelerated phase (HR, 1.63; 95% CI, 1.05 to 2.54; P = .03), and CP >2 (HR, 1.58; 95% CI, 1.15 to 2.17; P = .005). These results suggest that allo-HCT in patients with CML using either a UD or an MMRD with PTCy-based GVHD prophylaxis are feasible transplantation, platforms and that the disease stage at allo-HCT remains a major prognostic factor, highlighting the importance of closely monitoring CML patients and proposing transplantation when indicated when still in CP1.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Allogeneic hematopoietic cell transplantation
- Chronic myeloid
- leukemia
- Post-transplantation
- cyclophosphamide
- Unrelated donor
- Haploidentical donor
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Ortí, Guillermo
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Gras, Luuk
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Koster, Linda
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Kulagin, Aleksan ...
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Byrne, Jenny
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Apperley, Jane F ...
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Halaburda, Kazim ...
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Blau, Igor Wolfg ...
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Clark, Andrew
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Kröger, Nicolaus
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Griskevicius, La ...
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Carlson, Kristin ...
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Collin, Matthew
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Bloor, Adrian
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Raiola, Anna Mar ...
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Blaise, Didier
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Aljurf, Mahmoud
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López-Corral, Lu ...
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Sakellari, Ioann ...
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Beguin, Yves
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Wrobel, Tomasz
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de Rosa, Luca
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de Lavallade, Hu ...
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Hayden, Patrick ...
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McLornan, Donal
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Chalandon, Yves
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Yakoub-Agha, Ibr ...
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