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- Beral, V., et al.
(författare)
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Ovarian Cancer and Body Size : Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies
- 2012
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Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 9:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p<0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p<0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI, 1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade.
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- Beral, V., et al.
(författare)
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Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies
- 2012
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Ingår i: The Lancet Oncology. - 1474-5488. ; 13:9, s. 946-956
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Tidskriftsartikel (refereegranskat)abstract
- Background Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence. Methods Eligible epidemiological studies were identified by electronic searches, review articles, and discussions with colleagues. Individual participant data for 28 114 women with and 94 942 without ovarian cancer from 51 epidemiological studies were analysed centrally, yielding adjusted relative risks (RRs) of ovarian cancer in smokers compared with never smokers. Findings After exclusion of studies with hospital controls, in which smoking could have affected recruitment, overall ovarian cancer incidence was only slightly increased in current smokers compared with women who had never smoked (RR 1.06, 95% CI 1.01-1.11, p=0.01). Of 17 641 epithelial cancers with specified histology, 2314 (13%) were mucinous, 2360 (13%) endometrioid, 969 (5%) clear-cell, and 9086 (52%) serous. Smoking-related risks varied substantially across these subtypes (p(heterogeneity)<0.0001). For mucinous cancers, incidence was increased in current versus never smokers (1.79, 95% CI 1.60-2.00, p<0.0001), but the increase was mainly in borderline malignant rather than in fully malignant tumours (2.25, 95% CI 1.91-2.65 vs 1.49, 1.28-1.73; p(heterogeneity)=0.01; almost half the mucinous tumours were only borderline malignant). Both endometrioid (0.81, 95% CI 0.72-0.92, p=0.001) and clear-cell ovarian cancer risks (0.80, 95% CI 0.65-0.97, p=0.03) were reduced in current smokers, and there was no significant association for serous ovarian cancers (0.99, 95% CI 0.93-1.06, p=0.8). These associations did not vary significantly by 13 sociodemographic and personal characteristics of women including their body-mass index, parity, and use of alcohol, oral contraceptives, and menopausal hormone therapy. Interpretation The excess of mucinous ovarian cancers in smokers, which is mainly of tumours of borderline malignancy, is roughly counterbalanced by the deficit of endometrioid and clear-cell ovarian cancers. The substantial variation in smoking-related risks by tumour subtype is important for understanding ovarian carcinogenesis.
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- Mikac, B., et al.
(författare)
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Availability aspects of self-healing optical nodes designed by architecture on demand
- 2014
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Ingår i: International Conference on Transparent Optical Networks. - 9781479956005
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Konferensbidrag (refereegranskat)abstract
- The paper demonstrates the concept of optical networks with nodes implemented by the architecture on demand (AoD) and proposes a procedure for finding out possible benefits of AoD application, related to node and network availability. AoD node structure enables efficient failure management by creating a set of redundant components, which can be used for self-healing of optical nodes after failure. Availability evaluation procedure is based on Monte Carlo simulation of times to failure/repair of network components. A case study network with AoD nodes is compared to the network with hard-wired nodes in regard to availability performance, and results are presented.
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- Quiquet, A., et al.
(författare)
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Sensitivity of a Greenland ice sheet model to atmospheric forcing fields
- 2012
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Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0424. ; 6:5, s. 999-1018
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Tidskriftsartikel (refereegranskat)abstract
- Predicting the climate for the future and how it will impact ice sheet evolution requires coupling ice sheet models with climate models. However, before we attempt to develop a realistic coupled setup, we propose, in this study, to first analyse the impact of a model simulated climate on an ice sheet. We undertake this exercise for a set of regional and global climate models. Modelled near surface air temperature and precipitation are provided as upper boundary conditions to the GRISLI (GRenoble Ice Shelf and Land Ice model) hybrid ice sheet model (ISM) in its Greenland configuration. After 20 kyrs of simulation, the resulting ice sheets highlight the differences between the climate models. While modelled ice sheet sizes are generally comparable to the observed one, there are considerable deviations among the ice sheets on regional scales. These deviations can be explained by biases in temperature and precipitation near the coast. This is especially true in the case of global models. But the deviations between the climate models are also due to the differences in the atmospheric general circulation. To account for these differences in the context of coupling ice sheet models with climate models, we conclude that appropriate downscaling methods will be needed. In some cases, systematic corrections of the climatic variables at the interface may be required to obtain realistic results for the Greenland ice sheet (GIS)
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