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Visualization and A...
Visualization and Analysis of Superparamagnetic Iron Oxide Nanoparticles in the Inner Ear by Light Microscopy and Energy Filtered TEM
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- Thaler, Marlene (author)
- Carl Zeiss NTS GmbH
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- Roy, Suomen (author)
- Medical University of Innsbruck
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- Fornara, Andrea, 1980- (author)
- KTH,Funktionella material, FNM
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- Bitsche, Mario (author)
- Medical University of Innsbruck
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- Qin, Jian (author)
- KTH,Funktionella material, FNM
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- Muhammed, Mamoun (author)
- KTH,Funktionella material, FNM
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- Salvenmoser, Willi (author)
- University of Innsbruck
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- Rieger, Gunde (author)
- Medical University of Innsbruck
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- Schrott Fischer, Anneliese (author)
- Medical University of Innsbruck
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- Glueckert, Rudolf (author)
- Medical University of Innsbruck
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Nanomedicine: Nanotechnology, Biology, and Medicine. - : Elsevier BV. - 1549-9634. ; 7:3, s. 360-369
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Nanoparticles as potential carriers for local drug transfer are an alternative to systemic drug delivery into the inner ear. We report on the first in vitro tests of a new ferrogel consisting of superparamagnetic iron oxide nanoparticles (SPIONs) and a Pluronic (R) F127 (PF127) copolymer. Pluronic copolymers possess a unique viscosity-adjustable property that makes PF127 gels easy to handle compared to conventional cross-linked hydrogels. This ferrogel was successfully tested in cadaver human temporal bones as well as in organotypic explant cultures of mouse inner ears. SPIONs were identified by light microscopy and localized with different imaging modes in energy-filtered transmission electron microscopy. Our approach shows a promising possibility to use iron oxide nanoparticles, which are suitable for visualization and characterization at both the light- and electron-microscopic levels. From the Clinical Editor: The authors report the first in vitro tests of a new ferrogel consisting of superparamagnetic iron oxide nanoparticles (SPIONs) and a Pluronic (R) F127 (PF127) copolymer for drug delivery in the inner ear, demonstrasting a promising possibility to use iron oxide nanoparticles, which are suitable for visualization and characterization at both the light- and electron-microscopic levels.
Keyword
- Energy filtered transmission electron microscopy
- Organotypic inner ear explant culture
- Human temporal bone
- Iron oxide nanoparticles
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thaler, Marlene
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Roy, Suomen
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Fornara, Andrea, ...
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Bitsche, Mario
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Qin, Jian
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Muhammed, Mamoun
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Salvenmoser, Wil ...
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Rieger, Gunde
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Schrott Fischer, ...
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Glueckert, Rudol ...
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- Articles in the publication
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Nanomedicine: Na ...
- By the university
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Royal Institute of Technology