| 1. |
- Ederle, Joerg, et al.
(författare)
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Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- 2010
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Ingår i: The Lancet. - 1474-547X. ; 375:9719, s. 985-997
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Tidskriftsartikel (refereegranskat)abstract
- Background Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.16-2.45, p=0.006), Risks of any stroke (65 vs 35 events; HR 1.92, 1.27-2.89) and all-cause death (19 vs seven events; HR 2.76, 1.16-6.56) were higher in the stenting group than in the endarterectomy group. Three procedural myocardial infarctions were recorded in the stenting group, all of which were fatal, compared with four, all non-fatal, in the endarterectomy group. There was one event of cranial nerve palsy in the stenting group compared with 45 in the endarterectomy group. There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). Interpretation Completion of long-term follow-up is needed to establish the efficacy of carotid artery stenting compared with endarterectomy. In the meantime, carotid endarterectomy should remain the treatment of choice for patients suitable for surgery.
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| 2. |
- Smiljanic, R., et al.
(författare)
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The Gaia-ESO Survey: The analysis of high-resolution UVES spectra of FGK-type stars
- 2014
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 570
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Tidskriftsartikel (refereegranskat)abstract
- Context. The ongoing Gaia-ESO Public Spectroscopic Survey is using FLAMES at the VLT to obtain high-quality medium-resolution Giraffe spectra for about 10(5) stars and high-resolution UVES spectra for about 5000 stars. With UVES, the Survey has already observed 1447 FGK-type stars. Aims. These UVES spectra are analyzed in parallel by several state-of-the-art methodologies. Our aim is to present how these analyses were implemented, to discuss their results, and to describe how a final recommended parameter scale is defined. We also discuss the precision (method-to-method dispersion) and accuracy (biases with respect to the reference values) of the final parameters. These results are part of the Gaia-ESO second internal release and will be part of its first public release of advanced data products. Methods. The final parameter scale is tied to the scale defined by the Gaia benchmark stars, a set of stars with fundamental atmospheric parameters. In addition, a set of open and globular clusters is used to evaluate the physical soundness of the results. Each of the implemented methodologies is judged against the benchmark stars to define weights in three different regions of the parameter space. The final recommended results are the weighted medians of those from the individual methods. Results. The recommended results successfully reproduce the atmospheric parameters of the benchmark stars and the expected T-eff-log g relation of the calibrating clusters. Atmospheric parameters and abundances have been determined for 1301 FGK-type stars observed with UVES. The median of the method-to-method dispersion of the atmospheric parameters is 55K for T-eff, 0.13dex for log g and 0.07 dex for [Fe/H]. Systematic biases are estimated to be between 50-100 K for T-eff, 0.10-0.25 dex for log g and 0.05-0.10 dex for [Fe/H]. Abundances for 24 elements were derived: C, N, O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Mo, Ba, Nd, and Eu. The typical method-to-method dispersion of the abundances varies between 0.10 and 0.20 dex. Conclusions. The Gaia-ESO sample of high-resolution spectra of FGK-type stars will be among the largest of its kind analyzed in a homogeneous way. The extensive list of elemental abundances derived in these stars will enable significant advances in the areas of stellar evolution and Milky Way formation and evolution.
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| 3. |
- Cantat-Gaudin, T., et al.
(författare)
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The Gaia-ESO Survey: Stellar content and elemental abundances in the massive cluster NGC 6705
- 2014
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 569
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Tidskriftsartikel (refereegranskat)abstract
- Context. Chemically inhomogeneous populations are observed in most globular clusters, but not in open clusters. Cluster mass seems to play a key role in the existence of multiple populations. Aims. Studying the chemical homogeneity of the most massive open clusters is needed to better understand the mechanism of their formation and determine the mass limit under which clusters cannot host multiple populations. Here we studied NGC 6705, which is a young and massive open cluster located towards the inner region of the Milky Way. This cluster is located inside the solar circle. This makes it an important tracer of the inner disk abundance gradient. Methods. This study makes use of BVI and ri photometry and comparisons with theoretical isochrones to derive the age of NGC 6705. We study the density profile of the cluster and the mass function to infer the cluster mass. Based on abundances of the chemical elements distributed in the first internal data release of the Gaia-ESO Survey, we study elemental ratios and the chemical homogeneity of the red clump stars. Radial velocities enable us to study the rotation and internal kinematics of the cluster. Results. The estimated ages range from 250 to 316 Myr, depending on the adopted stellar model. Luminosity profiles and mass functions show strong signs of mass segregation. We derive the mass of the cluster from its luminosity function and from the kinematics, finding values between 3700 M-circle dot and 11 000 M-circle dot. After selecting the cluster members from their radial velocities, we obtain a metallicity of [Fe/H] = 0.10 +/- 0.06 based on 21 candidate members. Moreover, NGC 6705 shows no sign of the typical correlations or anti-correlations between Al, Mg, Si, and Na, which are expected in multiple populations. This is consistent with our cluster mass estimate, which is lower than the required mass limit proposed in the literature to develop multiple populations.
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| 4. |
- Magrini, L., et al.
(författare)
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The Gaia-ESO Survey: Abundance ratios in the inner-disk open clusters Trumpler 20, NGC 4815, NGC 6705
- 2014
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 563
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Tidskriftsartikel (refereegranskat)abstract
- Context. Open clusters are key tools to study the spatial distribution of abundances in the disk and their evolution with time. Aims. Using the first release of stellar parameters and abundances of the Gaia-ESO Survey, we analyse the chemical properties of stars in three old/intermediate-age open clusters, namely NGC 6705, NGC 4815, and Trumpler 20, which are all located in the inner part of the Galactic disk at Galactocentric radius R-GC similar to 7 kpc. We aim to prove their homogeneity and to compare them with the field population. Methods. We study the abundance ratios of elements belonging to two different nucleosynthetic channels: alpha-elements and iron-peak elements. For each element, we analyse the internal chemical homogeneity of cluster members, and we compare the cumulative distributions of cluster abundance ratios with those of solar neighbourhood turn-off stars and of inner-disk/bulge giants. We compare the abundance ratios of field and cluster stars with two chemical evolution models that predict different alpha-enhancement dependences on the Galactocentric distance due to different assumptions on the infall and star-formation rates. Results. The main results can be summarised as follows: i) cluster members are chemically homogeneous within 3 sigma in all analysed elements; ii) the three clusters have comparable [El/Fe] patterns within similar to 1 sigma, but they differ in their global metal content [El/H] with NGC 4815 having the lowest metallicity; their [El/Fe] ratios show differences and analogies with those of the field population, in both the solar neighbourhood and the bulge/inner disk; iii) comparing the abundance ratios with the results of two chemical evolution models and with field star abundance distributions, we find that the abundance ratios of Mg, Ni, and Ca in NGC 6705 might require an inner birthplace, implying a subsequent variation in its R-GC during its lifetime, which is consistent with previous orbit determination. Conclusions. Using the results of the first internal data release, we show the potential of the Gaia-ESO Survey through a homogeneous and detailed analysis of the cluster versus field populations to reveal the chemical structure of our Galaxy using a completely uniform analysis of different populations. We verify that the Gaia-ESO Survey data are able to identify the unique chemical properties of each cluster by pinpointing the composition of the interstellar medium at the epoch and place of formation. The full dataset of the Gaia-ESO Survey is a superlative tool to constrain the chemical evolution of our Galaxy by disentangling different formation and evolution scenarios.
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| 5. |
- Donati, P., et al.
(författare)
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The Gaia-ESO Survey : Reevaluation of the parameters of the open cluster Trumpler 20 using photometry and spectroscopy
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 561, s. A94-
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Tidskriftsartikel (refereegranskat)abstract
- Trumpler 20 is an old open cluster (OC) located toward the Galactic centre, at about 3 kpc from the Sun and similar to 7 kpc from the Galactic centre. Its position makes this cluster particularly interesting in the framework of the chemical properties of the Galactic disc because very few old OCs reside in the inner part of the disc. For this reason it has been selected as a cluster target of the Gaia-ESO Survey, and spectra of many stars in the main-sequence and red-clump phases are now available. Moreover, although it has been studied by several authors in the past, no consensus on the evolutionary status of Tr 20 has been reached. The heavy contamination of field stars (the line of sight of Tr 20 crosses the Carina spiral arm) complicates a correct interpretation. Another interesting aspect of the cluster is that it shows a broadened main-sequence turn-off and a prominent and extended red-clump, characteristics that are not easily explained by classical evolutionary models. Exploiting both spectroscopic information from the Gaia-ESO Survey (and the ESO archive) and literature photometry, we obtain a detailed and accurate analysis of the properties of the cluster. We make use of the first accurate metallicity measurement ever obtained from several spectra of red clump stars, and of cluster membership determination using radial velocities. According to the evolutionary models adopted, we find that Tr 20 has an age in the range 1.35-1.66 Gyr, an average reddening E(B - V) in the range 0.31-0.35 mag, and a distance modulus (m - M)(0) between 12.64 and 12.72 mag. The spectroscopic metallicity is [Fe/H] = +0.17 dex. We discuss the structural properties of the object and constrain possible hypotheses for its broadened upper main sequence by estimating the effect of differential reddening and its extended red clump.
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