| 1. |
- Andersson, Johnn, 1983, et al.
(författare)
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Photovoltaics in Sweden – Success or failure?
- 2021
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Ingår i: Renewable and Sustainable Energy Reviews. - : Elsevier BV. - 1879-0690 .- 1364-0321. ; 143
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Tidskriftsartikel (refereegranskat)abstract
- Promoting global energy transitions while stimulating domestic industrialization requires national policymaking that shapes technological innovation towards specific outcomes. Although this is inherently difficult, historical case studies may bring a better understanding of innovation dynamics and thereby guide the design of future policy interventions. The purpose of this paper is to review and analyze the emergence of Swedish photovoltaics technology from a policy perspective. Our main aim is to provide a retrospective account of historical developments, but we also derive more general insights about technological innovation and related policy challenges. The paper departs from an adapted analytical framework based on the technological innovation systems approach. Our review identifies four decades of Swedish research that has largely failed to drive domestic commercialization, the rise and fall of an industry that mainly served international markets, and a rapidly growing domestic market based on imported products. This situation is the result of mismatches and fragmentation among key innovation processes, which have not been addressed by strategic policy interventions. We suggest that policymakers should promote a full range of innovation processes and consider making innovation support subject to a payback mechanism that delivers a return on public investments even if industries and markets emerge abroad. Our study also demonstrates how the technological innovation systems approach can be extended to include the function commercialization and emphasizes the importance of paying attention to the directionality of technological innovation processes.
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| 2. |
- Andersson, Johnn, 1983, et al.
(författare)
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The outcomes of directionality: Towards a morphology of sociotechnical systems
- 2021
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Ingår i: Environmental Innovation and Societal Transitions. - : Elsevier BV. - 2210-4224 .- 2210-4232. ; 40, s. 108-131
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Tidskriftsartikel (refereegranskat)abstract
- The sustainability transitions literature departs from the idea that grand challenges such as climate change and rising inequality call for far-reaching changes in sociotechnical systems of production and consumption. This implies a dual interest in the directionality of innovation; some directions of change can be perceived as more desirable, while others may be more plausible due to the path dependent nature of sociotechnical change. The specific characteristics of the potential outcomes of directionality have, however, received little attention. Our aim is therefore to unpack and conceptualize the multidimensional space in which sociotechnical systems may adopt different shapes and configurations. We also provide three illustrative empirical examples where directionality has resulted in systems with different technical, social and spatial characteristics. The ideas put forward in this paper can be seen as a contribution to a morphology of sociotechnical systems and thereby support efforts to investigate or promote specific directions of change.
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| 3. |
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| 4. |
- Lamb, David, et al.
(författare)
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RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
- 2021
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Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods: IL-17 immunohistochemistry was performed in severe asthma bronchial biopsies (specificity confirmed with in situ hybridization). Primary human small airway epithelial cells in air liquid interface and primary bronchial smooth muscle cells were stimulated with recombinant human IL-17 and/or IL-22 and pro-inflammatory cytokines measured. Balb/c mice were challenged intratracheally with IL-17 and/or IL-22 and airway hyperreactivity, pro-inflammatory cytokines and airway neutrophilia measured. Balb/c mice were sensitized intraperitoneally and challenged intratracheally with house dust mite extract and the effect of either a RORγt inhibitor (BIX119) or an anti-IL-11 antibody assessed on airway hyperreactivity, pro-inflammatory cytokines and airway neutrophilia measured. Results: We confirmed in severe asthma bronchial biopsies both the presence of IL-17-positive lymphocytes and that an IL-17 transcriptome profile in a severe asthma patient sub-population. Both IL-17 and IL-22 stimulated the release of pro-inflammatory cytokine and chemokine release from primary human lung cells and in mice. Furthermore, IL-22 in combination with IL-17, but neither alone, elicits airway hyperresponsiveness (AHR) in naïve mice. A RORγt inhibitor specifically blocked both IL-17 and IL-22, AHR and neutrophilia in a mouse house dust mite model unlike other registered or advanced pipeline modes of action. Full efficacy versus these parameters was associated with 90% inhibition of IL-17 and 50% inhibition of IL-22. In contrast, anti-IL-17 also blocked IL-17, but not IL-22, AHR or neutrophilia. Moreover, the deregulated genes in the lungs from these mice correlated well with deregulated genes from severe asthma biopsies suggesting that this model recapitulates significant severe asthma-relevant biology. Furthermore, these genes were reversed upon RORγt inhibition in the HDM model. Cell deconvolution suggested that the responsible cells were corticosteroid insensitive γδ-T-cells. Conclusion: These data strongly suggest that both IL-17 and IL-22 are required for Th2-low endotype associated biology and that a RORγt inhibitor may provide improved clinical benefit in a severe asthma sub-population of patients by blocking both IL-17 and IL-22 biology compared with blocking IL-17 alone.
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| 5. |
- Leizeaga, Ainara, et al.
(författare)
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Using a tropical elevation gradient to evaluate the impact of land‐use intensity and forest restoration on the microbial use of organic matter under climate change
- 2022
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Ingår i: Global Biogeochemical Cycles. - 0886-6236. ; 36:4
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Tidskriftsartikel (refereegranskat)abstract
- We investigated how legacies of land use and climate affected the microbial use of organic matter (OM) along a tropical climate gradient in Ethiopia. Four levels of land-use intensity ranging from croplands to pristine forests were assessed along a gradient from cool and moist high altitude (MAT = 16°C, MAP = 2,200 mm) to hot and dry lowland sites (MAT = 20°C, MAP = 1,050 mm). We resolved the biomass, structure, and growth rates of microbial decomposer communities together with the rates of carbon (C) and nitrogen (N) transformation. To target the legacies of climate and land use, samples were assessed at optimal moisture and standardized temperature in the laboratory. Microbial biomass and the fungal-to-bacterial ratio increased with both legacies of drier climates and higher land-use intensities. In contrast, fungal growth rates increased in humid climates, but were unaffected by land use. The ratio of C mineralization to gross N mineralization decreased with higher humidity and more intensive land use, suggesting a change in microbial resource use from more nutrient-poor to nutrient-rich OM. Mineralization of nutrient-poor OM implied a lower nutrient availability to microbes in arid climates and low-intensity land uses, while the mineralization of nutrient-rich OM in humid sites and higher intensity land uses implied a higher microbial nutrient availability there. The difference in respiration between land uses increased with ecosystem aridity, suggesting that OM turnover and soil fertility were more impacted by land use in drier climates. Together, our results suggest that drier subtropical climates will exacerbate the negative effects of land-use intensification on OM turnover and nutrient provisioning for plants.
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| 6. |
- Rosinger, Christoph, et al.
(författare)
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Shifts in microbial stoichiometry upon nutrient addition do not capture growth-limiting nutrients for soil microorganisms in two subtropical soils
- 2022
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Ingår i: Biogeochemistry. - : Springer Science and Business Media LLC. - 0168-2563 .- 1573-515X. ; 159:1, s. 33-43
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Tidskriftsartikel (refereegranskat)abstract
- Microbial stoichiometry has become a key aspect in ecological research as shifts in microbial C:N, C:P and N:P ratios upon nutrient addition are presumed to give insight into relative nutrient limitations for soil microorganisms–with far-reaching implications for biogeochemical processes. However, this expectation has never been tested against direct methods of microbial growth responses to nutrient addition. We therefore manipulated a subtropical grassland and forest soil with multifactorial C-, N- and P-additions during 30 days to induce changes in limiting resources and evaluated the resulting soil microbial growth rates, microbial biomass stoichiometry, potential enzyme activities and microbial community composition. Our results show that microbial stoichiometric shifts upon nutrient addition ambiguously predict growth-limiting nutrients for soil microbes. For example, P- and NP-addition to the grassland soil significantly shifted the microbial N:P ratio, which suggests increased N- relative to P-limitation. Microbial growth responses however indicated that soil microbes remained C limited. The same applies for the forest soil, where P-, CN-, NP- and CNP-additions shifted the microbial N:P ratio, yet microbial growth remained C limited. This indicates that microorganisms can immobilize N and P for storage when C is the main limiting nutrient, and that intracellular storage of N and P is responsible for the observed shifts in microbial stoichiometry. Moreover, our data imply that shifts in microbial C:N ratios do not necessarily indicate shifts in microbial community composition and suggest that soil microorganisms–when subject to resource pulses–are stoichiometrically quite plastic.
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| 7. |
- Sandén, Ulrika, et al.
(författare)
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A perspective-taking university course for cancer survivors, loved ones and healthcare professionals
- 2024
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Ingår i: Social Sciences & Humanities Open. - : Elsevier. - 2590-2911. ; 2024:9
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Tidskriftsartikel (refereegranskat)abstract
- This study reports the results of a university course aimed at exploring and improving cooperation in healthcare with both cancer survivors, loved ones and healthcare professionals as students.Central to the course was the understanding of and moving between each other's perspectives. Operating within a framework inspired by problem-based learning (PBL), small groups consisting of at least one cancer survivor, one loved one and one healthcare professional, collaboratively created scenarios based on their personal experiences. The students developed, elaborated, and identified problems and potential solutions. The pedagogical framing illustrated an empowering process of defining and elaborating a problem of their combined concerns, using their different knowledge. Although cooperation presented challenges, most students were able to explore and appreciate each other's perspectives when provided with a safe environment. Our experiences highlight the importance of both contextual safety and personal development as key factors in addressing power imbalances in healthcare.
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| 8. |
- Sandén, Ulrika, et al.
(författare)
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Breaking the patientification process - through co-creation of care, using old arctic survival knowledge
- 2021
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Informa UK Limited. - 1748-2631 .- 1748-2623. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.Method: We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based on four years of observation and 14 interviews. It explains a way of dealing with life close to death and morbidity. In the imminence of danger the studied culture resembles the context of cancer patients. The two following studies used focus group interviews with (b) 19 cancer patients and (c) 17 relatives of cancer patients in southern Sweden.Results: We suggest a process where cancer patients are taught to be submissive and that the support they receive from health providers may be counterproductive to contentment; a patientification process. We present alternative ways for people to handle issues such as hope, waiting, knowledge gaps and healthcare navigation while living with cancer. We introduce an alternative to patientification and passive patients where active patients create their own safety and truly participates in their care. Conclusions: We propose clinical studies to introduce such a shift from patentification to co-creation of care.
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| 9. |
- Scaini, Anna, et al.
(författare)
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Pathways from research to sustainable development: Insights from ten research projects in sustainability and resilience
- 2024
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Ingår i: AMBIO. - : SPRINGER. - 0044-7447 .- 1654-7209.
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on collective experience from ten collaborative research projects focused on the Global South, we identify three major challenges that impede the translation of research on sustainability and resilience into better-informed choices by individuals and policy-makers that in turn can support transformation to a sustainable future. The three challenges comprise: (i) converting knowledge produced during research projects into successful knowledge application; (ii) scaling up knowledge in time when research projects are short-term and potential impacts are long-term; and (iii) scaling up knowledge across space, from local research sites to larger-scale or even global impact. Some potential pathways for funding agencies to overcome these challenges include providing targeted prolonged funding for dissemination and outreach, and facilitating collaboration and coordination across different sites, research teams, and partner organizations. By systematically documenting these challenges, we hope to pave the way for further innovations in the research cycle.
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| 10. |
- Thodelius, Charlotta, et al.
(författare)
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Kriminologiska perspektiv på dödligt skolvåld
- 2021
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Bok (refereegranskat)abstract
- Dödligt skolvåld ingår i serien Kriminologiska perspektiv på ... och belyser svenska händelser av dödligt eller potentiellt dödligt skolvåld. Ger en samlad bild av dödligt skolvåld i Sverige.- Kombinerar rättsligt material och vetenskaplig litteratur.- Kan användas för att belysa likartade händelser, som attacker i köpcentrum eller synagogor. - Visar hur liknande händelser kan förhindras – och hur man kan begränsa följderna när de väl inträffar.Boken är lämplig för utbildning inom exempelvis kriminologi, juridik, psykologi, sociologi och socialt eller polisiärt arbete. Den kan med fördel användas som fortbildning för professionella inom rättsväsende och brottsförebyggande arbete.
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