| 1. |
- Flannagan, Carol A.C., et al.
(författare)
-
Mutual Recognition Methodology Development
- 2015
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Phase 1 of the Mutual Recognition Methodology Development (MRMD) project developed an approach to statistical modeling and analysis of field data to address the state of evidence relevant to mutual recognition of automotive safety regulations. Specifically, the report describes a methodology that can be used to measure evidence for the hypothesis that vehicles meeting EU safety standards would perform similarly to US-regulated vehicles in the US driving environment, and that vehicles meeting US safety standards would perform similarly to EU-regulated vehicles in the EU driving environment. As part of the project, we assessed the availability and contents of crash datasets from the US and the EU, as well as their collective ability to support the proposed statistical methodology.The report describes a set of three statistical approaches to “triangulate” evidence regarding similarity or differences in crash and injury risk associated with EU- and US-regulated vehicles. Approach 1, Seemingly Unrelated Regression, tests whether the models are identical and will also assess the capability of the data analysis to detect differences in the models, if differences exist.Approach 2, Consequences of Best Models, uses logistic regression to develop two separate models, one for EU risk and one for US risk, as a function of a set of predictors (i.e., crash, vehicle, and occupant conditions). The two models will then be exercised on a standard population for the EU and a standard population for the US. Approach 3, Evidence for Consequences, turns the question aroundto measures the overall evidence for each of a set of possible conclusions. Each conclusion is characterized by a range of relative risk on a single population. Evidence is measured using a weighted average of likelihoods for a large group of models that produce the same outcome. That evidence is then compared using Bayes Factors.
|
|
| 2. |
|
|
| 3. |
- Malcus Johnsson, Pia, et al.
(författare)
-
Hand function and performance of daily activities in systemic lupus erythematosus: a clinical study.
- 2015
-
Ingår i: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 24:8, s. 827-834
-
Tidskriftsartikel (refereegranskat)abstract
- This clinical study was performed to investigate hand problems in individuals with systemic lupus erythematosus (SLE) in comparison with healthy controls, and to explore problems in the performance of daily activities related to these hand problems, in order to objectify findings from a previous mail survey. We also investigated whether a simple hand test could detect hand problems in SLE. All individuals, 71 with SLE and 71 healthy controls, were examined for manifestations in body structures and body functions of the hands with a study-specific protocol. The simple hand test was performed by all the individuals and the arthritis impact measurement scale (AIMS 2) questionnaire was completed by the SLE individuals. In the SLE group, 58% had some kind of difficulty in the simple hand test, compared with 8% in the control group. Fifty percent of the SLE individuals experienced problems in performing daily activities due to hand deficits. Pain in the hands, reduced strength and dexterity, Raynaud's phenomenon and trigger finger were the most prominent body functions affecting the performance of daily activities. Deficits in hand function are common in SLE and affect the performance of daily activities. The simple hand test may be a useful tool in detecting hand problems.
|
|
| 4. |
- Mattsson, M., et al.
(författare)
-
Personal factors in systemic sclerosis and their coverage by patient-reported outcome measures
- 2015
-
Ingår i: European Journal of Physical and Rehabilitation Medicine. - 1827-1804. ; 51:4, s. 405-421
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients' background, experience and behavior which highlights the need to know if patient-reported outcome measures (PROMs) include such personal factors. Aim. To identify and describe personal factors in the experiences of functioning and health of persons with SSc and to examine if and to what extent PROMs in SSc research cover these factors. Design. Data from a qualitative study with focus group interviews were analysed. PROMs in SSc research were identified in a literature review between 2008-2013. Setting. Participants were recruited from outpatient clinics at rheumatology department. Population. Sixty-three patients with SSc from four European countries participated. Methods. Data from interviews were analysed using a structure of personal factors developed by Geyh et al. Identified PROMs were analysed and linked to main concepts, related to the personal factors, found in the interview data. Results. Nineteen main concepts were related to the area "patterns of experience and behaviour" in the personal factor structure, 16 to "thoughts and beliefs", nine to "feelings", one to "motives" and one to "personal history and biography", respectively. Among the 35 PROMs identified, 15 did not cover any of the identified concepts. Concepts within the area "feelings" were mostly covered by the PROMs. Five of the PROMs covered "patterns of experience and behaviour", while "motives" and "personal history and biography" were not covered at all. Four of the identified PROMs covered concepts within the areas "feelings", "thoughts and beliefs" and "patterns of experience and behaviour" in the same instrument. The Illness Cognition Questionnaire and Illness Behaviour Questionnaire were such PROMs. Conclusion. Patterns of experience and behaviour had the highest number of concepts related to personal factors, but few of the PROMs in SSc research covered these factors. Only a few PROMs covered several personal factors areas in the same instrument. Clinical Rehabilitation Impact. The results would be of value when developing core sets for outcome measurements in SSc.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Mattsson, Malin, et al.
(författare)
-
Personal factors in systemic sclerosis and their coverage by patient-reported outcome measures : A multicentre European qualitative study and literature review
- 2015
-
Ingår i: European Journal of Physical and Rehabilitation Medicine. - 1973-9087 .- 1973-9095. ; 51:4, s. 405-421
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients’ background, experience and behavior which highlights the need to know if patient-reported outcome measures (PROMs) include such personal factors.AIM: To identify and describe personal factors in the experiences of functioning and health of persons with SSc and to examine if and to what extent PROMs in SSc research cover these factors.DESIGN: Data from a qualitative study with focus group interviews were analysed. PROMs in SSc research were identified in a literature review between 2008-2013.SETTING: Participants were recruited from outpatient clinics at rheumatology department.POPULATION: Sixty-three patients with SSc from four European countries participated.METHODS: Data from interviews were analysed using a structure of personal factors developed by Geyh et al. Identified PROMs were analysed and linked to main concepts, related to the personal factors, found in the interview data.RESULTS: Nineteen main concepts were related to the area “patterns of experience and behaviour” in the personal factor structure, 16 to “thoughts and beliefs”, nine to “feelings”, one to “motives” and one to “personal history and biography”, respectively. Among the 35 PROMs identified, 15 did not cover any of the identified concepts. Concepts within the area “feelings” were mostly covered by the PROMs. Five of the PROMs covered “patterns of experience and behaviour”, while “motives” and “personal history and biography” were not covered at all. Four of the identified PROMs covered concepts within the areas “feelings”, “thoughts and beliefs” and “patterns of experience and behaviour” in the same instrument. The Illness Cognition Questionnaire and Illness Behaviour Questionnaire were such PROMs.CONCLUSION: Patterns of experience and behaviour had the highest number of concepts related to personal factors, but few of the PROMs in SSc research covered these factors. Only a few PROMs covered several personal factors areas in the same instrument.CLINICAL REHABILITATION IMPACT: The results would be of value when developing core sets for outcome measurements in SSc.
|
|
| 9. |
- Sandqvist, G., et al.
(författare)
-
Raynaud’s phenomenon and its impact on activities in daily life during one year of follow-up in early systemic sclerosis
- 2017
-
Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; , s. 1-4
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate Raynaud’s phenomenon (RP) and its impact on daily life activities during 1 year of follow-up in early systemic sclerosis (SSc). Method: Fourteen SSc patients with a median disease duration of 2 years were enrolled in the study. Every 7 weeks the patients completed a 7 day diary documenting the frequency and duration of RP attacks, the activity causing the attack, and how they handled the attack. The patients also recorded in the diary daily self-assessments of the difficulties with RP, using a 0–10 ordinal scale according to the Raynaud’s Condition Score. Results: Ninety-eight RP weekly diaries were analysed. The median number of RP attacks varied between six and nine per week, and the median score reflecting the difficulty associated with the attacks varied between 2.0 and 2.9. No difference was found in the number of attacks or the difficulties associated with them between winter, spring, and autumn. Fewer attacks and less difficulty were reported in August than in any of the other documented weeks (p < 0.05). In all diaries, all patients reported RP attacks associated with domestic activities. The use of heating devices varied during the follow-up. In February, all patients except one used such devices, while about half of the group used devices during the rest of the year. Conclusions: Difficulties resulting from RP are present and disabling all year round, which underscore the importance of intense vasoactive therapy and non-pharmacological strategies throughout the year.
|
|
