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Träfflista för sökning "WFRF:(Sanmartin Agneta) srt2:(1993-1994)"

Sökning: WFRF:(Sanmartin Agneta) > (1993-1994)

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1.
  • Kokaia, Z, et al. (författare)
  • BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage
  • 1994
  • Ingår i: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965 .- 1473-558X. ; 5:10, s. 4-1241
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.
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2.
  • Nikkhah, G, et al. (författare)
  • Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture
  • 1993
  • Ingår i: Experimental Brain Research. - 0014-4819 .- 1432-1106. ; 92:3, s. 516-523
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of two isoforms of platelet-derived growth factor (PDGF), PDGF-AA and PDGF-BB, was tested on dissociated cell cultures of ventral mesencephalon from rat and human embryos. PDGF-BB but not PDGF-AA reduced the progressive loss of tyrosine hydroxylase- (TH)-positive neurons in rat and human cell cultures. The mean number of TH-positive cells in the PDGF-BB-treated rat culture was 64% and 106% higher than in the control cultures after 7 and 10 days in vitro, respectively. Corresponding figures for human TH-positive neurons were 90% and 145%. The influence of PDGF-BB was specific for TH-positive neurons and not a general trophic effect, since no change of either total cell number or metabolic activity was found. In PDGF-BB-treated cultures of human but not rat tissue the TH-positive neurons had longer neurites than observed in control or PDGF-AA-treated cultures. These data indicate that PDGF-BB may act as a trophic factor for mesencephalic dopaminergic neurons and suggest that administration of PDGF-BB could ameliorate degeneration and possibly promote axonal sprouting of these neurons in vivo.
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