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Health-related qual...
Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus
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- Hess, Georg (författare)
- Johannes-Gutenberg University Mainz
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- Rule, Simon (författare)
- Plymouth University
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- Jurczak, Wojciech (författare)
- Jagiellonian University
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- Jerkeman, Mats (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Santucci Silva, Rodrigo (författare)
- Instituto de Ensino e Pesquisa do Hospital São Lucas
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- Rusconi, Chiara (författare)
- Niguarda Hospital
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- Caballero, Dolores (författare)
- University Hospital of Salamanca
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- Joao, Cristina (författare)
- Champalimaud Foundation
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- Witzens-Harig, Mathias (författare)
- University Hospital Heidelberg
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Bence-Bruckler, Isabelle (författare)
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Cho, Seok-Goo (författare)
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- Zhou, Wenjiong (författare)
- Janssen Pharmaceuticals, US
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- Goldberg, Jenna D (författare)
- Janssen Pharmaceuticals, US
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- Trambitas, Cristina (författare)
- Janssen Inc., Canada
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- Enny, Christopher (författare)
- Janssen Pharmaceuticals, US
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- Vermeulen, Jessica (författare)
- Janssen Pharmaceuticals, US
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- Traina, Shana (författare)
- Janssen Pharmaceuticals, US
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- Chiou, Chiun Fang (författare)
- Janssen Pharmaceuticals, US
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- Diels, Joris (författare)
- Janssen Pharmaceutica
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- Dreyling, Martin (författare)
- University Hospital Munich
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(creator_code:org_t)
- 2017-05-30
- 2017
- Engelska.
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 58:12, s. 2824-2832
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mantle cell lymphoma (MCL) is a rare, aggressive, incurable B-cell malignancy. Ibrutinib has been shown to be highly active for patients with relapsed/refractory (R/R) MCL. The RAY trial (MCL3001) was a phase 3, randomized, open-label, multicenter study that compared ibrutinib with temsirolimus in patients with R/R MCL. Active disease is frequently associated with impaired functional status and reduced well-being. Therefore, the current study employed two patient-reported outcome instruments, the Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym) and the EQ-5D-5L, to assess symptoms, well-being, health status, and health-related quality of life of patients on treatment within the RAY trial. We found that patients on ibrutinib had substantial improvement in FACT-Lym subscale and total scores, and had improvement in EQ-5D-5L utility and VAS scores compared with temsirolimus patients, indicating a superior well-being. These improvements in well-being correlated with clinical response, indicating that better health-related quality of life was associated with decreased disease burden.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Bruton’s tyrosine kinase inhibitor
- EQ-5D-5L
- FACT-Lym
- ibrutinib
- mantle cell lymphoma
- patient-reported outcomes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Hess, Georg
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Rule, Simon
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Jurczak, Wojciec ...
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Jerkeman, Mats
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Santucci Silva, ...
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Rusconi, Chiara
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visa fler...
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Caballero, Dolor ...
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Joao, Cristina
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Witzens-Harig, M ...
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Bence-Bruckler, ...
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Cho, Seok-Goo
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Zhou, Wenjiong
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Goldberg, Jenna ...
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Trambitas, Crist ...
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Enny, Christophe ...
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Vermeulen, Jessi ...
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Traina, Shana
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Chiou, Chiun Fan ...
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Diels, Joris
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Dreyling, Martin
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