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A European multicen...
A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists
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- Rizos, A. (author)
- King's College Hospital
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- Sauerbier, A. (author)
- King's College London
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- Antonini, A. (author)
- University of Padova
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- Weintraub, D. (author)
- University of Pennsylvania
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- Martinez-Martin, P. (author)
- Carlos III Health Institute
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- Kessel, B. (author)
- King's College Hospital
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- Henriksen, T. (author)
- Bispebjerg Hospital
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- Falup-Pecurariu, C. (author)
- Transylvania University Brasov
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- Silverdale, M. (author)
- Salford Royal NHS Foundation Trust
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- Durner, G. (author)
- King's College Hospital
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- Røkenes Karlsen, K. (author)
- King's College Hospital
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- Grilo, M. (author)
- King's College Hospital
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- Odin, P. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Central Hospital Bremerhaven
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- Chaudhuri, K. Ray (author)
- University Hospital Lewisham
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(creator_code:org_t)
- 2016-05-11
- 2016
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101. ; 23:8, s. 1255-1261
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Abstract
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- Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. Methods: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal) across a broad range of disease stages and age groups was performed. Results: Four hundred and twenty-five cases were included [mean age 68.3 years (range 37-90), mean duration of disease 7.5 years (range 0-37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P <0.05) compared with any other assessed DAs except for prolonged release PPX (PPX-PR). The rate of ICDs for PPX-PR (6.6%) was significantly lower than for immediate release PPX (PPX-IR) (19.0%; P <0.05). Discontinuation rates of DA therapy due to ICDs were low. Conclusion: Our data suggest a relatively low rate of ICDs with long-acting or transdermal DAs, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Dopamine agonists
- Dopamine dysregulation syndrome
- Impulse control behaviours/disorders
- Parkinson's disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Rizos, A.
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Sauerbier, A.
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Antonini, A.
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Weintraub, D.
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Martinez-Martin, ...
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Kessel, B.
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show more...
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Henriksen, T.
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Falup-Pecurariu, ...
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Silverdale, M.
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Durner, G.
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Røkenes Karlsen, ...
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Grilo, M.
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Odin, P.
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Chaudhuri, K. Ra ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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European Journal ...
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Lund University