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β-Amyloid and tau b...
β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies
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- Ferreira, Daniel (författare)
- Karolinska Institutet,Karolinska Institute,Mayo Clinic Minnesota
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- Przybelski, Scott A. (författare)
- Mayo Clinic Minnesota
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- Lesnick, Timothy G. (författare)
- Mayo Clinic Minnesota
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- Lemstra, Afina W. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Londos, Elisabet (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Blanc, Frederic (författare)
- University Hospital Of Strasbourg,University of Strasbourg
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- Nedelska, Zuzana (författare)
- Mayo Clinic Minnesota
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- Schwarz, Christopher G. (författare)
- Mayo Clinic Minnesota
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- Graff-Radford, Jonathan (författare)
- Mayo Clinic Minnesota
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- Senjem, Matthew L. (författare)
- Mayo Clinic Minnesota
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- Fields, Julie A. (författare)
- Mayo Clinic Minnesota
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- Knopman, David S. (författare)
- Mayo Clinic Minnesota
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- Savica, Rodolfo (författare)
- Mayo Clinic Minnesota
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- Ferman, Tanis J. (författare)
- Mayo Clinic Minnesota
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- Graff-Radford, Neill R. (författare)
- Mayo Clinic Minnesota
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- Lowe, Val J. (författare)
- Mayo Clinic Minnesota
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- Jack, Clifford R. (författare)
- Mayo Clinic Minnesota
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- Petersen, Ronald C. (författare)
- Mayo Clinic Minnesota
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- Mollenhauer, Brit (författare)
- Paracelsus-Elena-Klinik Kassel,University of Göttingen
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- Garcia-Ptacek, Sara (författare)
- Karolinska Institutet,Karolinska Institute
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- Abdelnour, Carla (författare)
- Barcelona Alzheimer Treatment & Research Center
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- Hort, Jakub (författare)
- St. Anne's University Hospital Brno
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- Bonanni, Laura (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Oppedal, Ketil (författare)
- Stavanger University Hospital,University of Stavanger
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- Kramberger, Milica G. (författare)
- University Medical Centre Ljubljana,University of Ljubljana
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- Boeve, Bradley F. (författare)
- Mayo Clinic Minnesota
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- Aarsland, Dag (författare)
- Karolinska Institutet
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- Westman, Eric (författare)
- Karolinska Institutet,Karolinska Institute
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- Kantarci, Kejal (författare)
- Mayo Clinic Minnesota
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(creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Neurology. - 1526-632X. ; 95:24, s. 3257-3268
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+) and tau (T+) biomarkers was determined by CSF β-amyloid1-42 and phosphorylated tau in the European cohort and by Pittsburgh compound B and AV-1451 PET in the Mayo Clinic cohort. Patients were stratified into 4 groups: A-T-, A+T-, A-T+, and A+T+. RESULTS: A-T- was the largest group (39%), followed by A+T- (32%), A+T+ (15%), and A-T+ (13%). The percentage of A-T- decreased with age, and A+ and T+ increased with age in both women and men. A+ increased more in APOE ε4 carriers with age than in noncarriers. A+ was the main predictor of lower cognitive performance when considered together with T+. T+ was associated with a lower frequency of parkinsonism and probable REM sleep behavior disorder. There were no significant interactions between A+ and T+ in relation to the clinical phenotype. CONCLUSIONS: Alzheimer disease pathologic changes are common in DLB and are associated with the clinical phenotype. β-Amyloid is associated with cognitive impairment, and tau pathology is associated with lower frequency of clinical features of DLB. These findings have important implications for diagnosis, prognosis, and disease monitoring, as well as for clinical trials targeting disease-specific proteins in DLB. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with probable DLB, β-amyloid is associated with lower cognitive performance and tau pathology is associated with lower frequency of clinical features of DLB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- Av författaren/redakt...
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Ferreira, Daniel
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Przybelski, Scot ...
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Lesnick, Timothy ...
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Lemstra, Afina W ...
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Londos, Elisabet
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Blanc, Frederic
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visa fler...
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Nedelska, Zuzana
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Schwarz, Christo ...
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Graff-Radford, J ...
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Senjem, Matthew ...
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Fields, Julie A.
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Knopman, David S ...
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Savica, Rodolfo
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Ferman, Tanis J.
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Graff-Radford, N ...
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Lowe, Val J.
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Jack, Clifford R ...
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Petersen, Ronald ...
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Mollenhauer, Bri ...
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Garcia-Ptacek, S ...
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Abdelnour, Carla
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Hort, Jakub
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Bonanni, Laura
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Oppedal, Ketil
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Kramberger, Mili ...
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Boeve, Bradley F ...
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Aarsland, Dag
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Westman, Eric
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Kantarci, Kejal
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Neurology
- Av lärosätet
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Lunds universitet
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Karolinska Institutet