| 1. |
- Yoo, S. J. B., et al.
(författare)
-
Spectral phase encoded time spread optical code division multiple access technology for next generation communication networks Invited
- 2007
-
Ingår i: Journal of Optical Networking. - 1536-5379. ; 6:10, s. 1210-1227
-
Tidskriftsartikel (refereegranskat)abstract
- We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/s (32-user x 10 Gbit/s) all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral efficiency at 100% and above. In particular, InP-based integrated photonics allows implementation of SPECTS O-CDMA transmitters and receivers monolithically integrated on a chip. The integrated InP chip technology not only allows robust and compact configurations for practical and low-cost O-CDMA network deployments but also offers code reconfigurations at rapid rates for secure communication applications.
|
|
| 2. |
- Ding, Li, et al.
(författare)
-
Somatic mutations affect key pathways in lung adenocarcinoma
- 2008
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 455:7216, s. 1069-1075
-
Tidskriftsartikel (refereegranskat)abstract
- Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
|
|
| 3. |
- Birney, Ewan, et al.
(författare)
-
Prepublication data sharing
- 2009
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 461:7261, s. 168-170
-
Tidskriftsartikel (refereegranskat)abstract
- Rapid release of prepublication data has served the field of genomics well. Attendees at a workshop in Toronto recommend extending the practice to other biological data sets.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Broeke, Ronald G., et al.
(författare)
-
Optical-CDMA in InP
- 2007
-
Ingår i: IEEE Journal of Selected Topics in Quantum Electronics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1077-260X .- 1558-4542. ; 13:5, s. 1497-1507
-
Tidskriftsartikel (refereegranskat)abstract
- This paper describes the InP platforms for photonic integration and the development on these platforms of an optical code division multiple access (O-CDMA) system for local area networks. We demonstrate three building blocks of this system: an optical pulse source, an encoder/decoder pair, and a threshold detector. The optical pulse source consists of an integrated colliding pulse-mode laser with nearly transform-limited 10 Gb/s pulses and optical injection locking to an external clock for synchronization. The encoder/decoder pair is based on arrayed waveguide gratings. Bit-error-rate measurements involving six users at 10 Gb/s showed error-free transmission, while O-CDMA codes were calibrated using frequency resolved optical gating. For threshold detection after the decoder, we compared two Mach-Zehnder interferometer (MZI)-based optical thresholding schemes and present results on a new type of electroabsorber-based MZI.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Flykt, Anders, et al.
(författare)
-
Using a probe detection task to assess the timing of intrinsic pleasantness appraisals
- 2009
-
Ingår i: Swiss Journal of Psychology. - : Hogrefe Publishing Group. - 1421-0185 .- 1662-0879. ; 68:3, s. 161-171
-
Tidskriftsartikel (refereegranskat)abstract
- The occurrence and timing of emotion-antecedent appraisal checks are difficult to assess. We report an attempt to estimate the time window of the intrinsic pleasantness check using a dual-task probe paradigm. In three experiments, participants viewed negative and positive pictures. Their other task was speeded response on a probe superimposed on the pictures with different stimulus onset asynchronies (SOAs). Longer probe-reaction times were observed for negative than for positive pictures. This effect appeared at SOA 300 ms or 350 ms, suggesting that the intrinsic pleasantness appraisal check yields a differential behavioral outcome around 300 ms after stimulus onset, and seems to continue unless attention to picture content is inhibited. This paradigm might be successfully used for the mental chronography of appraisal processes.
|
|
