| 1. |
- Uy, G. L., et al.
(författare)
-
Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation
- 2015
-
Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 50:12, s. 1513-1518
-
Tidskriftsartikel (refereegranskat)abstract
- In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). It is uncertain whether the method of mobilization affects post-transplant outcomes. We compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-Ha in the US and Canada between 2007 and 2012. The kinetics of neutrophil engraftment (>= 0.5 x 10(9)/L) was similar between groups (13 vs 13 days, P=0.69) while platelet engraftment (>= 20 x 10(9)/L) was slightly faster with CC+GF (19 vs 18 days, P=0.006). Adjusted 3-year PFS was 43% (95% confidence interval (CI) 38-48) in GF and 40% (95% CI 35-45) in CC+GF, P=0.33. Adjusted 3-year OS was 82% (95% CI 78-86) vs 80% (95% CI 75-84), P=0.43 and adjusted 5-year OS was 62% (95% CI 54-68) vs 60% (95% CI 52-67), P=0.76, for GF and CC+GF, respectively. We conclude that MM patients undergoing auto-Ha have similar outcomes irrespective of the method of mobilization and found no evidence that the addition of chemotherapy to mobilization contributes to disease control.
|
|
| 2. |
- Gu, Y, et al.
(författare)
-
Quick Hot Shot & Young Surgeon Presentation
- 2015
-
Ingår i: Hernia : the journal of hernias and abdominal wall surgery. - 1248-9204. ; 19 Suppl 1, s. S77-84
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Bejanyan, Nelli, et al.
(författare)
-
Pretransplant Consolidation Is Not Beneficial for Adults with ALL Undergoing Myeloablative Allogeneic Transplantation
- 2018
-
Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 24:5, s. 945-955
-
Tidskriftsartikel (refereegranskat)abstract
- Allogeneic hematopoietic cell transplantation (alloHCT) is curative for patients with acute lymphoblastic leukemia (ALL) who achieve complete remission (CR1) with chemotherapy. However, the benefit of consolidation chemotherapy remains uncertain in patients undergoing alloHCT. We compared clinical outcomes of 524 adult patients with ALL in CR1 who received ≥2 (n = 109), 1 (n = 93), or 0 cycles (n = 322) of consolidation before myeloablative alloHCT from 2008 to 2012. As expected, time to alloHCT was longer with increasing cycles of consolidation. Patients receiving ≥2, 1, or 0 cycles of consolidation had an adjusted 3-year cumulative incidence of relapse of 20%, 27%, and 22%; 1-year transplant-related mortality (TRM) of 16%, 18%, and 23%; adjusted 3-year leukemia-free survival (LFS) of 54%, 48%, and 47%; and 3-year overall survival (OS) of 63%, 59%, and 54% (all P values >.40). Multivariable analysis confirmed that consolidation was not prognostic for LFS (relative risk, 1.20, 95% confidence interval, .86 to 1.67; P = .28 for no consolidation; RR, 1.18, 95% confidence interval, .79 to 1.76; P = .41 for 1 cycle versus ≥2 cycles = reference). Similarly, consolidation was not associated with OS, relapse, TRM, or graft-versus-host disease. We conclude that consolidation chemotherapy does not appear to provide added benefit in adult ALL patients with available donors who undergo myeloablative alloHCT in CR1.
|
|
| 4. |
- Cartier, Rosine, et al.
(författare)
-
Hydrological changes in Yellowstone Lake (USA) during the Holocene based on the analysis of oxygen isotopes in diatoms
- 2019
-
Ingår i: Hydrological changes in Yellowstone Lake (USA) during the Holocene based on the analysis of oxygen isotopes in diatoms.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Northern Yellowstone Lake is on the southeast edge of the 631-ka Yellowstone caldera and is an area with high heat flow, high seismicity, and an abundance of active hydrothermal features and structures. Several large hydrothermal explosions since the last glacial recession formed craters of more than 100 m in diameter. These large craters raise the question on how climate and hydrological changes have affected the hydrothermal system and the lake ecosystem at millennial timescales.This study focuses on an 11.6-m-long core collected in 2016 in the Lake Hotel graben covering the last 9,900 cal years according to radiocarbon ages. Past hydrological changes were inferred from oxygen isotopes values of biogenic silica that comprises the cell wall of the diatoms. d 18O values reflect silica-lake water fractionation during diatom growth. The d 18O values vary according to changes in sources of precipitation, supply of runoff by tributaries, lake water temperature, and evaporation. Currently, precipitation occurs mainly as winter snow from weather systems originating in the Pacific.Periods of high d 18O in diatoms (enrichment in the heavy isotope) occur from the base of the record 9900 to ca. 7500 cal years BP, from 4500 to 3000 cal years BP and ca. 1000 cal years BP. These isotopic enrichments have been interpreted as to be mostly the result of increased water evaporation and/or reduced snowmelt flowing into the lake from the Yellowstone River and other tributaries. This inference is supported by d 18O measurements from water samples showing that lake water is progressively more evaporated with increased distance from the Yellowstone River inlet . The base of the record also is characterized by lower abundance of Pinus pollen suggesting a more open Pinus contorta forest until 5800 cal years BP, with more-frequent fire than today. Additionally, a long-term decrease in d 18Odiatomin the record and a progressive increase in the duration of spring water mixing shown by diatom assemblages (i.e. higher A. subarctica/S. minutulusratio) are associated with decreased summer insolation during the Holocene. These results compare well with other paleoclimatic records from the Yellowstone region that show a transition to cool, wet conditions in the late Holocene.
|
|
| 5. |
|
|
| 6. |
- Mahindra, Anuj, et al.
(författare)
-
New Cancers after Autotransplantations for Multiple Myeloma
- 2015
-
Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 21:4, s. 738-745
-
Tidskriftsartikel (refereegranskat)abstract
- We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7 years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P = .0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.
|
|
| 7. |
- Schiller, Bernt, 1934, et al.
(författare)
-
“The Nordic model”: historical origins and its significance for the work place dialogue towards increased organizational sustainability
- 2017
-
Ingår i: Dellve L., Wikström E., Björk L., Wolmesjö M., Larsson Fällmanand S. (Eds.) Abstract book of the 11th NOVO symposium. Gothenburg: 9-10 November. - Gothenburg : Gothenburg University. - 9789187876172
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The vision of the NOVO network is “a Nordic Model for development of more sustainable production systems in healthcare”. It is based on the assumption that the Nordic countries, through high levels of trust and justice (social capital), have unique opportunities to carry out dialogue-based change processes, cf. “the Nordic Model”. This seems important due to the frequent negative impact of rationalization on ergonomics and vice versa (see previous abstract by Winkel et al). The Nordic model has been the subject of extensive discussions and studies (e.g. Schiller et al., 1993). The Nordic exceptionalism might first be noticeable in the Middle Ages in the weak feudalism compared to the Continent. The peasants of the North were personally free and owned their land. They paid taxes and were the direct subjects of the Crown. Correspondingly, the nobility was weak. At the time of the industrial breakthrough in the 19th century, industrial workers were recruited from the landless, often sons and daughters of self-owning farmers. Before the advent of the labour movement, dialogue instead of violence was the trusted way for the popular movements to advance their cause. The international revolutionary orientation of the trade unions was already during the 1890s subordinated to negotiations with national employers. The collective agreement is the counterpart to the share contract (in Danish: “Andelskontrakt”), which created and structured social capital in the agricultural development in Denmark. The collective agreement also begun its successful spread in Denmark and became dominant in the whole of the North. The class conflicts took place in countries without major ethnic, cultural and religious splits. In a European comparison class differences were relative moderate. The state had a limited record of active repression and corruption. To-day we still have the best organized trade unions in the world, close cooperation with important social democratic parties, strong employer organizations, early recognition of trade unions and established policy of collective bargaining with close to total coverage of the labour market and a principle of no-state intervention in industrial conflicts. Thus, the industrial relations in the Nordic countries still seem to be exceptional. Key research issues are now to further investigate the Nordic Model in terms of: - critical prerequisites for a positive environment for dialogues based on workplace agreements, - how such insights can be measured and further developed, - how they can be made available to a wider audience in an applicable way
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
