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Träfflista för sökning "WFRF:(Schleede Simone) srt2:(2012)"

Sökning: WFRF:(Schleede Simone) > (2012)

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1.
  • Schleede, Simone, et al. (författare)
  • Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
  • 2012
  • Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 109:44, s. 17880-17885
  • Tidskriftsartikel (refereegranskat)abstract
    • In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
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2.
  • Schleede, Simone, et al. (författare)
  • Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source
  • 2012
  • Ingår i: Journal of Synchrotron Radiation. - 1600-5775. ; 19, s. 525-529
  • Tidskriftsartikel (refereegranskat)abstract
    • The Compact Light Source is a miniature synchrotron producing X-rays at the interaction point of a counter-propagating laser pulse and electron bunch through the process of inverse Compton scattering. The small transverse size of the luminous region yields a highly coherent beam with an angular divergence of a few milliradians. The intrinsic monochromaticity and coherence of the produced X-rays can be exploited in high-sensitivity differential phase-contrast imaging with a grating-based interferometer. Here, the first multimodal X-ray imaging experiments at the Compact Light Source at a clinically compatible X-ray energy of 21 keV are reported. Dose-compatible measurements of a mammography phantom clearly demonstrate an increase in contrast attainable through differential phase and dark-field imaging over conventional attenuation-based projections.
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