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Long-term risk of r...
Long-term risk of recurrent vascular events and mortality in young stroke patients: Insights from a multicenter study
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Broman, J. (author)
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Fandler-Hofler, S. (author)
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von Sarnowski, B. (author)
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Elmegiri, M. (author)
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Gattringer, T. (author)
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Holbe, C. (author)
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von der Linden, J. (author)
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Malinowski, R. (author)
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Martola, J. (author)
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Pinter, D. (author)
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Ropele, S. (author)
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Schminke, U. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Enzinger, C. (author)
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Putaala, J. (author)
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Aarnio, K. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: European Journal of Neurology. - 1351-5101. ; 30:9, s. 2675-2683
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Although the incidence of stroke in the young is rising, data on long-term outcomes in these patients are scarce. We thus aimed to investigate the long-term risk of recurrent vascular events and mortality in a multicenter study. Methods: We followed 396 consecutive patients aged 18-55 years with ischemic stroke (IS) or transient ischemic attack (TIA) enrolled in three European centers during the period 2007-2010. A detailed outpatient clinical follow-up assessment was performed between 2018 and 2020. When an in-person follow- -up visit was not possible, outcome events were assessed using electronic records and registry data. Results: During a median follow-up of 11.8 (IQR 10.4-12.7) years, 89 (22.5%) patients experienced any recurrent vascular event, 62 (15.7%) had any cerebrovascular event, 34 (8.6%) had other vascular events, and 27 (6.8%) patients died. Cumulative 10-year incidence rate per 1000 person-years was 21.6 (95% CI 17.1-26.9) for any recurrent vascular event and 14.9 (95% CI 11.3-19.3) for any cerebrovascular event. The prevalence of cardiovascular risk factors increased over time, and 22 (13.5%) patients lacked any secondary preventive medication at the in-person follow-up. After adjustment for demographics and comorbidities, atrial fibrillation at baseline was found to be significantly associated with recurrent vascular events. Conclusions: This multicenter study shows a considerable risk of recurrent vascular events in young IS and TIA patients. Further studies should investigate whether detailed individual risk assessment, modern secondary preventive strategies, and better patient adherence may reduce recurrence risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- long-term follow-up
- mortality
- prognosis
- recurrent vascular events
- young stroke
- ischemic-stroke
- adults
- 1st-ever
- classification
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Broman, J.
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Fandler-Hofler, ...
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von Sarnowski, B ...
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Elmegiri, M.
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Gattringer, T.
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Holbe, C.
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show more...
-
von der Linden, ...
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Malinowski, R.
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Martola, J.
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Pinter, D.
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Ropele, S.
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Schminke, U.
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Tatlisumak, Turg ...
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Enzinger, C.
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Putaala, J.
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Aarnio, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg