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Genome-Wide Interac...
Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk
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- Tian, Yu (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
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- Kim, Andre E. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Bien, Stephanie A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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visa fler...
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Carreras-Torres, Robert (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Díez-Obrero, Virginia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Dimou, Niki (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Drew, David A. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Hidaka, Akihisa (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Huyghe, Jeroen R. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Jordahl, Kristina M. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Morrison, John (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Obón-Santacana, Mireia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Ulrich, Cornelia M. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Ose, Jennifer (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Peoples, Anita R. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Ruiz-Narvaez, Edward A. (författare)
- Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
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- Shcherbina, Anna (författare)
- Biomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States
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- Stern, Mariana C. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Su, Yu-Ru (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
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- van Duijnhoven, Franzel J B (författare)
- Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Baurley, James W. (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Bishop, D Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
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- Chan, Andrew T. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Gallinger, Steven (författare)
- Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
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- Gruber, Stephen B. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
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- Joshi, Amit D. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi
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- Le Marchand, Loic (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Giles, Graham G. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Milne, Roger L. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Nan, Hongmei (författare)
- Department of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
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- Ogino, Shuji (författare)
- Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
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- Budiarto, Arif (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Potter, John D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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- Prentice, Ross L. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Rennert, Gad (författare)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Schoen, Robert E. (författare)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Thibodeau, Stephen N. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi
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- Woods, Michael O. (författare)
- Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada
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- Wu, Anna H. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Campbell, Peter T. (författare)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Casey, Graham (författare)
- Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
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- Conti, David V. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Kundaje, Anshul (författare)
- Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Lewinger, Juan Pablo (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Moreno, Victor (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Pardamean, Bens (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Thomas, Duncan C. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Tsilidis, Konstantinos K. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Gauderman, W James (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
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(creator_code:org_t)
- 2022-05-05
- 2022
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 114:8, s. 1135-1148
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. METHODS: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants. RESULTS: The use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P < 1.2 × 10-4). CONCLUSION: Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Tian, Yu
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Kim, Andre E.
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Bien, Stephanie ...
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Lin, Yi
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Qu, Conghui
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Harrison, Tabith ...
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visa fler...
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Carreras-Torres, ...
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Díez-Obrero, Vir ...
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Dimou, Niki
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Drew, David A.
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Hidaka, Akihisa
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Huyghe, Jeroen R ...
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Jordahl, Kristin ...
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Morrison, John
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Murphy, Neil
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Obón-Santacana, ...
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Ulrich, Cornelia ...
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Ose, Jennifer
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Peoples, Anita R ...
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Ruiz-Narvaez, Ed ...
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Shcherbina, Anna
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Stern, Mariana C ...
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Su, Yu-Ru
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van Duijnhoven, ...
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Arndt, Volker
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Baurley, James W ...
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Berndt, Sonja I.
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Bishop, D Timoth ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Chan, Andrew T.
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Gruber, Stephen ...
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Harlid, Sophia, ...
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Hoffmeister, Mic ...
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Jenkins, Mark A.
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Joshi, Amit D.
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Keku, Temitope O ...
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Larsson, Susanna ...
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Le Marchand, Loi ...
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Li, Li
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Giles, Graham G.
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Milne, Roger L.
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Nan, Hongmei
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Nassir, Rami
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Ogino, Shuji
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Budiarto, Arif
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Platz, Elizabeth ...
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Potter, John D.
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Prentice, Ross L ...
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Rennert, Gad
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Sakoda, Lori C.
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Schoen, Robert E ...
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Slattery, Martha ...
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Thibodeau, Steph ...
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van Guelpen, Bet ...
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Visvanathan, Kal ...
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Campbell, Peter ...
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Casey, Graham
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Conti, David V.
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Gunter, Marc J.
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Kundaje, Anshul
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Lewinger, Juan P ...
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Moreno, Victor
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Newcomb, Polly A ...
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Pardamean, Bens
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Thomas, Duncan C ...
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Tsilidis, Konsta ...
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Peters, Ulrike
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Gauderman, W Jam ...
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Hsu, Li
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Chang-Claude, Je ...
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