| 1. |
- Horvath, Rita, et al.
(författare)
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Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy.
- 2009
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Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 132:Pt 11, s. 3165-74
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Tidskriftsartikel (refereegranskat)abstract
- Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling infantile disorder, long known as 'benign cytochrome c oxidase deficiency myopathy' is an exception because it shows spontaneous recovery if infants survive the first months of life. Current investigations cannot distinguish those with a good prognosis from those with terminal disease, making it very difficult to decide when to continue intensive supportive care. Here we define the principal molecular basis of the disorder by identifying a maternally inherited, homoplasmic m.14674T>C mt-tRNA(Glu) mutation in 17 patients from 12 families. Our results provide functional evidence for the pathogenicity of the mutation and show that tissue-specific mechanisms downstream of tRNA(Glu) may explain the spontaneous recovery. This study provides the rationale for a simple genetic test to identify infants with mitochondrial myopathy and good prognosis.
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| 2. |
- Kruse, S.A., et al.
(författare)
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Socioeconomic indicators as a complement to life cycle assessment : An application to salmon production systems
- 2009
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Ingår i: The International Journal of Life Cycle Assessment. - : Springer Science and Business Media LLC. - 0948-3349 .- 1614-7502. ; 14:1, s. 42234-
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Tidskriftsartikel (refereegranskat)abstract
- Background, aim, and scope: There is a growing recognition on the part of industry, policymakers, and consumers that sustainable industry practices are needed to maintain environmental and social well being. Life cycle assessment (LCA) is an internationally standardized analytical framework that has traditionally focused on evaluation of the environmental impacts of processes or products using a cradle-to-grave approach. Yet, sustainability, defined generally, requires that assessments consider not only environmental but also social and economic impacts-the other two pillars of sustainability. Even though the LCA methodology has the potential to include both social and economic indicators, and SETAC guidelines recommend the inclusion of such impact categories in all detailed LCAs, no established set of metrics exists to describe the relationship between socioeconomic indicators (SEIs) and a specific product or process; nor is there a common understanding on how such metrics might be developed. This article presents the methods for and development of a suite of socioeconomic indicators that complement the LCA methodology and provides a comprehensive approach for assessing the cradle-to-grave sustainability of a product or process. Methods: A combined top-down and bottom-up approach serves as the basis for development of the set of socioeconomic indicators presented here. Generally recognized societal values, industry specific issues, and financial constraints associated with collection of data necessary for measurement of the indicators are all factors considered in this approach. In our categorization, socioeconomic indicators fall into two types: additive indicators and descriptive indicators. Results: Indicators are categorized based on fundamental methodological differences and then used to describe the socioeconomic impacts associated with salmon production. Additive indicators (e.g., production costs and value added) and descriptive indicators (e.g., fair wage and contribution to personal income) are both discussed. Discussion: There is a need to further develop and refine methods to assess the results of socioeconomic indicators using a life cycle perspective. It would be most interesting to conduct additional case studies that focus on such methodological development, particularly trade-offs between stakeholder groups and pillars of sustainability. Additional areas of discussion are (1) the need for data to populate socioeconomic indicators and (2) defining system boundaries for socioeconomic indicators. Conclusions: This article presents a set of socioeconomic indicators designed to serve as a complement for the LCA framework, thus, increasing the framework's effectiveness as a measure of the overall sustainability of a product or process. Development of socioeconomic indicators as a complement to LCA is still in its early stages, however, and further research is required. Recommendations and perspectives: The SEIs presented here are discussed theoretically within the context of salmon food production systems, but a test of the practicability and validity of the indicators (i.e., a practical application) is also necessary. The practical application of the topic will be presented in a forthcoming paper. © 2008 Springer-Verlag.
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| 3. |
- Verdorfer, I., et al.
(författare)
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Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in mucoepidermoid carcinomas of the salivary gland.
- 2009
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Ingår i: Oncology reports. - 1021-335X. ; 22:2, s. 305-11
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine genetic alterations in mucoepidermoid carcinomas of the salivary gland in association with clinical and histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors were analysed by using comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH) on interphase nuclei and reverse transcriptase-polymerase chain reaction (RT-PCR) for detection of MECT1-MAML2 fusion transcript. The CGH analysis showed an overrepresentation of chromosome X and losses of entire chromosomes or regions on chromosome 1, 2, and 15 as the most frequent copy number changes. In 37% of the analysed tumors a MAML2-rearrangement by interphase FISH was detected, whereas 58% of the samples showed expression of MECT1-MAML2 fusion transcript. We conclude that the presence of MAML2-rearrangement as well as of MECT1-MAML2 fusion transcript may reflect a more favourable prognosis and may be a useful marker for clinical prediction of the biological behavior of these tumors as previously reported.
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| 4. |
- Ayer, N.W., et al.
(författare)
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Co-product allocation in life cycle assessments of seafood production systems : Review of problems and strategies
- 2007
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Ingår i: The International Journal of Life Cycle Assessment. - : Springer Science and Business Media LLC. - 0948-3349 .- 1614-7502. ; 12:7, s. 480-487
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Tidskriftsartikel (refereegranskat)abstract
- Background, Aim and Scope. As Life Cycle Assessment is being increasingly applied to study fisheries and aquaculture systems, the LCA methodology must be adapted to address the unique aspects of these systems. The focus of this methodological paper is the specific allocation problems faced in studying seafood production systems and how they have been addressed to date. Main Features. The paper begins with a literature review of existing LCA research of fishing and aquaculture systems with a specific focus on 1) identifying the key allocation problems; 2) describing the choice of allocation procedures; and 3) providing insight on the rationale for those choices where available. The allocation procedures are then discussed in the context of ISO recommendations and other published guidance on allocation, followed by a discussion of the key lessons to be learned from the reviewed studies and recommendations for future LCAs of seafood production systems. Literature Review. The literature review suggests that allocation problems are most likely to arise when dealing with: landed by-catch within the context of capture fisheries, the use of co-product feed ingredients in aquaculture feeds, multiple outputs from fish farms, and the generation of by-products when seafood is processed. System expansion and allocation according to physical causality were not applied in most cases, while economic allocation was the most widely used approach. It was also observed that the level of detail and justification provided for allocation decisions in most published reports was inconsistent and incomplete. Discussion. The results of this literature review are consistent with other reviews of allocation in LCA in that allocation according to economic value was found to be the most frequently applied approach. The application of economic allocation when system expansion is not feasible is consistent with ISO guidance. However, economic allocation is not the most appropriate method in seafood production LCAs because it does not reflect the biophysical flows of material and energy between the inputs and outputs of the production system. Conclusions, Recommendations and Perspectives. More effort needs to be invested in developing allocation procedures appropriate to seafood production systems. Allocation based on gross energy content is proposed as one potential alternative means of allocating environmental burdens in some instances in seafood production LCAs. A standard set of requirements for how to describe and justify allocation decisions in published reports is needed to make these studies more robust and transparent. © 2007 ecorried publishers (Verlagsgruppe Hüthig Jehle Rehm GmbH).
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| 5. |
- Darakchieva, Vanya, 1971-, et al.
(författare)
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Anisotropic strain and phonon deformation potentials in GaN
- 2007
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 75:19, s. 195217-
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Tidskriftsartikel (refereegranskat)abstract
- We report optical phonon frequency studies in anisotropically strained c -plane- and a -plane-oriented GaN films by generalized infrared spectroscopic ellipsometry and Raman scattering spectroscopy. The anisotropic strain in the films is obtained from high-resolution x-ray diffraction measurements. Experimental evidence for splitting of the GaN E1 (TO), E1 (LO), and E2 phonons under anisotropic strain in the basal plane is presented, and their phonon deformation potentials c E1 (TO), c E1 (LO), and c E2 are determined. A distinct correlation between anisotropic strain and the A1 (TO) and E1 (LO) frequencies of a -plane GaN films reveals the a A1 (TO), b A1 (TO), a E1 (LO), and b E1 (LO) phonon deformation potentials. The a A1 (TO) and b A1 (TO) are found to be in very good agreement with previous results from Raman experiments. Our a A1 (TO) and a E1 (LO) phonon deformation potentials agree well with recently reported theoretical estimations, while b A1 (TO) and b E1 (LO) are found to be significantly larger than the theoretical values. A discussion of the observed differences is presented. © 2007 The American Physical Society.
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| 6. |
- Hernandez, Victor Agmo, et al.
(författare)
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The adhesion and spreading of thrombocyte vesicles on electrode surfaces
- 2008
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Ingår i: Bioelectrochemistry. - : Elsevier BV. - 1567-5394 .- 1878-562X. ; 74, s. 210-216
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Tidskriftsartikel (refereegranskat)abstract
- The interaction of thrombocyte vesicles with the surface of metal electrodes, i.e., mercury, gold and gold electrodes modified with self assembled monolayers (SAM), was studied with the help of chronoamperometry, atomic force microscopy, and quartz crystal microbalance measurements. The experimental results show that the interaction of the thrombocyte vesicles with the surface of the electrodes depends on the hydrophobicity of the latter: whereas on very hydrophobic surfaces (mercury and gold functionalized with SAM) the thrombocyte vesicles disintegrate and form a monolayer of lipids. on the less hydrophobic gold surface a bilayer is formed. The chronoamperometric measurements indicate the possibility of future applications to probe membrane properties of thrombocytes. (C) 2008 Elsevier B.V. All rights reserved.
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| 7. |
- Pelletier, N., et al.
(författare)
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Not all salmon are created equal : Life cycle assessment (LCA) of global salmon farming systems
- 2009
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 43:23, s. 8730-8736
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Tidskriftsartikel (refereegranskat)abstract
- We present a global-scale life cycle assessment of a major food commodity, farmed salmon. Specifically, we report the cumulative energy use, biotic resource use, and greenhouse gas, acidifying, and eutrophying emissions associated with producing farmed salmon in Norway, the UK, British Columbia (Canada), and Chile, as well as a production-weighted global average. We found marked differences in the nature and quantity of material/energy resource use and associated emissions per unit production across regions. This suggests significant scope for improved environmental performance in the industry as a whole. We identify key leverage points for improving performance, most notably the critical importance of least-environmental cost feed sourcing patterns and continued improvements in feed conversion efficiency. Overall, impacts were lowest for Norwegian production in most impact categories, and highest for UK farmed salmon. Our results are of direct relevance to industry, policy makers, eco-labeling programs, and consumers seeking to further sustainability objectives in salmon aquaculture. © 2009 American Chemical Society.
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